Determinants of piglet gut microbiome colonization: roles of genetics, nutrition, therapeutics, and the impact of enteric pathogens like PEDV
The gut microbiota of piglets is crucial for intestinal health and immune function, yet highly susceptible to various factors. Multiple factors such as Genetic and Sow Factors, feeding environment, diet and pathogen combine to shape the gut microbiota of piglets. PEDV, a highly pathogenic and transm...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1626239/full |
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| author | Yanzhuo Lv Yanzhuo Lv Yu Zhou Yu Zhou Hongde Lu Hongde Lu Hong Dong Hong Dong Zhiyuan He |
| author_facet | Yanzhuo Lv Yanzhuo Lv Yu Zhou Yu Zhou Hongde Lu Hongde Lu Hong Dong Hong Dong Zhiyuan He |
| author_sort | Yanzhuo Lv |
| collection | DOAJ |
| description | The gut microbiota of piglets is crucial for intestinal health and immune function, yet highly susceptible to various factors. Multiple factors such as Genetic and Sow Factors, feeding environment, diet and pathogen combine to shape the gut microbiota of piglets. PEDV, a highly pathogenic and transmissible virus, disrupts the gut microbiota by damaging the intestinal epithelial barrier, leading to microbial imbalance, weakened gut immunity, and severe diarrhea. In this review, we systematically investigated the factors affecting microbial colonization in the gastrointestinal tract of piglets and the effects of PEDV infection on intestinal microecology, intestinal epithelial barrier and mucosal immunity. Meanwhile, the unique potential of Chinese herbal medicines compound represented by Qiwen Huangbai San in repairing the barrier, remodeling the flora and enhancing the immunity was discussed in depth. Through the above multidimensional perspectives, this review aims to provide a scientific basis and an effective preventive strategy for the construction of a comprehensive prevention and control program centered on Chinese herbs to alleviate the intestinal damage caused by PEDV in piglets. |
| format | Article |
| id | doaj-art-d4e5d0cc8ffb4ebfa5f10f57fe780de9 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-d4e5d0cc8ffb4ebfa5f10f57fe780de92025-08-25T05:26:25ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-08-011510.3389/fcimb.2025.16262391626239Determinants of piglet gut microbiome colonization: roles of genetics, nutrition, therapeutics, and the impact of enteric pathogens like PEDVYanzhuo Lv0Yanzhuo Lv1Yu Zhou2Yu Zhou3Hongde Lu4Hongde Lu5Hong Dong6Hong Dong7Zhiyuan He8Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, ChinaBeijing Engineering Research Center of Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, ChinaBeijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, ChinaBeijing Engineering Research Center of Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, ChinaBeijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, ChinaBeijing Engineering Research Center of Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, ChinaBeijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, ChinaBeijing Engineering Research Center of Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, ChinaBeijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, ChinaThe gut microbiota of piglets is crucial for intestinal health and immune function, yet highly susceptible to various factors. Multiple factors such as Genetic and Sow Factors, feeding environment, diet and pathogen combine to shape the gut microbiota of piglets. PEDV, a highly pathogenic and transmissible virus, disrupts the gut microbiota by damaging the intestinal epithelial barrier, leading to microbial imbalance, weakened gut immunity, and severe diarrhea. In this review, we systematically investigated the factors affecting microbial colonization in the gastrointestinal tract of piglets and the effects of PEDV infection on intestinal microecology, intestinal epithelial barrier and mucosal immunity. Meanwhile, the unique potential of Chinese herbal medicines compound represented by Qiwen Huangbai San in repairing the barrier, remodeling the flora and enhancing the immunity was discussed in depth. Through the above multidimensional perspectives, this review aims to provide a scientific basis and an effective preventive strategy for the construction of a comprehensive prevention and control program centered on Chinese herbs to alleviate the intestinal damage caused by PEDV in piglets.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1626239/fullporcine epidemic diarrhea virus (PEDV)intestinal microbiota of pigletsherbal preparationstraditional Chinese medicine (TCM)gut microbiota |
| spellingShingle | Yanzhuo Lv Yanzhuo Lv Yu Zhou Yu Zhou Hongde Lu Hongde Lu Hong Dong Hong Dong Zhiyuan He Determinants of piglet gut microbiome colonization: roles of genetics, nutrition, therapeutics, and the impact of enteric pathogens like PEDV Frontiers in Cellular and Infection Microbiology porcine epidemic diarrhea virus (PEDV) intestinal microbiota of piglets herbal preparations traditional Chinese medicine (TCM) gut microbiota |
| title | Determinants of piglet gut microbiome colonization: roles of genetics, nutrition, therapeutics, and the impact of enteric pathogens like PEDV |
| title_full | Determinants of piglet gut microbiome colonization: roles of genetics, nutrition, therapeutics, and the impact of enteric pathogens like PEDV |
| title_fullStr | Determinants of piglet gut microbiome colonization: roles of genetics, nutrition, therapeutics, and the impact of enteric pathogens like PEDV |
| title_full_unstemmed | Determinants of piglet gut microbiome colonization: roles of genetics, nutrition, therapeutics, and the impact of enteric pathogens like PEDV |
| title_short | Determinants of piglet gut microbiome colonization: roles of genetics, nutrition, therapeutics, and the impact of enteric pathogens like PEDV |
| title_sort | determinants of piglet gut microbiome colonization roles of genetics nutrition therapeutics and the impact of enteric pathogens like pedv |
| topic | porcine epidemic diarrhea virus (PEDV) intestinal microbiota of piglets herbal preparations traditional Chinese medicine (TCM) gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1626239/full |
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