Structural basis of broad protection against influenza virus by human antibodies targeting the neuraminidase active site via a recurring motif in CDR H3

Structural basis of broad protection against influenza virus by human antibodies targeting the neuraminidase active site via a recurring motif in CDR H3

Abstract Influenza viruses evolve rapidly, driving seasonal epidemics and posing global pandemic threats. While neuraminidase (NA) has emerged as a vaccine target, shared molecular features of NA antibody responses are still not well understood. Here, we describe cryo-electron microscopy structures...

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Main Authors: Gyunghee Jo, Seiya Yamayoshi, Krystal M. Ma, Olivia Swanson, Jonathan L. Torres, James A. Ferguson, Monica L. Fernández-Quintero, Jiachen Huang, Jeffrey Copps, Alesandra J. Rodriguez, Jon M. Steichen, Yoshihiro Kawaoka, Julianna Han, Andrew B. Ward
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62174-2
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https://doi.org/10.1038/s41467-025-62174-2

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