Value of aspartate aminotransferase/alanine aminotransferase Ratio in predicting coronary thrombus burden in ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention
Background and aim The liver is extremely responsive to circulatory hemodynamics as a result of its intricate network of blood arteries. Elevated blood transaminase levels are frequently detected in individuals with myocardial infarction, this study is to determine the predictive value of the aspart...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Al-Azhar Assiut Medical Journal |
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| Online Access: | https://journals.lww.com/10.4103/azmj.azmj_27_24 |
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| author | Mohamed Aboelhassan Mohamed A.-K.F. Abdelmegid Sawsan M. Moeen Salma M. Hassan Ishraq H. AbdEl-Hameed Khaled M.A. Shehata |
| author_facet | Mohamed Aboelhassan Mohamed A.-K.F. Abdelmegid Sawsan M. Moeen Salma M. Hassan Ishraq H. AbdEl-Hameed Khaled M.A. Shehata |
| author_sort | Mohamed Aboelhassan |
| collection | DOAJ |
| description | Background and aim
The liver is extremely responsive to circulatory hemodynamics as a result of its intricate network of blood arteries. Elevated blood transaminase levels are frequently detected in individuals with myocardial infarction, this study is to determine the predictive value of the aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio and different clinical parameters in assessing the severity of coronary thrombus burden in patients with ST-elevation myocardial infarction (STEMI) undergoing primary PCI.
Patients and methods
This is a prospective cohort study conducted on 115 patients with acute STEMI (ST segment myocardial infarction) who underwent primary PCI. AST/ALT ratio was calculated for each patient. Evaluation of the extent of thrombus burden using the thrombolysis in myocardial infarction (TIMI) scoring system.
Results
56 patients had AST/ALT ratio greater than 2, while 59 patients had AST/ALT ratio less than 2. STEMI patients with AST/ALT ratio greater than 2 had a significantly higher prevalence of total vessel occlusion (TIMI thrombus grade 5), and there is a significant association between high AST/ALT ratio and TIMI thrombus grade 5 on both univariate and multivariate analysis. However, there is no statistically significant difference between both groups as regarding the coronary artery complexity as assessed by SYNTAX and Genseni scores.
Conclusion
Patients with AST/ALT ratio greater than 2 are strongly associated with high thrombus burden (thrombus burden of 5) on TIMI thrombus grade before primary PCI. |
| format | Article |
| id | doaj-art-d4c94f4b7c944af1a34c57510f4b9eb9 |
| institution | Kabale University |
| issn | 1687-1693 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Al-Azhar Assiut Medical Journal |
| spelling | doaj-art-d4c94f4b7c944af1a34c57510f4b9eb92025-01-17T15:45:13ZengWolters Kluwer Medknow PublicationsAl-Azhar Assiut Medical Journal1687-16932024-01-01221384310.4103/azmj.azmj_27_24Value of aspartate aminotransferase/alanine aminotransferase Ratio in predicting coronary thrombus burden in ST elevation myocardial infarction patients undergoing primary percutaneous coronary interventionMohamed AboelhassanMohamed A.-K.F. AbdelmegidSawsan M. MoeenSalma M. HassanIshraq H. AbdEl-HameedKhaled M.A. ShehataBackground and aim The liver is extremely responsive to circulatory hemodynamics as a result of its intricate network of blood arteries. Elevated blood transaminase levels are frequently detected in individuals with myocardial infarction, this study is to determine the predictive value of the aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio and different clinical parameters in assessing the severity of coronary thrombus burden in patients with ST-elevation myocardial infarction (STEMI) undergoing primary PCI. Patients and methods This is a prospective cohort study conducted on 115 patients with acute STEMI (ST segment myocardial infarction) who underwent primary PCI. AST/ALT ratio was calculated for each patient. Evaluation of the extent of thrombus burden using the thrombolysis in myocardial infarction (TIMI) scoring system. Results 56 patients had AST/ALT ratio greater than 2, while 59 patients had AST/ALT ratio less than 2. STEMI patients with AST/ALT ratio greater than 2 had a significantly higher prevalence of total vessel occlusion (TIMI thrombus grade 5), and there is a significant association between high AST/ALT ratio and TIMI thrombus grade 5 on both univariate and multivariate analysis. However, there is no statistically significant difference between both groups as regarding the coronary artery complexity as assessed by SYNTAX and Genseni scores. Conclusion Patients with AST/ALT ratio greater than 2 are strongly associated with high thrombus burden (thrombus burden of 5) on TIMI thrombus grade before primary PCI.https://journals.lww.com/10.4103/azmj.azmj_27_24aspartate aminotransferase/alanine aminotransferase>2primary pcist-elevation myocardial infarctionthrombolysis in myocardial infarction thrombus grade |
| spellingShingle | Mohamed Aboelhassan Mohamed A.-K.F. Abdelmegid Sawsan M. Moeen Salma M. Hassan Ishraq H. AbdEl-Hameed Khaled M.A. Shehata Value of aspartate aminotransferase/alanine aminotransferase Ratio in predicting coronary thrombus burden in ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention Al-Azhar Assiut Medical Journal aspartate aminotransferase/alanine aminotransferase>2 primary pci st-elevation myocardial infarction thrombolysis in myocardial infarction thrombus grade |
| title | Value of aspartate aminotransferase/alanine aminotransferase Ratio in predicting coronary thrombus burden in ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention |
| title_full | Value of aspartate aminotransferase/alanine aminotransferase Ratio in predicting coronary thrombus burden in ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention |
| title_fullStr | Value of aspartate aminotransferase/alanine aminotransferase Ratio in predicting coronary thrombus burden in ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention |
| title_full_unstemmed | Value of aspartate aminotransferase/alanine aminotransferase Ratio in predicting coronary thrombus burden in ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention |
| title_short | Value of aspartate aminotransferase/alanine aminotransferase Ratio in predicting coronary thrombus burden in ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention |
| title_sort | value of aspartate aminotransferase alanine aminotransferase ratio in predicting coronary thrombus burden in st elevation myocardial infarction patients undergoing primary percutaneous coronary intervention |
| topic | aspartate aminotransferase/alanine aminotransferase>2 primary pci st-elevation myocardial infarction thrombolysis in myocardial infarction thrombus grade |
| url | https://journals.lww.com/10.4103/azmj.azmj_27_24 |
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