Risk factors affecting polygenic score performance across diverse cohorts

Risk factors affecting polygenic score performance across diverse cohorts

Apart from ancestry, personal or environmental covariates may contribute to differences in polygenic score (PGS) performance. We analyzed the effects of covariate stratification and interaction on body mass index (BMI) PGS (PGSBMI) across four cohorts of European (N = 491,111) and African (N = 21,61...

Full description

Saved in:

Bibliographic Details
Main Authors:	Daniel Hui, Scott Dudek, Krzysztof Kiryluk, Theresa L Walunas, Iftikhar J Kullo, Wei-Qi Wei, Hemant Tiwari, Josh F Peterson, Wendy K Chung, Brittney H Davis, Atlas Khan, Leah C Kottyan, Nita A Limdi, Qiping Feng, Megan J Puckelwartz, Chunhua Weng, Johanna L Smith, Elizabeth W Karlson, Regeneron Genetics Center, Penn Medicine BioBank, Gail P Jarvik, Marylyn D Ritchie
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-01-01
Series:	eLife
Subjects:	polygenic scores body mass index gene–environment GWAS
Online Access:	https://elifesciences.org/articles/88149
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Polygenic diseases
by: Sergey Dolomatov, et al.
Published: (2025-01-01)

Polygenic prediction of human longevity on the supposition of pervasive pleiotropy
by: M. Reza Jabalameli, et al.
Published: (2024-08-01)

Association of polygenic scores for autism with volumetric MRI phenotypes in cerebellum and brainstem in adults
by: Salahuddin Mohammad, et al.
Published: (2024-08-01)

Polygenic Genetic Analysis of Principal Genes for Yield Traits in Land Cotton
by: Xiaoman Ma, et al.
Published: (2024-11-01)

Development and evaluation of patient-centred polygenic risk score reports for glaucoma screening
by: Georgina L Hollitt, et al.
Published: (2025-01-01)

Alzheimer's polygenic hazard score in SuperAgers: SuperGenes or SuperResilience?
by: Barbara E. Spencer, et al.
Published: (2022-01-01)

Benchmarking Alzheimer’s disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies
by: Eftychia Bellou, et al.
Published: (2025-01-01)

Enhancing the utility of polygenic scores in Alzheimer’s disease through systematic curation and annotation
by: Savannah Mwesigwa, et al.
Published: (2025-02-01)

Relationships between the Planetary Health Diet Index, its food groups, and polygenic risk of obesity in the CARTaGENE cohort
by: Guiomar Masip, et al.
Published: (2024-12-01)

Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction
by: Kristia Yiangou, et al.
Published: (2024-12-01)

Effects of the Interaction Between Oxidative Balance Score and Polygenic Risk Scores on Incidence of Metabolic Syndrome in Middle-Aged Korean Adults
by: Minyeong Kim, et al.
Published: (2024-12-01)

Investigating the effect of polygenic background on epilepsy phenotype in ‘monogenic’ familiesResearch in context
by: Karen L. Oliver, et al.
Published: (2024-11-01)

Interplay between lifestyle factors and polygenic risk for incident coronary heart disease in a large multiethnic cohort
by: Carlos Iribarren, et al.
Published: (2024-12-01)

Socioeconomic disadvantage and polygenic risk of overweight in early and mid-life: a longitudinal population cohort study spanning 12 yearsResearch in context
by: Jessica A. Kerr, et al.
Published: (2024-12-01)

Risk of adverse cardiovascular events based on common genetic variants in 8-year follow-up of the LIPIDOGEN2015 population using the polygenic risk score (PRS): study design and methodology
by: Maciej Banach, et al.
Published: (2024-08-01)

Genetic Analysis of Flowering Time in Pansies Using Mixed Major Gene Plus Polygene Inheritance Model
by: Jiayi Liu, et al.
Published: (2024-12-01)

Patient Perspectives on Personalized Risk Communication Using Polygenic Risk Scores to Inform Colorectal Cancer Screening Decisions
by: Shauna R. Goldberg, MPH, et al.
Published: (2025-02-01)

The clinical value and most informative threshold of polygenic risk score in the Quebec City Case-Control Asthma Cohort
by: Martin Pariès, et al.
Published: (2025-01-01)

Polygenic Risk Score Improves Melanoma Risk Assessment in a Patient Cohort from the Veneto Region of Italy
by: Stefania Pellegrini, et al.
Published: (2024-11-01)

Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sample
by: Kit K. Elam, et al.
Published: (2024-12-01)

Blood Lipid Polygenic Risk Score Development and Application for Atherosclerosis Ultrasound Parameters
by: Marija Zaicenoka, et al.
Published: (2024-12-01)

Genetic risk stratification and risk factors of early menopause in women: a multi-center study utilizing polygenic risk scores
by: Wei Zhong, et al.
Published: (2024-12-01)

Associations between a polygenic risk score and the risk of gestational diabetes mellitus in a Chinese population: a case-control study
by: Ying Li, et al.
Published: (2023-12-01)

Exploring the Genetic Relationship Between Type 2 Diabetes and Cardiovascular Disease: A Large-Scale Genetic Association and Polygenic Risk Score Study
by: Ziwei Yao, et al.
Published: (2024-11-01)

Validation of GenProb‐T1D and its clinical utility for differentiating types of diabetes in a biobank from a US healthcare system
by: Liana K. Billings, et al.
Published: (2025-01-01)

Triglyceride-glucose index and its additive interaction with ABCG2/SLC2A9 polygenic risk score on hyperuricemia in middle age and older adults: findings from the DLCC and BHMC study
by: Huijing He, et al.
Published: (2024-12-01)

Polygenous and polychronous gold mineralization of the Middle Urals: Staging of appearance of the gold-bearing hydrothermal-metasomatic processes
by: Ivanov A. I., et al.
Published: (2024-12-01)

Archaic introgression contributed to shape the adaptive modulation of angiogenesis and cardiovascular traits in human high-altitude populations from the Himalayas
by: Giulia Ferraretti, et al.
Published: (2024-11-01)

Applications of Molecular Markers in Fruit Crops: A Review
by: Manika Goswami, et al.
Published: (2022-04-01)

Nature or nurture: genetic and environmental predictors of adiposity gain in adultsResearch in context
by: Laia Peruchet-Noray, et al.
Published: (2025-01-01)

Cancer, genetic susceptibility and risk of coronary artery disease: A prospective study
by: Yidan Wang, et al.
Published: (2025-03-01)

Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population
by: Yinghao Yao, et al.
Published: (2025-01-01)

Linking obesity-associated genotype to child language development: the role of early-life neurology-related proteomics and brain myelinationResearch in context
by: Jian Huang, et al.
Published: (2025-03-01)

Rs867228 in FPR1 accelerates the manifestation of luminal B breast cancer
by: Vincent Carbonnier, et al.
Published: (2023-12-01)

Commentary: Relationships between screen time and childhood attention deficit hyperactivity disorder: a Mendelian randomization study
by: Nagahide Takahashi, et al.
Published: (2024-12-01)

The Genetics of Partnership Dissolution
by: Ruth Eva Jørgensen, et al.
Published: (2025-01-01)

The role of candidate genetic polymorphisms in covid-19 susceptibility and outcomes
by: Anthony Yazbeck, et al.
Published: (2025-02-01)

Ultra-processed food intake, genetic polymorphisms, and the risk of dyslipidemia in the adult Korean population
by: Minsu Cho, et al.

Genetic Determinants of Left Atrial Function Are Associated With Stroke
by: Oliver B. Vad, et al.
Published: (2024-12-01)

Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexusResearch in context
by: Xiaonan Guo, et al.
Published: (2025-01-01)