Use of valproic acid in long stay units of psychiatry
Objective: Valproic acid is often used in psychiatry to treat schizophrenia and other conditions outside of indication (“off-label”). However, its effectiveness has not been sufficiently demonstrated and its use is not exempt of adverse effects. This study’s main objective is to determine the freque...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Farmacia Hospitalaria |
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| Online Access: | http://www.aulamedica.es/fh/pdf/8460.pdf |
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| author | Mª Teresa Martínez-Lazcano Sara Esplá-González Paola Herraiz-Robles Pilar Hernández-Pérez Raquel Chillerón-Cuenca Emilio Pol-Yanguas |
| author_facet | Mª Teresa Martínez-Lazcano Sara Esplá-González Paola Herraiz-Robles Pilar Hernández-Pérez Raquel Chillerón-Cuenca Emilio Pol-Yanguas |
| author_sort | Mª Teresa Martínez-Lazcano |
| collection | DOAJ |
| description | Objective: Valproic acid is often used in psychiatry to treat schizophrenia and other conditions outside of indication (“off-label”). However, its effectiveness has not been sufficiently demonstrated and its use is not exempt of adverse effects. This study’s main objective is to determine the frequency of use of valproic acid in approved indications and the “off-label” use in psychiatric patients. Methods: A cross-sectional study on July 7, 2014 with a sample of 167 patients residents in a psychiatric center was designed. Demographics, valproic acid treatment, posology and associated drug treatment, monitoring safety parameters, interactions and valproic acid concentrations. Results: Valproic acid is prescribed in 1 of 3 patients of the center. It was used in the approved indications in 8 (15%) of the 53 patients analyzed: 5 (9%) of them with bipolar disorder and 3 (6%) diagnosed with epilepsy. Other 5 patients (9%) were included in the extended schizoaffective disorder indication. 76% (40) of the evaluated patients were prescribed valproic acid off-label. The mean dose of valproic acid was 1.26 Defined Daily Dose / patient / day. An average of 6 drugs associated with valproic acid was found. 18% of patients had thrombocytopenia. Conclusions: Valproic acid is often used off-label in psychiatric patients. It should be assessed the benefit-risk in this population |
| format | Article |
| id | doaj-art-d49f98b903294f58bce73b8e5c49c57a |
| institution | Kabale University |
| issn | 1130-6343 2171-8695 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Farmacia Hospitalaria |
| spelling | doaj-art-d49f98b903294f58bce73b8e5c49c57a2025-01-02T16:24:36ZengElsevierFarmacia Hospitalaria1130-63432171-86952015-01-013939210110.7399/fh.2015.39.2.8460Use of valproic acid in long stay units of psychiatryMª Teresa Martínez-Lazcano0Sara Esplá-González1Paola Herraiz-Robles2Pilar Hernández-Pérez3Raquel Chillerón-Cuenca4Emilio Pol-Yanguas5Hospital Universitario Sant Joan D’AlacantHospital Universitario Sant Joan D’AlacantHospital Universitario Sant Joan D’AlacantLicenciada en FarmaciaLicenciada en FarmaciaCentro Dr. Esquerdo Sant Joan D’Alacant. EspañaObjective: Valproic acid is often used in psychiatry to treat schizophrenia and other conditions outside of indication (“off-label”). However, its effectiveness has not been sufficiently demonstrated and its use is not exempt of adverse effects. This study’s main objective is to determine the frequency of use of valproic acid in approved indications and the “off-label” use in psychiatric patients. Methods: A cross-sectional study on July 7, 2014 with a sample of 167 patients residents in a psychiatric center was designed. Demographics, valproic acid treatment, posology and associated drug treatment, monitoring safety parameters, interactions and valproic acid concentrations. Results: Valproic acid is prescribed in 1 of 3 patients of the center. It was used in the approved indications in 8 (15%) of the 53 patients analyzed: 5 (9%) of them with bipolar disorder and 3 (6%) diagnosed with epilepsy. Other 5 patients (9%) were included in the extended schizoaffective disorder indication. 76% (40) of the evaluated patients were prescribed valproic acid off-label. The mean dose of valproic acid was 1.26 Defined Daily Dose / patient / day. An average of 6 drugs associated with valproic acid was found. 18% of patients had thrombocytopenia. Conclusions: Valproic acid is often used off-label in psychiatric patients. It should be assessed the benefit-risk in this populationhttp://www.aulamedica.es/fh/pdf/8460.pdfValproic acidOff-label; Schizophrenia; Psychiatry; Antipsychotics |
| spellingShingle | Mª Teresa Martínez-Lazcano Sara Esplá-González Paola Herraiz-Robles Pilar Hernández-Pérez Raquel Chillerón-Cuenca Emilio Pol-Yanguas Use of valproic acid in long stay units of psychiatry Farmacia Hospitalaria Valproic acid Off-label ; Schizophrenia ; Psychiatry ; Antipsychotics |
| title | Use of valproic acid in long stay units of psychiatry |
| title_full | Use of valproic acid in long stay units of psychiatry |
| title_fullStr | Use of valproic acid in long stay units of psychiatry |
| title_full_unstemmed | Use of valproic acid in long stay units of psychiatry |
| title_short | Use of valproic acid in long stay units of psychiatry |
| title_sort | use of valproic acid in long stay units of psychiatry |
| topic | Valproic acid Off-label ; Schizophrenia ; Psychiatry ; Antipsychotics |
| url | http://www.aulamedica.es/fh/pdf/8460.pdf |
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