GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE
Advances in molecular biology and genetic testing have greatly improved our understanding of the genetic basis of hematologic malignancies and have enabled the identification of new cancer predisposition syndromes. The recognition of a germline mutation in a patient affected by a hematologic malign...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2023-04-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/5326 |
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| _version_ | 1841563028306264064 |
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| author | Francesco Fabozzi Angela Mastronuzzi |
| author_facet | Francesco Fabozzi Angela Mastronuzzi |
| author_sort | Francesco Fabozzi |
| collection | DOAJ |
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Advances in molecular biology and genetic testing have greatly improved our understanding of the genetic basis of hematologic malignancies and have enabled the identification of new cancer predisposition syndromes. The recognition of a germline mutation in a patient affected by a hematologic malignancy allows for a tailored treatment approach in order to minimize toxicities, and informs the donor selection for hematopoietic stem cell transplantation as well as the comorbidities evaluation and surveillance strategies.
This review provides an overview of germline mutations that predispose to hematologic malignancies, focusing on those most common during childhood and adolescence, based on the new International Consensus Classification of Myeloid and Lymphoid Neoplasms.
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| format | Article |
| id | doaj-art-d490e3178a274704aef7df54594080b3 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-d490e3178a274704aef7df54594080b32025-01-03T00:30:36ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062023-04-0115110.4084/MJHID.2023.032GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCEFrancesco Fabozzi0Angela Mastronuzzi1a:1:{s:5:"en_US";s:127:"Department of Pediatric Hematology/Oncology and Cellular and Gene Therapy, Bambino Gesù Children's Hospital IRCCS, Rome, Italy";}Department of Pediatric Hematology/Oncology and Cellular and Gene Therapy, Bambino Gesù Children's Hospital IRCCS, Rome, Italy Advances in molecular biology and genetic testing have greatly improved our understanding of the genetic basis of hematologic malignancies and have enabled the identification of new cancer predisposition syndromes. The recognition of a germline mutation in a patient affected by a hematologic malignancy allows for a tailored treatment approach in order to minimize toxicities, and informs the donor selection for hematopoietic stem cell transplantation as well as the comorbidities evaluation and surveillance strategies. This review provides an overview of germline mutations that predispose to hematologic malignancies, focusing on those most common during childhood and adolescence, based on the new International Consensus Classification of Myeloid and Lymphoid Neoplasms. http://www.mjhid.org/index.php/mjhid/article/view/5326 |
| spellingShingle | Francesco Fabozzi Angela Mastronuzzi GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE Mediterranean Journal of Hematology and Infectious Diseases |
| title | GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE |
| title_full | GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE |
| title_fullStr | GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE |
| title_full_unstemmed | GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE |
| title_short | GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE |
| title_sort | genetic predisposition to hematologic malignancies in childhood and adolescence |
| url | http://www.mjhid.org/index.php/mjhid/article/view/5326 |
| work_keys_str_mv | AT francescofabozzi geneticpredispositiontohematologicmalignanciesinchildhoodandadolescence AT angelamastronuzzi geneticpredispositiontohematologicmalignanciesinchildhoodandadolescence |