Diverse phenotype of Ménière's disease associated with family history, thyroid disorder, migraine and associated disorders
Objective: To better understand the clinical phenotype of Ménière's disease (MD), we examined family history, thyroid disorder, migraine, and associated disorders in complaints of people living with MD. Method: We designed the study as a retrospective and examined data gathered from 912 partici...
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Elsevier
2024-10-01
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| Series: | Journal of Otology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1672293024000345 |
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| author | Ilmari Pyykkö Vinay Jing Zou Artur Vetkas Vinaya Manchaiah |
| author_facet | Ilmari Pyykkö Vinay Jing Zou Artur Vetkas Vinaya Manchaiah |
| author_sort | Ilmari Pyykkö |
| collection | DOAJ |
| description | Objective: To better understand the clinical phenotype of Ménière's disease (MD), we examined family history, thyroid disorder, migraine, and associated disorders in complaints of people living with MD. Method: We designed the study as a retrospective and examined data gathered from 912 participants with MD. Their data were originally collected by the Finnish Ménière Federation (FMF). The survey data included individual case histories for environmental factors, comorbidities, disease-specific complaints, impact-related questions, cognitive complaints, health-related quality of life (HRQoL), and sense of coherence (SOC). Results: We observed significant differences between those with and without sporadic occurrence, family history, thyroid disorder, and migraine-associated complaints. Family history explained 20% of variability in patient complaints. Patients with a family history of MD whose disease started at younger age experienced balance problems, more severe vertigo spells, more severe vestibular drop attacks (VDA), and less nausea, although they had good SOC. Thyroid disorder explained 14% of variability in patient complaints. MD patients with a thyroid disorder comorbidity suffered more often from constant dizziness, balance problems, greater impact of hearing problems, cognitive complaints, and poor HRQoL. Migraine explained 12% of variability in patients’ complaints and was associated with poor SOC and cognitive balance problems. MD patients with both thyroid disorder and migraine used antidepressants more often than other groups. Logistic regression analysis showed comorbidities of ischemic brain disorder (among 7.1%), kidney insufficiency (among 1.2%), and diabetes (among 7.3%) had statistically significant but restricted association with balance and gait problems, VDA, and reduced HRQoL. Conclusions: Family history of MD and thyroid disorder or migraine comorbidities in MD influence the complaint pattern and partially explain complex symptom profiles, including symptoms of cognitive problems. Confounders play a minimal role in complaint profile and impact of MD whereas comorbidities influence the complaint structure and partly explain the complex symptom profile in MD. |
| format | Article |
| id | doaj-art-d490de2c108b4700b5dcf3efde1e589c |
| institution | Kabale University |
| issn | 1672-2930 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Otology |
| spelling | doaj-art-d490de2c108b4700b5dcf3efde1e589c2024-12-11T05:55:51ZengElsevierJournal of Otology1672-29302024-10-01194185192Diverse phenotype of Ménière's disease associated with family history, thyroid disorder, migraine and associated disordersIlmari Pyykkö0 Vinay1Jing Zou2Artur Vetkas3Vinaya Manchaiah4Hearing and Balance Research Unit, Field of Otolaryngology, School of Medicine, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandAudiology Group, Department of Neuromedicine and Movement Sciences, Norwegian University of Science and Technology, Trondheim, Norway; Department of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO, USA; Corresponding author. University of Colorado School of Medicine, Aurora, CO, 80045, USA.Hearing and Balance Research Unit, Field of Otolaryngology, School of Medicine, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Otolaryngology-Head and Neck Surgery, Center for Otolaryngology-Head & Neck Surgery of the Chinese PLA, Changhai Hospital, Second Military Medical University, Shanghai, ChinaNeurology Clinic, Department of Neurosurgery, Tartu University Hospital, Tartu, EstoniaDepartment of Otolaryngology-Head and Neck Surgery, University of Colorado School of Medicine, Aurora, CO, USA; UCHealth Hearing and Balance, University of Colorado Hospital, Aurora, CO, USA; Virtual Hearing Lab, Collaborative Initiative Between University of Colorado School of Medicine and University of Pretoria, Aurora, CO, USA; Department of Speech-Language Pathology and Audiology, University of Pretoria, Pretoria, South Africa; Department of Speech and Hearing, School of Allied Health Sciences, Manipal University, Manipal, Karnataka, IndiaObjective: To better understand the clinical phenotype of Ménière's disease (MD), we examined family history, thyroid disorder, migraine, and associated disorders in complaints of people living with MD. Method: We designed the study as a retrospective and examined data gathered from 912 participants with MD. Their data were originally collected by the Finnish Ménière Federation (FMF). The survey data included individual case histories for environmental factors, comorbidities, disease-specific complaints, impact-related questions, cognitive complaints, health-related quality of life (HRQoL), and sense of coherence (SOC). Results: We observed significant differences between those with and without sporadic occurrence, family history, thyroid disorder, and migraine-associated complaints. Family history explained 20% of variability in patient complaints. Patients with a family history of MD whose disease started at younger age experienced balance problems, more severe vertigo spells, more severe vestibular drop attacks (VDA), and less nausea, although they had good SOC. Thyroid disorder explained 14% of variability in patient complaints. MD patients with a thyroid disorder comorbidity suffered more often from constant dizziness, balance problems, greater impact of hearing problems, cognitive complaints, and poor HRQoL. Migraine explained 12% of variability in patients’ complaints and was associated with poor SOC and cognitive balance problems. MD patients with both thyroid disorder and migraine used antidepressants more often than other groups. Logistic regression analysis showed comorbidities of ischemic brain disorder (among 7.1%), kidney insufficiency (among 1.2%), and diabetes (among 7.3%) had statistically significant but restricted association with balance and gait problems, VDA, and reduced HRQoL. Conclusions: Family history of MD and thyroid disorder or migraine comorbidities in MD influence the complaint pattern and partially explain complex symptom profiles, including symptoms of cognitive problems. Confounders play a minimal role in complaint profile and impact of MD whereas comorbidities influence the complaint structure and partly explain the complex symptom profile in MD.http://www.sciencedirect.com/science/article/pii/S1672293024000345Ménière's diseaseMigraineThyroidFamily historyHereditary |
| spellingShingle | Ilmari Pyykkö Vinay Jing Zou Artur Vetkas Vinaya Manchaiah Diverse phenotype of Ménière's disease associated with family history, thyroid disorder, migraine and associated disorders Journal of Otology Ménière's disease Migraine Thyroid Family history Hereditary |
| title | Diverse phenotype of Ménière's disease associated with family history, thyroid disorder, migraine and associated disorders |
| title_full | Diverse phenotype of Ménière's disease associated with family history, thyroid disorder, migraine and associated disorders |
| title_fullStr | Diverse phenotype of Ménière's disease associated with family history, thyroid disorder, migraine and associated disorders |
| title_full_unstemmed | Diverse phenotype of Ménière's disease associated with family history, thyroid disorder, migraine and associated disorders |
| title_short | Diverse phenotype of Ménière's disease associated with family history, thyroid disorder, migraine and associated disorders |
| title_sort | diverse phenotype of meniere s disease associated with family history thyroid disorder migraine and associated disorders |
| topic | Ménière's disease Migraine Thyroid Family history Hereditary |
| url | http://www.sciencedirect.com/science/article/pii/S1672293024000345 |
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