The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma
BackgroundPTC (papillary thyroid cancer) is a lymphotropic malignancy associated with cervical lymph node metastasis (CLNM, including central and lateral LNM), which compromises the effect of treatment and prognosis of patients. Accurate preoperative identification will provide valuable reference in...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1507953/full |
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| author | Chang Liu Chang Liu Shangjie Yang Shangjie Yang Tian Xue Qian Zhang Qian Zhang Yanjing Zhang Yufang Zhao Guolin Yin Xiaohui Yan Ping Liang Liping Liu |
| author_facet | Chang Liu Chang Liu Shangjie Yang Shangjie Yang Tian Xue Qian Zhang Qian Zhang Yanjing Zhang Yufang Zhao Guolin Yin Xiaohui Yan Ping Liang Liping Liu |
| author_sort | Chang Liu |
| collection | DOAJ |
| description | BackgroundPTC (papillary thyroid cancer) is a lymphotropic malignancy associated with cervical lymph node metastasis (CLNM, including central and lateral LNM), which compromises the effect of treatment and prognosis of patients. Accurate preoperative identification will provide valuable reference information for the formulation of diagnostic and treatment strategies. The aim of this study was to develop and validate a clinical-multimodal ultrasound radiomics model for predicting CLNM of PTC.MethodsOne hundred sixty-four patients with PTC who underwent treatment at our hospital between March 2016 and December 2021 were included in this study. The patients were grouped into a training cohort (n=115) and a validation cohort (n=49). Radiomic features were extracted from the conventional ultrasound (US), contrast-enhanced ultrasound (CEUS) and strain elastography-ultrasound (SE-US) images of patients with PTC. Multivariate logistic regression analysis was used to identify the independent risk factors. FAE software was used for radiomic feature extraction and the construction of different prediction models. The diagnostic performance of each model was evaluated and compared in terms of the area under the curve (AUC), sensitivity, specificity, accuracy, negative predictive value (NPV) and positive predictive value (PPV). RStudio software was used to develop the decision curve and assess the clinical value of the prediction model.ResultsThe clinical-multimodal ultrasound radiomics model developed in this study can successfully detect CLNM in PTC patients. A total of 3720 radiomic features (930 features per modality) were extracted from the ROIs of the multimodal images, and 15 representative features were ultimately screened. The combined model showed the best prediction performance in both the training and validation cohorts, with AUCs of 0.957 (95% CI: 0.918–0.987) and 0.932 (95% CI: 0.822–0.984), respectively. Decision curve analysis revealed that the combined model was superior to the other models.ConclusionThe clinical-multimodal ultrasound radiomics model constructed with multimodal ultrasound radiomic features and clinical risk factors has favorable potential and high diagnostic value for predicting CLNM in PTC patients. |
| format | Article |
| id | doaj-art-d4850332dc974afea8524b4860899155 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-d4850332dc974afea8524b48608991552025-01-17T06:50:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15079531507953The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinomaChang Liu0Chang Liu1Shangjie Yang2Shangjie Yang3Tian Xue4Qian Zhang5Qian Zhang6Yanjing Zhang7Yufang Zhao8Guolin Yin9Xiaohui Yan10Ping Liang11Liping Liu12Department of Interventional Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Ultrasound, Xi'an Central Hospital, Xi'an, ChinaDepartment of Interventional Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Medical Imaging, Shanxi Medical University, Taiyuan, ChinaDepartment of Ultrasound, Shanxi Maternal and Child Health Care Hospital, Shanxi Children's Hospital, Taiyuan, ChinaDepartment of Interventional Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Medical Imaging, Shanxi Medical University, Taiyuan, ChinaDepartment of Interventional Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Interventional Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Interventional Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Interventional Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Interventional Ultrasound, Fifth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, ChinaDepartment of Interventional Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, ChinaBackgroundPTC (papillary thyroid cancer) is a lymphotropic malignancy associated with cervical lymph node metastasis (CLNM, including central and lateral LNM), which compromises the effect of treatment and prognosis of patients. Accurate preoperative identification will provide valuable reference information for the formulation of diagnostic and treatment strategies. The aim of this study was to develop and validate a clinical-multimodal ultrasound radiomics model for predicting CLNM of PTC.MethodsOne hundred sixty-four patients with PTC who underwent treatment at our hospital between March 2016 and December 2021 were included in this study. The patients were grouped into a training cohort (n=115) and a validation cohort (n=49). Radiomic features were extracted from the conventional ultrasound (US), contrast-enhanced ultrasound (CEUS) and strain elastography-ultrasound (SE-US) images of patients with PTC. Multivariate logistic regression analysis was used to identify the independent risk factors. FAE software was used for radiomic feature extraction and the construction of different prediction models. The diagnostic performance of each model was evaluated and compared in terms of the area under the curve (AUC), sensitivity, specificity, accuracy, negative predictive value (NPV) and positive predictive value (PPV). RStudio software was used to develop the decision curve and assess the clinical value of the prediction model.ResultsThe clinical-multimodal ultrasound radiomics model developed in this study can successfully detect CLNM in PTC patients. A total of 3720 radiomic features (930 features per modality) were extracted from the ROIs of the multimodal images, and 15 representative features were ultimately screened. The combined model showed the best prediction performance in both the training and validation cohorts, with AUCs of 0.957 (95% CI: 0.918–0.987) and 0.932 (95% CI: 0.822–0.984), respectively. Decision curve analysis revealed that the combined model was superior to the other models.ConclusionThe clinical-multimodal ultrasound radiomics model constructed with multimodal ultrasound radiomic features and clinical risk factors has favorable potential and high diagnostic value for predicting CLNM in PTC patients.https://www.frontiersin.org/articles/10.3389/fonc.2024.1507953/fullpapillary thyroid carcinoma (PTC)cervical lymph node metastasisradiomicmultimodal ultrasound imagingcontrast-enhanced ultrasound (CEUS)strain elastography-ultrasound (SE-US) |
| spellingShingle | Chang Liu Chang Liu Shangjie Yang Shangjie Yang Tian Xue Qian Zhang Qian Zhang Yanjing Zhang Yufang Zhao Guolin Yin Xiaohui Yan Ping Liang Liping Liu The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma Frontiers in Oncology papillary thyroid carcinoma (PTC) cervical lymph node metastasis radiomic multimodal ultrasound imaging contrast-enhanced ultrasound (CEUS) strain elastography-ultrasound (SE-US) |
| title | The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma |
| title_full | The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma |
| title_fullStr | The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma |
| title_full_unstemmed | The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma |
| title_short | The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma |
| title_sort | application of a clinical multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma |
| topic | papillary thyroid carcinoma (PTC) cervical lymph node metastasis radiomic multimodal ultrasound imaging contrast-enhanced ultrasound (CEUS) strain elastography-ultrasound (SE-US) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1507953/full |
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