Activated hepatic stellate cell-derived small extracellular vesicles facilitate M2 macrophage polarization and hepatoma progression via miR-27a-3p

Activated hepatic stellate cell-derived small extracellular vesicles facilitate M2 macrophage polarization and hepatoma progression via miR-27a-3p

The progression of hepatoma is heavily influenced by the microenvironment. Tumor-associated macrophages (TAMs) are considered to play a critical role in the tumor microenvironment (TME) and increase the aggressiveness of hepatoma. The activation of hepatic stellate cells (HSCs) is involved in hepato...

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Bibliographic Details
Main Authors: Yufeng Sun, Xiaoqian He, Jiayi Han, Wenxuan Yin, Haichen Wang, Jing Li, Weiqi Liu, Xingwang Kuai, Jiaying Lv, Juling Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
hepatic stellate cell
hepatoma
miRNA-27a-3p
tumor-associated macrophages
extracellular vesicles
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1489679/full
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