Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF
Abstract Background Cardiac myosin binding protein C (cMyC) is an emerging new biomarker of myocardial injury rising earlier and cleared faster than cardiac troponins. It has discriminatory power similar to high‐sensitive troponins in diagnosing myocardial infarction in patients presenting with ches...
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Wiley
2025-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.15222 |
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| author | E. Riveland A. Ushakova T. Valborgland T. Karlsen H. Dalen E. Prescott T. Omland A. Linke M. Halle M. Marber Ø. Ellingsen A.I. Larsen the SMARTEX‐HF Study Group |
| author_facet | E. Riveland A. Ushakova T. Valborgland T. Karlsen H. Dalen E. Prescott T. Omland A. Linke M. Halle M. Marber Ø. Ellingsen A.I. Larsen the SMARTEX‐HF Study Group |
| author_sort | E. Riveland |
| collection | DOAJ |
| description | Abstract Background Cardiac myosin binding protein C (cMyC) is an emerging new biomarker of myocardial injury rising earlier and cleared faster than cardiac troponins. It has discriminatory power similar to high‐sensitive troponins in diagnosing myocardial infarction in patients presenting with chest pain. It is also associated with outcome in patients with acute heart failure. It is currently unclear how it relates to cardiac troponins in patients with chronic heart failure undergoing exercise training. Methods and results This is a post hoc analysis of symptomatic heart failure patients in the multicentre randomized SMARTEX trial. Patients were randomized to one of three arms: high‐intensity interval training, moderate continuous training and recommendation of regular exercise serving as control group (CG) for 12 weeks. As the training load in the two intervention arms was similar, these patients were merged and constituted the intervention group (IG). Clinical data and measurements were obtained at baseline and at 12 weeks. In 205 patients, serum was available for cMyC testing and in 196 patients, serum was available for hs‐cTni testing. Due to non‐normal distribution, cMyC and hs‐cTnI measurements were log‐transformed. A Bland–Altman plot was employed to evaluate the agreement of cMyC with hs‐cTnI measurements. Lastly, a linear regression model was applied. No significant differences were observed in the change of cMyC levels between the groups throughout the intervention period (∆ cMyC IG: −0.5 [IQR: −3.4; 2.1] vs. ∆ cMyC CG: −0.7 [IQR: −2.7; 2.6]). The change in log hs‐cTnI was significantly correlated with the change in log cMyC during the 12‐week intervention period, with a Pearson correlation coefficient of R = 0.52 (95% CI 0.37–0.66, P < 0.001). For every 10% increase in cMyC levels, hs‐cTnI levels rose by approximately 5%. Conclusions Changes in levels of the novel biomarker cMyC were significantly associated with hs‐cTnI serum levels in patients with symptomatic chronic HFrEF during a structured 12‐week exercise training programme. This may indicate that cMyC has a role as a future marker of subclinical myocardial damage. |
| format | Article |
| id | doaj-art-d466107d02254d29a8c959891036ece2 |
| institution | DOAJ |
| issn | 2055-5822 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
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| series | ESC Heart Failure |
| spelling | doaj-art-d466107d02254d29a8c959891036ece22025-08-20T03:11:21ZengWileyESC Heart Failure2055-58222025-06-011232382238610.1002/ehf2.15222Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEFE. Riveland0A. Ushakova1T. Valborgland2T. Karlsen3H. Dalen4E. Prescott5T. Omland6A. Linke7M. Halle8M. Marber9Ø. Ellingsen10A.I. Larsen11the SMARTEX‐HF Study GroupDepartment of Cardiology Stavanger University Hospital Stavanger NorwaySection of Biostatistics, Department of Research Stavanger University Hospital Stavanger NorwayDepartment of Clinical Science University of Bergen Bergen NorwayFaculty of Nursing and Health Sciences Nord University, Norway Heart Center Bodø NorwayDepartment of Circulation and Medical Imaging Norwegian University of Science and Technology, Trondheim, Norway; Clinic of Cardiology, St. Olavs University Hospital Trondheim NorwayDepartment of Clinical Medicine Bispebjerg Hospital, University of Copenhagen Copenhagen DenmarkDepartment of Cardiology Akershus University Hospital Lørenskog NorwayTechnische Universität Dresden, Herzzentrum Dresden GermanyDepartment of Prevention and Sports Medicine, Faculty of Medicine University Hospital ‘Klinikum rechts der Isar’, Technical University Munich Munich GermanySchool of Cardiovascular Medicine & Sciences King's College London London UKDepartment of Circulation and Medical Imaging Norwegian University of Science and Technology, Trondheim, Norway; Clinic of Cardiology, St. Olavs University Hospital Trondheim NorwayDepartment of Cardiology Stavanger University Hospital Stavanger NorwayAbstract Background Cardiac myosin binding protein C (cMyC) is an emerging new biomarker of myocardial injury rising earlier and cleared faster than cardiac troponins. It has discriminatory power similar to high‐sensitive troponins in diagnosing myocardial infarction in patients presenting with chest pain. It is also associated with outcome in patients with acute heart failure. It is currently unclear how it relates to cardiac troponins in patients with chronic heart failure undergoing exercise training. Methods and results This is a post hoc analysis of symptomatic heart failure patients in the multicentre randomized SMARTEX trial. Patients were randomized to one of three arms: high‐intensity interval training, moderate continuous training and recommendation of regular exercise serving as control group (CG) for 12 weeks. As the training load in the two intervention arms was similar, these patients were merged and constituted the intervention group (IG). Clinical data and measurements were obtained at baseline and at 12 weeks. In 205 patients, serum was available for cMyC testing and in 196 patients, serum was available for hs‐cTni testing. Due to non‐normal distribution, cMyC and hs‐cTnI measurements were log‐transformed. A Bland–Altman plot was employed to evaluate the agreement of cMyC with hs‐cTnI measurements. Lastly, a linear regression model was applied. No significant differences were observed in the change of cMyC levels between the groups throughout the intervention period (∆ cMyC IG: −0.5 [IQR: −3.4; 2.1] vs. ∆ cMyC CG: −0.7 [IQR: −2.7; 2.6]). The change in log hs‐cTnI was significantly correlated with the change in log cMyC during the 12‐week intervention period, with a Pearson correlation coefficient of R = 0.52 (95% CI 0.37–0.66, P < 0.001). For every 10% increase in cMyC levels, hs‐cTnI levels rose by approximately 5%. Conclusions Changes in levels of the novel biomarker cMyC were significantly associated with hs‐cTnI serum levels in patients with symptomatic chronic HFrEF during a structured 12‐week exercise training programme. This may indicate that cMyC has a role as a future marker of subclinical myocardial damage.https://doi.org/10.1002/ehf2.15222Heart failureBiomarkersCardiac troponincMyC |
| spellingShingle | E. Riveland A. Ushakova T. Valborgland T. Karlsen H. Dalen E. Prescott T. Omland A. Linke M. Halle M. Marber Ø. Ellingsen A.I. Larsen the SMARTEX‐HF Study Group Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF ESC Heart Failure Heart failure Biomarkers Cardiac troponin cMyC |
| title | Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF |
| title_full | Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF |
| title_fullStr | Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF |
| title_full_unstemmed | Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF |
| title_short | Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF |
| title_sort | cardiac myosin binding protein c correlate with cardiac troponin i during an exercise training program in patients with hfref |
| topic | Heart failure Biomarkers Cardiac troponin cMyC |
| url | https://doi.org/10.1002/ehf2.15222 |
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