Characterization of Ultra-Short plasma Cell-Free DNA in maternal blood and its preliminary potential as a screening marker for preeclampsia

Characterization of Ultra-Short plasma Cell-Free DNA in maternal blood and its preliminary potential as a screening marker for preeclampsia

Abstract Background Cell-free DNA (cfDNA) in maternal blood is the foundation for non-invasive prenatal screening (NIPS). Recently, ultra-short cfDNA fragments, ranging from 30 to 70 base pairs (bp), have been identified and show promise in cancer diagnostics. However, the characteristics of ultra-s...

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Bibliographic Details
Main Authors: Weiqiang Liu, Qin Lu, Weijie Xie, Liang Hu, Lijuan Wen, Shuxian Zeng, Jiatong Zhong, Nani Lin, Yanxiang Chen, Yimin Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Medicine
Subjects:
Ultra-short cfDNA
Pregnancy
Preeclampsia
Early diagnosis
Online Access:https://doi.org/10.1186/s10020-025-01307-1
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