Cell-Penetrating Peptide Based on Myosin Phosphatase Target Subunit Sequence Mediates Myosin Phosphatase Activity

Cell-Penetrating Peptide Based on Myosin Phosphatase Target Subunit Sequence Mediates Myosin Phosphatase Activity

Myosin phosphatase (MP) holoenzyme consists of protein phosphatase-1 (PP1) catalytic subunit (PP1c) associated with myosin phosphatase target subunit-1 (MYPT1) and it plays an important role in mediating the phosphorylation of the 20 kDa light chain (MLC20) of myosin, thereby regulating cell contrac...

Full description

Saved in:

Bibliographic Details
Main Authors:	Andrea Kiss, Mohamad Mahfood, Zsófia Bodogán, Zoltán Kónya, Bálint Bécsi, Ferenc Erdődi
Format:	Article
Language:	English
Published:	MDPI AG 2025-05-01
Series:	Biomolecules
Subjects:	myosin phosphatase protein phosphatase-1 (PP1) catalytic subunit (PP1c) myosin phosphatase target subunit-1 (MYPT1) cell-penetrating MYPT1 peptide transactivating transcriptional activator (TAT)-peptide
Online Access:	https://www.mdpi.com/2218-273X/15/5/705
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The Wheat Intrinsically Disordered Protein <i>Td</i>RL1 Negatively Regulates the Type One Protein Phosphatase <i>Td</i>PP1
by: Fatma Amor, et al.
Published: (2025-04-01)

Considering the effect of Pi rebinding on myosin dynamics based on the distinct functions of cardiac and skeletal myosin
by: Motoshi Kaya
Published: (2025-05-01)

Comparative genomics and synteny analysis of PP2C phosphatases in modern and wild sugarcane cultivars for insights into abiotic stress response
by: Shweta Kumari, et al.
Published: (2025-08-01)

Nanozymes with phosphatase-like activity
by: Yu Cao, et al.
Published: (2025-08-01)

A study of cord blood alkaline phosphatase as a predictor of neonatal hyperbilirubinemia in a tertiary hospital
by: Vijay Baburao Sonawane, et al.
Published: (2025-01-01)

Single and Combined Effects of As (III) and Acetochlor on Phosphatase Activity in Soil
by: Yun ZHANG, et al.
Published: (2013-06-01)

Effects of urea on activity and conformation of acid phosphatase from wheat germ
by: WANG Li-ming, et al.
Published: (2004-05-01)

Recent Advances in Novel Modulators for Cardiac Myosin Disorders
by: Hancheng Wang, et al.

Dysregulation of G protein subunits in autism: decreased GNAO1 and elevated GNAI1 levels in ASD
by: Hatice Topal, et al.
Published: (2025-08-01)

Association between alkaline phosphatase and cancer in American adults: 2003–2016 NHANES
by: Qian Wu, et al.
Published: (2025-07-01)

Alkaline Phosphatase and Parathyroid Hormone Levels: International Variation and Associations With Clinical Outcomes in the DOPPS
by: Suguru Yamamoto, et al.
Published: (2024-04-01)

Research advances of dual-specificity phosphatases in kidney disease
by: 杜宇, et al.
Published: (2021-01-01)

Preliminary Exploration on the Regulatory Mechanism of Ionic Strength on Conformation and Hydration of Silver Carp Myosin
by: Kaiqi Li, et al.
Published: (2025-05-01)

Plant PP2A: A Versatile Enzyme with Key Physiological Functions
by: Juan I. Cortelezzi, et al.
Published: (2025-03-01)

Identification and characterization of alternative homologs of histidinol-phosphate phosphatase in Pseudomonas aeruginosa
by: Wei’an Guo, et al.
Published: (2025-07-01)

Biochemical and Kinetic Studies on Alkaline Phosphatase and other Biochemical Features in Sera of Patients with type 2 Diabetes
by: Baghdad Science Journal
Published: (2012-03-01)

The MAP kinase negative regulator DUSP2 (dual specificity phosphatase 2) is controlled by oncogenic microRNA cluster miR-17-92, miR-106a-363 and miR-106b-25
by: Victoria Tenhaken, et al.
Published: (2025-06-01)

RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis
by: Shu-jie Pang, et al.
Published: (2025-06-01)

A Novel BoHV-1-Vectored Subunit RVFV Vaccine Induces a Robust Humoral and Cell-Mediated Immune Response Against Rift Valley Fever in Sheep
by: Selvaraj Pavulraj, et al.
Published: (2025-02-01)

Beclin‐1‐mediated activation of autophagy improves proximal and distal urea cycle disorders
by: Leandro R Soria, et al.
Published: (2020-12-01)

The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR
by: Aurora Callahan, et al.
Published: (2025-07-01)

From IP3RPEP6 Inhibition of IP3 receptor channels to insights: do channel subunits collaborate or cooperate?
by: Katja Witschas, et al.
Published: (2025-07-01)

Non-canonical activation of MAPK signaling by the lncRNA ASH1L-AS1-encoded microprotein APPLE through inhibition of PP1/PP2A-mediated ERK1/2 dephosphorylation in hepatocellular carcinoma
by: Lei Zhao, et al.
Published: (2025-07-01)

Alkaline phosphatase–streptavidin conjugate (APSA) enzyme and binding activity over time and storage conditions
by: Nan Cheng, et al.
Published: (2025-09-01)

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration
by: Hermien Acx, et al.
Published: (2017-06-01)

Recent advances in the treatment of lupus nephritis
by: Wan-xing Li, et al.
Published: (2022-08-01)

Functional Characterization of MIP_07528 of <i>Mycobacterium indicus pranii</i> for Tyrosine Phosphatase Activity Displays Sensitivity to Oxidative Inactivation and Plays a Role in Immunomodulation
by: Raunak Raunak, et al.
Published: (2025-05-01)

Chronic, Low-Dose Methamphetamine Reveals Sexual Dimorphism of Memory Performance, Histopathology, and Gene Expression Affected by HIV-1 Tat Protein in a Transgenic Model of NeuroHIV
by: Indira S. Harahap-Carrillo, et al.
Published: (2025-02-01)

Results of an investigation of the biochemical markers of bone metabolism in males with rheumatoid arthritis
by: Marina Vasilyevna Letaeva
Published: (2013-12-01)

TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS
by: Yasin Akkuş, et al.
Published: (2023-10-01)

RETROSPECTIVE EVALUATION OF THE CLINICAL COURSE OF PAGET’S DISEASE OF BONE
by: Hülya Hacişahinoğulları, et al.
Published: (2023-10-01)

Dental loss, stress fractures, and musculoskeletal pain in a 48‐year‐old woman
by: Lindsay T. Hoang, et al.
Published: (2023-03-01)

Targeting Streptococcus pyogenes atpF protein for multi-epitope vaccine development: a genomics-driven immunoinformatics strategy
by: Manisha Agarwal, et al.
Published: (2025-09-01)

Dual compartment utility of BRET-based biosensors for PPP2R5A/B56α, a cancer-associated B regulatory subunit of PP2A
by: Hirofumi Yamauchi, et al.
Published: (2025-04-01)

Irradiation of prostate cancer alters circulating small extracellular vesicle functions
by: Aejaz Sayeed, et al.
Published: (2025-07-01)

COMPARATIVE EVALUATION OF OSTEOTROPIC ACTION OF ENDODONTIC FILLING MATERIALS ON THE MODEL OF EXPERIMENTAL DESTRUCTION OF BONE TISSUE OF THE JAW OF RATS
by: I. Han
Published: (2018-03-01)

Protective Effect of Thyme Extract on Albino Rats Exposed to Paraquat
by: Nazar M. Shareef Mahmood
Published: (2022-01-01)

Protective Effect of Thyme Extract on Albino Rats Exposed to Paraquat
by: Nazar M. Shareef Mahmood
Published: (2022-01-01)

Protective Effect of Thyme Extract on Albino Rats Exposed to Paraquat
by: Nazar M. Shareef Mahmood
Published: (2022-01-01)

Protective Effect of Thyme Extract on Albino Rats Exposed to Paraquat
by: Nazar M. Shareef Mahmood
Published: (2022-01-01)