Elevated EGR1 binding at enhancers in excitatory neurons correlates with neuronal subtype-specific epigenetic regulation

Elevated EGR1 binding at enhancers in excitatory neurons correlates with neuronal subtype-specific epigenetic regulation

Abstract Background Brain development and neuronal cell specification are accompanied by epigenetic changes that enable the regulation of diverse gene expression patterns. During these processes, transcription factors interact with cell-type-specific epigenetic marks, binding to unique sets of cis-r...

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Main Authors: Liduo Yin, Xiguang Xu, Benjamin Conacher, Yu Lin, Gabriela L. Carrillo, Yupeng Cun, Michael A. Fox, Xuemei Lu, Hehuang Xie
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Biology
Subjects:
EGR1
Transcription factor
Enhancer
Epigenetic
Excitatory neuron
Inhibitory neuron
Online Access:https://doi.org/10.1186/s12915-025-02357-x
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https://doi.org/10.1186/s12915-025-02357-x

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