Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration
Nanotechnologies bring a rapid paradigm shift in hard and soft bone tissue regeneration (BTR) through unprecedented control over the nanoscale structures and chemistry of biocompatible materials to regenerate the intricate architecture and functional adaptability of bone. This review focuses on the...
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| Format: | Article |
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MDPI AG
2025-08-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/15/15/1198 |
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| author | Nazim Uddin Emon Lu Zhang Shelby Dawn Osborne Mark Allen Lanoue Yan Huang Z. Ryan Tian |
| author_facet | Nazim Uddin Emon Lu Zhang Shelby Dawn Osborne Mark Allen Lanoue Yan Huang Z. Ryan Tian |
| author_sort | Nazim Uddin Emon |
| collection | DOAJ |
| description | Nanotechnologies bring a rapid paradigm shift in hard and soft bone tissue regeneration (BTR) through unprecedented control over the nanoscale structures and chemistry of biocompatible materials to regenerate the intricate architecture and functional adaptability of bone. This review focuses on the transformative analyses and prospects of current and next-generation nanomaterials in designing bioactive bone scaffolds, emphasizing hierarchical architecture, mechanical resilience, and regenerative precision. Mainly, this review elucidated the innovative findings, new capabilities, unmet challenges, and possible future opportunities associated with biocompatible inorganic ceramics (e.g., phosphates, metallic oxides) and the United States Food and Drug Administration (USFDA) approved synthetic polymers, including their nanoscale structures. Furthermore, this review demonstrates the newly available approaches for achieving customized standard porosity, mechanical strengths, and accelerated bioactivity to construct an optimized nanomaterial-oriented scaffold. Numerous strategies including three-dimensional bioprinting, electro-spinning techniques and meticulous nanomaterials (NMs) fabrication are well established to achieve radical scientific precision in BTR engineering. The contemporary research is unceasingly decoding the pathways for spatial and temporal release of osteoinductive agents to enhance targeted therapy and prompt healing processes. Additionally, successful material design and integration of an osteoinductive and osteoconductive agents with the blend of contemporary technologies will bring radical success in this field. Furthermore, machine learning (ML) and artificial intelligence (AI) can further decode the current complexities of material design for BTR, notwithstanding the fact that these methods call for an in-depth understanding of bone composition, relationships and impacts on biochemical processes, distribution of stem cells on the matrix, and functionalization strategies of NMs for better scaffold development. Overall, this review integrated important technological progress with ethical considerations, aiming for a future where nanotechnology-facilitated bone regeneration is boosted by enhanced functionality, safety, inclusivity, and long-term environmental responsibility. Therefore, the assimilation of a specialized research design, while upholding ethical standards, will elucidate the challenge and questions we are presently encountering. |
| format | Article |
| id | doaj-art-d41f6e7d6c70482f88ddc7052fb34d9d |
| institution | Kabale University |
| issn | 2079-4991 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj-art-d41f6e7d6c70482f88ddc7052fb34d9d2025-08-20T04:00:55ZengMDPI AGNanomaterials2079-49912025-08-011515119810.3390/nano15151198Novel Nanomaterials for Developing Bone Scaffolds and Tissue RegenerationNazim Uddin Emon0Lu Zhang1Shelby Dawn Osborne2Mark Allen Lanoue3Yan Huang4Z. Ryan Tian5Cell & Molecular Biology, University of Arkansas, Fayetteville, AR 72701, USACell & Molecular Biology, University of Arkansas, Fayetteville, AR 72701, USAInstitute for Nanoscience & Engineering, University of Arkansas, Fayetteville, AR 72701, USAInstitute for Nanoscience & Engineering, University of Arkansas, Fayetteville, AR 72701, USACell & Molecular Biology, University of Arkansas, Fayetteville, AR 72701, USACell & Molecular Biology, University of Arkansas, Fayetteville, AR 72701, USANanotechnologies bring a rapid paradigm shift in hard and soft bone tissue regeneration (BTR) through unprecedented control over the nanoscale structures and chemistry of biocompatible materials to regenerate the intricate architecture and functional adaptability of bone. This review focuses on the transformative analyses and prospects of current and next-generation nanomaterials in designing bioactive bone scaffolds, emphasizing hierarchical architecture, mechanical resilience, and regenerative precision. Mainly, this review elucidated the innovative findings, new capabilities, unmet challenges, and possible future opportunities associated with biocompatible inorganic ceramics (e.g., phosphates, metallic oxides) and the United States Food and Drug Administration (USFDA) approved synthetic polymers, including their nanoscale structures. Furthermore, this review demonstrates the newly available approaches for achieving customized standard porosity, mechanical strengths, and accelerated bioactivity to construct an optimized nanomaterial-oriented scaffold. Numerous strategies including three-dimensional bioprinting, electro-spinning techniques and meticulous nanomaterials (NMs) fabrication are well established to achieve radical scientific precision in BTR engineering. The contemporary research is unceasingly decoding the pathways for spatial and temporal release of osteoinductive agents to enhance targeted therapy and prompt healing processes. Additionally, successful material design and integration of an osteoinductive and osteoconductive agents with the blend of contemporary technologies will bring radical success in this field. Furthermore, machine learning (ML) and artificial intelligence (AI) can further decode the current complexities of material design for BTR, notwithstanding the fact that these methods call for an in-depth understanding of bone composition, relationships and impacts on biochemical processes, distribution of stem cells on the matrix, and functionalization strategies of NMs for better scaffold development. Overall, this review integrated important technological progress with ethical considerations, aiming for a future where nanotechnology-facilitated bone regeneration is boosted by enhanced functionality, safety, inclusivity, and long-term environmental responsibility. Therefore, the assimilation of a specialized research design, while upholding ethical standards, will elucidate the challenge and questions we are presently encountering.https://www.mdpi.com/2079-4991/15/15/1198inorganic nanomaterialssynthetic polymersbone scaffoldsignaling pathwaysregulatory issuestissue regeneration |
| spellingShingle | Nazim Uddin Emon Lu Zhang Shelby Dawn Osborne Mark Allen Lanoue Yan Huang Z. Ryan Tian Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration Nanomaterials inorganic nanomaterials synthetic polymers bone scaffold signaling pathways regulatory issues tissue regeneration |
| title | Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration |
| title_full | Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration |
| title_fullStr | Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration |
| title_full_unstemmed | Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration |
| title_short | Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration |
| title_sort | novel nanomaterials for developing bone scaffolds and tissue regeneration |
| topic | inorganic nanomaterials synthetic polymers bone scaffold signaling pathways regulatory issues tissue regeneration |
| url | https://www.mdpi.com/2079-4991/15/15/1198 |
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