Factors Affecting the Complete Response in Breast and Axillary Regions Following Neoadjuvant Chemotherapy for Breast Cancer
Aim: Neoadjuvant chemotherapy (NAC) has transitioned from a treatment modality used solely for inoperable and locally advanced breast cancer to a therapeutic approach for early-stage breast cancer. High-risk patients, such as those with HER2-positive and triple-negative breast cancer, particularly b...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2024-09-01
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| Series: | Haseki Tıp Bülteni |
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| Online Access: | https://www.hasekidergisi.com/articles/factors-affecting-the-complete-response-in-breast-and-axillary-regions-following-neoadjuvant-chemotherapy-for-breast-cancer/doi/haseki.galenos.2024.9993 |
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| author | Halit Ozgul Remzi Can Cakir Omer Celik Turan Can Yildiz Erhan Aydemir Betul Dagoglu Hark Azmi Lale |
| author_facet | Halit Ozgul Remzi Can Cakir Omer Celik Turan Can Yildiz Erhan Aydemir Betul Dagoglu Hark Azmi Lale |
| author_sort | Halit Ozgul |
| collection | DOAJ |
| description | Aim: Neoadjuvant chemotherapy (NAC) has transitioned from a treatment modality used solely for inoperable and locally advanced breast cancer to a therapeutic approach for early-stage breast cancer. High-risk patients, such as those with HER2-positive and triple-negative breast cancer, particularly benefit from NAC. This study aimed to evaluate the factors affecting pathological complete response (pCR) in primary breast tumors and axillary lymph nodes in patients with breast cancer.
Methods: The study included female patients with breast cancer who received NAC at a training and research hospital between 2020 and 2024. Patients were categorized based on age, tumor stage, and tumor biology: luminal A, HER2-positive luminal B, HER2-negative luminal B, HER2-positive alone, or triple-negative. The presence or absence of E-cadherin in tumor cells and Ki-67 levels were also examined. Data were obtained from medical records to assess the impact of these factors on complete response in patients with breast cancer and axillary metastatic lymph nodes following NAC.
Results: Univariate analysis revealed that histopathological subtypes, estrogen receptor and progesterone receptor (PR) status, HER2 status, perineural invasion, lymphovascular invasion (LVI), Ki-67 index, and carcinoma in situ (CIS) component significantly influenced pCR. Multivariate analysis confirmed that PR status [Odds ratio (OR): 3.33, 95% confidence interval (CI): 1.57-7.08, p=0.002], HER2 status (OR: 3.56, 95% CI: 1.71-7.44, p=0.001), LVI (OR: 3.91, 95% CI: 1.84-8.30, p<0.001), Ki-67 index (OR: 1.03, 95% CI: 1.01-1.05, p<0.001), and CIS component (OR: 7.01, 95% CI: 2.44-20.11, p<0.001) were independent predictors of complete response.
Conclusion: Our findings underscore the multifaceted nature of NAC response in breast cancer, which is influenced by histopathological and molecular characteristics. |
| format | Article |
| id | doaj-art-d41f5cb45a4a4e42956682ce8cfba9c4 |
| institution | Kabale University |
| issn | 1302-0072 2147-2688 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj-art-d41f5cb45a4a4e42956682ce8cfba9c42024-11-11T07:03:05ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882024-09-0162421622210.4274/haseki.galenos.2024.9993Factors Affecting the Complete Response in Breast and Axillary Regions Following Neoadjuvant Chemotherapy for Breast CancerHalit Ozgul0https://orcid.org/0009-0006-6457-9738Remzi Can Cakir1https://orcid.org/0000-0002-6151-3534Omer Celik2https://orcid.org/0000-0002-4006-2527Turan Can Yildiz3https://orcid.org/0000-0001-5605-2801Erhan Aydemir4https://orcid.org/0000-0003-0430-0142Betul Dagoglu Hark5https://orcid.org/0000-0002-5189-1929Azmi Lale6https://orcid.org/0000-0002-6559-2604University of Health Sciences Turkey, Antalya Training and Research Hospital, Clinic of General Surgery, Antalya, TurkeyHatay Training and Research Hospital, Clinic of General Surgery, Hatay, TurkeyUniversity of Health Sciences Turkey, Antalya Training and Research Hospital, Clinic of General Surgery, Antalya, TurkeyUniversity of Health Sciences Turkey, Antalya Training and Research Hospital, Clinic of General Surgery, Antalya, TurkeyUniversity of Health Sciences Turkey, Antalya Training and Research Hospital, Clinic of General Surgery, Antalya, TurkeyFirat University Faculty of Medicine, Department of Biostatistics and Medical Informatics, Elazig, TurkeyAntalya City Hospital, Clinic of Surgical Oncology, Antalya, TurkeyAim: Neoadjuvant chemotherapy (NAC) has transitioned from a treatment modality used solely for inoperable and locally advanced breast cancer to a therapeutic approach for early-stage breast cancer. High-risk patients, such as those with HER2-positive and triple-negative breast cancer, particularly benefit from NAC. This study aimed to evaluate the factors affecting pathological complete response (pCR) in primary breast tumors and axillary lymph nodes in patients with breast cancer. Methods: The study included female patients with breast cancer who received NAC at a training and research hospital between 2020 and 2024. Patients were categorized based on age, tumor stage, and tumor biology: luminal A, HER2-positive luminal B, HER2-negative luminal B, HER2-positive alone, or triple-negative. The presence or absence of E-cadherin in tumor cells and Ki-67 levels were also examined. Data were obtained from medical records to assess the impact of these factors on complete response in patients with breast cancer and axillary metastatic lymph nodes following NAC. Results: Univariate analysis revealed that histopathological subtypes, estrogen receptor and progesterone receptor (PR) status, HER2 status, perineural invasion, lymphovascular invasion (LVI), Ki-67 index, and carcinoma in situ (CIS) component significantly influenced pCR. Multivariate analysis confirmed that PR status [Odds ratio (OR): 3.33, 95% confidence interval (CI): 1.57-7.08, p=0.002], HER2 status (OR: 3.56, 95% CI: 1.71-7.44, p=0.001), LVI (OR: 3.91, 95% CI: 1.84-8.30, p<0.001), Ki-67 index (OR: 1.03, 95% CI: 1.01-1.05, p<0.001), and CIS component (OR: 7.01, 95% CI: 2.44-20.11, p<0.001) were independent predictors of complete response. Conclusion: Our findings underscore the multifaceted nature of NAC response in breast cancer, which is influenced by histopathological and molecular characteristics.https://www.hasekidergisi.com/articles/factors-affecting-the-complete-response-in-breast-and-axillary-regions-following-neoadjuvant-chemotherapy-for-breast-cancer/doi/haseki.galenos.2024.9993neoadjuvant chemotherapypathological complete responsebreast canceraxillary lymph nodes |
| spellingShingle | Halit Ozgul Remzi Can Cakir Omer Celik Turan Can Yildiz Erhan Aydemir Betul Dagoglu Hark Azmi Lale Factors Affecting the Complete Response in Breast and Axillary Regions Following Neoadjuvant Chemotherapy for Breast Cancer Haseki Tıp Bülteni neoadjuvant chemotherapy pathological complete response breast cancer axillary lymph nodes |
| title | Factors Affecting the Complete Response in Breast and Axillary Regions Following Neoadjuvant Chemotherapy for Breast Cancer |
| title_full | Factors Affecting the Complete Response in Breast and Axillary Regions Following Neoadjuvant Chemotherapy for Breast Cancer |
| title_fullStr | Factors Affecting the Complete Response in Breast and Axillary Regions Following Neoadjuvant Chemotherapy for Breast Cancer |
| title_full_unstemmed | Factors Affecting the Complete Response in Breast and Axillary Regions Following Neoadjuvant Chemotherapy for Breast Cancer |
| title_short | Factors Affecting the Complete Response in Breast and Axillary Regions Following Neoadjuvant Chemotherapy for Breast Cancer |
| title_sort | factors affecting the complete response in breast and axillary regions following neoadjuvant chemotherapy for breast cancer |
| topic | neoadjuvant chemotherapy pathological complete response breast cancer axillary lymph nodes |
| url | https://www.hasekidergisi.com/articles/factors-affecting-the-complete-response-in-breast-and-axillary-regions-following-neoadjuvant-chemotherapy-for-breast-cancer/doi/haseki.galenos.2024.9993 |
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