The synergic impact of decellularized testis scaffold and extracellular vesicles derived from human semen on spermatogonial stem cell survival and differentiation

The synergic impact of decellularized testis scaffold and extracellular vesicles derived from human semen on spermatogonial stem cell survival and differentiation

Abstract Introduction Decellularized scaffolds create a biomimetic niche to support spermatogonial stem cell (SSC) function and engraftment. Semen-derived extracellular vesicles (SEVs), containing proteins, lipids, and microRNAs with various functions, facilitate intercellular communication, enhance...

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Main Authors: Farideh Afshari, Sanaz Alaee, Mahintaj Dara, Mehry Shadi, Noshafarin Chenari, Amin Ramezani, Ali Golestan, Pooneh Mokarram, Tahereh Talaei-Khozani
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BioMedical Engineering OnLine
Subjects:
Decellularized scaffold
Semen
Extracellular vesicles
Spermatogonial stem cells
Testis
Online Access:https://doi.org/10.1186/s12938-025-01424-2
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