Antiplasmodial Activity of Probiotic Limosilactobacillus fermentum YZ01 in Plasmodium berghei ANKA Infected BALB/c Mice
Malaria remains a significant global health challenge, with the deadliest infections caused by Plasmodium falciparum. In light of the escalating drug resistance and the limited effectiveness of available vaccines, innovative treatment approaches are urgently needed. This study explores the potential...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/jotm/6697859 |
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| author | Timothy Bamgbose Afshana Quadri Isa O. Abdullahi Helen I. Inabo Mohammed Bello Lokesh D. Kori Anupkumar R. Anvikar José de la Fuente Elianne Piloto-Sardiñas Alejandro Cabezas-Cruz |
| author_facet | Timothy Bamgbose Afshana Quadri Isa O. Abdullahi Helen I. Inabo Mohammed Bello Lokesh D. Kori Anupkumar R. Anvikar José de la Fuente Elianne Piloto-Sardiñas Alejandro Cabezas-Cruz |
| author_sort | Timothy Bamgbose |
| collection | DOAJ |
| description | Malaria remains a significant global health challenge, with the deadliest infections caused by Plasmodium falciparum. In light of the escalating drug resistance and the limited effectiveness of available vaccines, innovative treatment approaches are urgently needed. This study explores the potential of the probiotic Limosilactobacillus fermentum YZ01, isolated from traditionally fermented kindirmo milk, to modify host responses to Plasmodium berghei ANKA infection. Twenty-five male BALB/c mice were grouped and administered various treatments, including probiotic-enriched yogurt alone or in combination with antibiotics. Parameters assessed included gut lactic acid bacteria (LAB) composition, parasitaemia progression, survival rates, and immune response dynamics over a 21-day postinfection period. The probiotic treatment significantly altered gut microbiota, evidenced by increased LAB counts and modulated immune responses, notably enhancing IgM and IL-4 production while reducing IFN-γ levels. Mice receiving prolonged probiotic treatment exhibited delayed parasitaemia onset, reduced mortality rates, and a more robust immune response compared to control groups. These outcomes suggest that probiotic intervention not only tempers the pathological effects of malaria but also enhances host resilience against infection. This study underscores the role of gut microbiota in infectious disease pathogenesis and supports probiotics as a promising adjunct therapy for malaria management. |
| format | Article |
| id | doaj-art-d40d1230b5b94e45800af5108f0f5ab8 |
| institution | Kabale University |
| issn | 1687-9694 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-d40d1230b5b94e45800af5108f0f5ab82024-12-20T00:00:01ZengWileyJournal of Tropical Medicine1687-96942024-01-01202410.1155/jotm/6697859Antiplasmodial Activity of Probiotic Limosilactobacillus fermentum YZ01 in Plasmodium berghei ANKA Infected BALB/c MiceTimothy Bamgbose0Afshana Quadri1Isa O. Abdullahi2Helen I. Inabo3Mohammed Bello4Lokesh D. Kori5Anupkumar R. Anvikar6José de la Fuente7Elianne Piloto-Sardiñas8Alejandro Cabezas-Cruz9ICMR-National Institute of Malaria ResearchICMR-National Institute of Malaria ResearchDepartment of MicrobiologyDepartment of MicrobiologyDepartment of Veterinary Public Health and Preventive MedicineICMR-National Institute of Malaria ResearchICMR-National Institute of Malaria ResearchSaBio Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCMDirection of Animal HealthANSESMalaria remains a significant global health challenge, with the deadliest infections caused by Plasmodium falciparum. In light of the escalating drug resistance and the limited effectiveness of available vaccines, innovative treatment approaches are urgently needed. This study explores the potential of the probiotic Limosilactobacillus fermentum YZ01, isolated from traditionally fermented kindirmo milk, to modify host responses to Plasmodium berghei ANKA infection. Twenty-five male BALB/c mice were grouped and administered various treatments, including probiotic-enriched yogurt alone or in combination with antibiotics. Parameters assessed included gut lactic acid bacteria (LAB) composition, parasitaemia progression, survival rates, and immune response dynamics over a 21-day postinfection period. The probiotic treatment significantly altered gut microbiota, evidenced by increased LAB counts and modulated immune responses, notably enhancing IgM and IL-4 production while reducing IFN-γ levels. Mice receiving prolonged probiotic treatment exhibited delayed parasitaemia onset, reduced mortality rates, and a more robust immune response compared to control groups. These outcomes suggest that probiotic intervention not only tempers the pathological effects of malaria but also enhances host resilience against infection. This study underscores the role of gut microbiota in infectious disease pathogenesis and supports probiotics as a promising adjunct therapy for malaria management.http://dx.doi.org/10.1155/jotm/6697859 |
| spellingShingle | Timothy Bamgbose Afshana Quadri Isa O. Abdullahi Helen I. Inabo Mohammed Bello Lokesh D. Kori Anupkumar R. Anvikar José de la Fuente Elianne Piloto-Sardiñas Alejandro Cabezas-Cruz Antiplasmodial Activity of Probiotic Limosilactobacillus fermentum YZ01 in Plasmodium berghei ANKA Infected BALB/c Mice Journal of Tropical Medicine |
| title | Antiplasmodial Activity of Probiotic Limosilactobacillus fermentum YZ01 in Plasmodium berghei ANKA Infected BALB/c Mice |
| title_full | Antiplasmodial Activity of Probiotic Limosilactobacillus fermentum YZ01 in Plasmodium berghei ANKA Infected BALB/c Mice |
| title_fullStr | Antiplasmodial Activity of Probiotic Limosilactobacillus fermentum YZ01 in Plasmodium berghei ANKA Infected BALB/c Mice |
| title_full_unstemmed | Antiplasmodial Activity of Probiotic Limosilactobacillus fermentum YZ01 in Plasmodium berghei ANKA Infected BALB/c Mice |
| title_short | Antiplasmodial Activity of Probiotic Limosilactobacillus fermentum YZ01 in Plasmodium berghei ANKA Infected BALB/c Mice |
| title_sort | antiplasmodial activity of probiotic limosilactobacillus fermentum yz01 in plasmodium berghei anka infected balb c mice |
| url | http://dx.doi.org/10.1155/jotm/6697859 |
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