Metabolic landscape of clear cell renal cell carcinoma and search for metabolites predictive of drug response

Metabolic landscape of clear cell renal cell carcinoma and search for metabolites predictive of drug response

Abstract Background Clear cell renal cell carcinoma (ccRCC) commonly exhibits biallelic inactivation of VHL genes, profoundly impacting intracellular metabolic pathways and utilization of metabolic substrates. The aims of this study were to validate the metabolomic profile previously identified in c...

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Main Authors: Michinobu Ozawa, Sei Naito, Hideki Makinoshima, Hiromi Ito, Atsushi Tsuya, Takafumi Narisawa, Hiroki Fukuhara, Yuki Takai, Masaki Ushijima, Mayu Yagi, Hayato Nishida, Norihiko Tsuchiya
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Biomarker
Clear cell renal cell carcinoma
Kidney cancer
Metabolome.
Online Access:https://doi.org/10.1186/s12885-025-14661-4
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https://doi.org/10.1186/s12885-025-14661-4

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