Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises
Molecular imaging is an attractive platform for noninvasive detection and assessment of cancer. In recent years, the targeted imaging of the C–X–C chemokine receptor 4 (CXCR4), a chemokine receptor that has been associated with tumor metastasis, has become an area of intensive research. This review...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-01-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2014.00041 |
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| _version_ | 1841564131887415296 |
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| author | Guillaume Pierre Charles George Federica Pisaneschi Quang-Dé Nguyen Eric Ofori Aboagye |
| author_facet | Guillaume Pierre Charles George Federica Pisaneschi Quang-Dé Nguyen Eric Ofori Aboagye |
| author_sort | Guillaume Pierre Charles George |
| collection | DOAJ |
| description | Molecular imaging is an attractive platform for noninvasive detection and assessment of cancer. In recent years, the targeted imaging of the C–X–C chemokine receptor 4 (CXCR4), a chemokine receptor that has been associated with tumor metastasis, has become an area of intensive research. This review article focuses on positron emission tomography (PET) and aims to provide useful and critical insights into the application of PET to characterize CXCR4 expression, including the chemical, radiosynthetic, and biological requirements for PET radiotracers. This discussion is informed by a summary of the different approaches taken so far and a comparison of their clinical translation. Finally, our expert opinions as to potential future advances in the field are expressed. |
| format | Article |
| id | doaj-art-d4075b4979d449bb8ab1152070228406 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-d4075b4979d449bb8ab11520702284062025-01-02T23:12:08ZengSAGE PublishingMolecular Imaging1536-01212015-01-011410.2310/7290.2014.0004110.2310_7290.2014.00041Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and PromisesGuillaume Pierre Charles GeorgeFederica PisaneschiQuang-Dé NguyenEric Ofori AboagyeMolecular imaging is an attractive platform for noninvasive detection and assessment of cancer. In recent years, the targeted imaging of the C–X–C chemokine receptor 4 (CXCR4), a chemokine receptor that has been associated with tumor metastasis, has become an area of intensive research. This review article focuses on positron emission tomography (PET) and aims to provide useful and critical insights into the application of PET to characterize CXCR4 expression, including the chemical, radiosynthetic, and biological requirements for PET radiotracers. This discussion is informed by a summary of the different approaches taken so far and a comparison of their clinical translation. Finally, our expert opinions as to potential future advances in the field are expressed.https://doi.org/10.2310/7290.2014.00041 |
| spellingShingle | Guillaume Pierre Charles George Federica Pisaneschi Quang-Dé Nguyen Eric Ofori Aboagye Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises Molecular Imaging |
| title | Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises |
| title_full | Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises |
| title_fullStr | Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises |
| title_full_unstemmed | Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises |
| title_short | Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises |
| title_sort | positron emission tomographic imaging of cxcr4 in cancer challenges and promises |
| url | https://doi.org/10.2310/7290.2014.00041 |
| work_keys_str_mv | AT guillaumepierrecharlesgeorge positronemissiontomographicimagingofcxcr4incancerchallengesandpromises AT federicapisaneschi positronemissiontomographicimagingofcxcr4incancerchallengesandpromises AT quangdenguyen positronemissiontomographicimagingofcxcr4incancerchallengesandpromises AT ericoforiaboagye positronemissiontomographicimagingofcxcr4incancerchallengesandpromises |