Update of the risk assessment of inorganic arsenic in food
Abstract The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | EFSA Journal |
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| Online Access: | https://doi.org/10.2903/j.efsa.2024.8488 |
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| author | EFSA Panel on Contaminants in the Food Chain (CONTAM) Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús delMazo Bettina Grasl‐Kraupp Christer Hogstrand Laurentius (Ron) Hoogenboom Jean‐Charles Leblanc Carlo Stefano Nebbia Elsa Nielsen Evangelia Ntzani Annette Petersen Salomon Sand Christiane Vleminckx Heather Wallace Lars Barregård Diane Benford Karin Broberg Eugenia Dogliotti Tony Fletcher Lars Rylander José Cortiñas Abrahantes Jose Ángel Gómez Ruiz Hans Steinkellner Tuuli Tauriainen Tanja Schwerdtle |
| author_facet | EFSA Panel on Contaminants in the Food Chain (CONTAM) Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús delMazo Bettina Grasl‐Kraupp Christer Hogstrand Laurentius (Ron) Hoogenboom Jean‐Charles Leblanc Carlo Stefano Nebbia Elsa Nielsen Evangelia Ntzani Annette Petersen Salomon Sand Christiane Vleminckx Heather Wallace Lars Barregård Diane Benford Karin Broberg Eugenia Dogliotti Tony Fletcher Lars Rylander José Cortiñas Abrahantes Jose Ángel Gómez Ruiz Hans Steinkellner Tuuli Tauriainen Tanja Schwerdtle |
| author_sort | EFSA Panel on Contaminants in the Food Chain (CONTAM) |
| collection | DOAJ |
| description | Abstract The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL05) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CONTAM Panel applied a margin of exposure (MOE) approach for the risk characterisation. In adults, the MOEs are low (range between 2 and 0.4 for mean consumers and between 0.9 and 0.2 at the 95th percentile exposure, respectively) and as such raise a health concern despite the uncertainties. |
| format | Article |
| id | doaj-art-d4014f0c32b747e1a22dd5b22c842fef |
| institution | Kabale University |
| issn | 1831-4732 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-d4014f0c32b747e1a22dd5b22c842fef2024-11-13T07:31:25ZengWileyEFSA Journal1831-47322024-01-01221n/an/a10.2903/j.efsa.2024.8488Update of the risk assessment of inorganic arsenic in foodEFSA Panel on Contaminants in the Food Chain (CONTAM)Dieter SchrenkMargherita BignamiLaurent BodinJames Kevin ChipmanJesús delMazoBettina Grasl‐KrauppChrister HogstrandLaurentius (Ron) HoogenboomJean‐Charles LeblancCarlo Stefano NebbiaElsa NielsenEvangelia NtzaniAnnette PetersenSalomon SandChristiane VleminckxHeather WallaceLars BarregårdDiane BenfordKarin BrobergEugenia DogliottiTony FletcherLars RylanderJosé Cortiñas AbrahantesJose Ángel Gómez RuizHans SteinkellnerTuuli TauriainenTanja SchwerdtleAbstract The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL05) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CONTAM Panel applied a margin of exposure (MOE) approach for the risk characterisation. In adults, the MOEs are low (range between 2 and 0.4 for mean consumers and between 0.9 and 0.2 at the 95th percentile exposure, respectively) and as such raise a health concern despite the uncertainties.https://doi.org/10.2903/j.efsa.2024.8488benchmark dose (BMD)epidemiological studiesinorganic arsenic (iAs)margin of exposure (MOE)risk assessment |
| spellingShingle | EFSA Panel on Contaminants in the Food Chain (CONTAM) Dieter Schrenk Margherita Bignami Laurent Bodin James Kevin Chipman Jesús delMazo Bettina Grasl‐Kraupp Christer Hogstrand Laurentius (Ron) Hoogenboom Jean‐Charles Leblanc Carlo Stefano Nebbia Elsa Nielsen Evangelia Ntzani Annette Petersen Salomon Sand Christiane Vleminckx Heather Wallace Lars Barregård Diane Benford Karin Broberg Eugenia Dogliotti Tony Fletcher Lars Rylander José Cortiñas Abrahantes Jose Ángel Gómez Ruiz Hans Steinkellner Tuuli Tauriainen Tanja Schwerdtle Update of the risk assessment of inorganic arsenic in food EFSA Journal benchmark dose (BMD) epidemiological studies inorganic arsenic (iAs) margin of exposure (MOE) risk assessment |
| title | Update of the risk assessment of inorganic arsenic in food |
| title_full | Update of the risk assessment of inorganic arsenic in food |
| title_fullStr | Update of the risk assessment of inorganic arsenic in food |
| title_full_unstemmed | Update of the risk assessment of inorganic arsenic in food |
| title_short | Update of the risk assessment of inorganic arsenic in food |
| title_sort | update of the risk assessment of inorganic arsenic in food |
| topic | benchmark dose (BMD) epidemiological studies inorganic arsenic (iAs) margin of exposure (MOE) risk assessment |
| url | https://doi.org/10.2903/j.efsa.2024.8488 |
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