Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman
We report a case of 33-year-old woman with a 4-year primary infertility. A high isolated follicle-stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify im...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/3071649 |
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| author | Aurore Catteau Kalyane Bach-Ngohou Justine Blin Paul Barrière Thomas Fréour Damien Masson |
| author_facet | Aurore Catteau Kalyane Bach-Ngohou Justine Blin Paul Barrière Thomas Fréour Damien Masson |
| author_sort | Aurore Catteau |
| collection | DOAJ |
| description | We report a case of 33-year-old woman with a 4-year primary infertility. A high isolated follicle-stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify immune complexes involving FSH. The PEG precipitation test revealed that the high FSH level was almost exclusively due to the presence of autoimmune FSH immunoglobulin complex (macro-FSH). The profile obtained by gel filtration chromatography confirmed the presence of an FSH-immunoglobulin complex. Such immunological dysregulation could be explored in cases of unexplained infertility and recurrent IVF failure. |
| format | Article |
| id | doaj-art-d3edfcee22db48158626c903e5e3f4e8 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-d3edfcee22db48158626c903e5e3f4e82025-02-03T05:47:29ZengWileyCase Reports in Endocrinology2090-65012090-651X2019-01-01201910.1155/2019/30716493071649Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile WomanAurore Catteau0Kalyane Bach-Ngohou1Justine Blin2Paul Barrière3Thomas Fréour4Damien Masson5Laboratoire de biochimie, Institut de Biologie, CHU de Nantes, Nantes, FranceLaboratoire de biochimie, Institut de Biologie, CHU de Nantes, Nantes, FranceLaboratoire de biochimie, Institut de Biologie, CHU de Nantes, Nantes, FranceFaculté de médecine, Université de Nantes, Nantes, FranceFaculté de médecine, Université de Nantes, Nantes, FranceLaboratoire de biochimie, Institut de Biologie, CHU de Nantes, Nantes, FranceWe report a case of 33-year-old woman with a 4-year primary infertility. A high isolated follicle-stimulating hormone (FSH) level was conflicting with the clinical situation and with other hormonal markers which were in favor of polycystic ovarian syndrome. We followed a strategy used to identify immune complexes involving FSH. The PEG precipitation test revealed that the high FSH level was almost exclusively due to the presence of autoimmune FSH immunoglobulin complex (macro-FSH). The profile obtained by gel filtration chromatography confirmed the presence of an FSH-immunoglobulin complex. Such immunological dysregulation could be explored in cases of unexplained infertility and recurrent IVF failure.http://dx.doi.org/10.1155/2019/3071649 |
| spellingShingle | Aurore Catteau Kalyane Bach-Ngohou Justine Blin Paul Barrière Thomas Fréour Damien Masson Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman Case Reports in Endocrinology |
| title | Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman |
| title_full | Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman |
| title_fullStr | Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman |
| title_full_unstemmed | Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman |
| title_short | Abnormally Elevated Follicle-Stimulating Hormone (FSH) Level in an Infertile Woman |
| title_sort | abnormally elevated follicle stimulating hormone fsh level in an infertile woman |
| url | http://dx.doi.org/10.1155/2019/3071649 |
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