Global and regional burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria in 2019: A systematic analysis from the MICROBE database
Objectives: To quantify the global and regional burden of bloodstream infections associated with and attributable to carbapenem-resistant Gram-negative bacteria. Methods: We extracted data from the Measuring Infectious Causes and Resistance Outcomes for Burden Estimation database, which includes the...
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| Format: | Article |
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Elsevier
2025-04-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224008440 |
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| author | Lei Zha Shirong Li Jun Guo Yixin Hu Lingling Pan Hanli Wang Yun Zhou Qiancheng Xu Zhiwei Lu Xiang Kong Xinzhao Tong Yusheng Cheng |
| author_facet | Lei Zha Shirong Li Jun Guo Yixin Hu Lingling Pan Hanli Wang Yun Zhou Qiancheng Xu Zhiwei Lu Xiang Kong Xinzhao Tong Yusheng Cheng |
| author_sort | Lei Zha |
| collection | DOAJ |
| description | Objectives: To quantify the global and regional burden of bloodstream infections associated with and attributable to carbapenem-resistant Gram-negative bacteria. Methods: We extracted data from the Measuring Infectious Causes and Resistance Outcomes for Burden Estimation database, which includes the estimated burden of 23 pathogens and 88 pathogen-drug combinations across 12 major infectious syndromes globally in 2019. The number and rate of deaths, as well as disability-adjusted life-years linked to bloodstream infections, were systematically analyzed. Results: In 2019, bloodstream infections accounted for approximately 2.91 (95% UI, 1.74-4.53) million deaths globally, with Gram-negative bacteria responsible for 51.1% of these fatalities. An estimated 391,800 (95% UI 221,500-631,400) deaths were associated with carbapenem resistance, constituting 26.3% of all bloodstream infection-related deaths. The highest burden of carbapenem resistance was seen in South Asia, East Asia, and Eastern Europe, while the lowest burden was in Sub-Saharan Africa. Notably, Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the leading carbapenem-resistant pathogens contributing to mortality. Conclusions: Our findings underscore the significant global burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria, with notable regional disparities. There is an urgent need for enhanced surveillance, improved infection prevention and control measures, and better access to first-line antibiotics, particularly in high-burden regions. |
| format | Article |
| id | doaj-art-d3e955ecfc694d8ba9ea90526a279a84 |
| institution | Kabale University |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-d3e955ecfc694d8ba9ea90526a279a842025-01-11T06:38:38ZengElsevierInternational Journal of Infectious Diseases1201-97122025-04-01153107769Global and regional burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria in 2019: A systematic analysis from the MICROBE databaseLei Zha0Shirong Li1Jun Guo2Yixin Hu3Lingling Pan4Hanli Wang5Yun Zhou6Qiancheng Xu7Zhiwei Lu8Xiang Kong9Xinzhao Tong10Yusheng Cheng11Department of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaPulmonary and Critical Care Department, The Second People's Hospital of Wuhu, Wuhu, Anhui, ChinaDepartment of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, ChinaCardiology Department, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaDepartment of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaPulmonary and Critical Care Department, The Second People's Hospital of Wuhu, Wuhu, Anhui, ChinaIntensive Care Unit, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaDepartment of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaDepartment of Gerontology, Geriatric Endocrinology Unit, The First Affiliated Hospital of Wannan Medical College, Wuhu, ChinaDepartment of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, ChinaDepartment of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China; Corresponding author: Yusheng Cheng, Department of Respiratory Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, China.Objectives: To quantify the global and regional burden of bloodstream infections associated with and attributable to carbapenem-resistant Gram-negative bacteria. Methods: We extracted data from the Measuring Infectious Causes and Resistance Outcomes for Burden Estimation database, which includes the estimated burden of 23 pathogens and 88 pathogen-drug combinations across 12 major infectious syndromes globally in 2019. The number and rate of deaths, as well as disability-adjusted life-years linked to bloodstream infections, were systematically analyzed. Results: In 2019, bloodstream infections accounted for approximately 2.91 (95% UI, 1.74-4.53) million deaths globally, with Gram-negative bacteria responsible for 51.1% of these fatalities. An estimated 391,800 (95% UI 221,500-631,400) deaths were associated with carbapenem resistance, constituting 26.3% of all bloodstream infection-related deaths. The highest burden of carbapenem resistance was seen in South Asia, East Asia, and Eastern Europe, while the lowest burden was in Sub-Saharan Africa. Notably, Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the leading carbapenem-resistant pathogens contributing to mortality. Conclusions: Our findings underscore the significant global burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria, with notable regional disparities. There is an urgent need for enhanced surveillance, improved infection prevention and control measures, and better access to first-line antibiotics, particularly in high-burden regions.http://www.sciencedirect.com/science/article/pii/S1201971224008440Antimicrobial resistanceBloodstream infectionBacteremiaCarbapenem resistanceGram-negative bacteriaDisease burden |
| spellingShingle | Lei Zha Shirong Li Jun Guo Yixin Hu Lingling Pan Hanli Wang Yun Zhou Qiancheng Xu Zhiwei Lu Xiang Kong Xinzhao Tong Yusheng Cheng Global and regional burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria in 2019: A systematic analysis from the MICROBE database International Journal of Infectious Diseases Antimicrobial resistance Bloodstream infection Bacteremia Carbapenem resistance Gram-negative bacteria Disease burden |
| title | Global and regional burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria in 2019: A systematic analysis from the MICROBE database |
| title_full | Global and regional burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria in 2019: A systematic analysis from the MICROBE database |
| title_fullStr | Global and regional burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria in 2019: A systematic analysis from the MICROBE database |
| title_full_unstemmed | Global and regional burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria in 2019: A systematic analysis from the MICROBE database |
| title_short | Global and regional burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria in 2019: A systematic analysis from the MICROBE database |
| title_sort | global and regional burden of bloodstream infections caused by carbapenem resistant gram negative bacteria in 2019 a systematic analysis from the microbe database |
| topic | Antimicrobial resistance Bloodstream infection Bacteremia Carbapenem resistance Gram-negative bacteria Disease burden |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224008440 |
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