In silico and cheminformatics prediction with experimental validation of an adipogenesis cocktail, sorafenib with rosiglitazone for HCC dedifferentiation

In silico and cheminformatics prediction with experimental validation of an adipogenesis cocktail, sorafenib with rosiglitazone for HCC dedifferentiation

Purpose: Hepatocellular carcinoma (HCC) resistance to sorafenib treatment and other treatment strategies causes a higher mortality rate in patients diagnosed with HCC.Research question.HCC often develops resistance to sorafenib treatment and other therapies, leading to increased mortality rates in d...

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Bibliographic Details
Main Authors: Aya Anis, Ahmed M. Mostafa, Mariam S. Kerema, Nadia M. Hamdy, Ahmed S. Sultan
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
Rosiglitazone
Insulin
IBMX, PPARγ
HCC
Sorafenib
Adipogenesis-inducer
Online Access:http://www.sciencedirect.com/science/article/pii/S1687157X2400132X
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