The evaluation of pharmacokinetic parameters of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide and its metabolites in rat plasma

The evaluation of pharmacokinetic parameters of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide and its metabolites in rat plasma

Introduction: 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide (ODASA) is a new pharmacologically activecompound, which is capable of reducing intraocular pressure by inhibiting carbonic anhydrase II. It is necessary to calculate the pharmacokinetic parameters of this compound and its metabolit...

Full description

Saved in:

Bibliographic Details
Main Authors:	Alexander L. Khokhlov, Ilya I. Yaichkov, Anton A. Shetnev, Mikhail K. Korsakov, Nikita N. Volkhin, Sergey S. Petukhov, Alena N. Tyushina, Olga E. Lasaryanz
Format:	Article
Language:	English
Published:	Belgorod National Research University 2024-12-01
Series:	Research Results in Pharmacology
Subjects:	hplc-ms/ms plasma stabilization validation pharmacokinetics bioavailability rats carbonic anhydrase ii inhibitor n-hydroxysulfonamide
Online Access:	https://rrpharmacology.ru/index.php/journal/article/view/523
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The Identification and synthesis of metabolites of 4-(5-methyl-1,3,4-oxadiazole-2-yl)-benzenesulfonamide
by: Alexander L. Khokhlov, et al.
Published: (2024-11-01)

Quantitative analysis and pharmacokinetic study of a novel diarylurea EGFR inhibitor (ZCJ14) in rat plasma using a validated LC-MS/MS method
by: Zuo Sai-Jie, et al.
Published: (2021-09-01)

Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents
by: Tulika Anthwal, et al.
Published: (2025-02-01)

Purification and characterization of lipase from Bacillus subtilis kubt4 for biodiesel production
by: Parveen Nadaf, et al.
Published: (2025-01-01)

Synthesis of N-[{5-Aryl-1,3,4-oxadiazole-2-yl}methyl]-4-methoxyaniline Derivatives and Their Anticonvulsant Activity
by: B. N. Prasanna Kumar, et al.
Published: (2013-01-01)

Isoniazid urine spectrophotometry for prediction of serum pharmacokinetics in adults with TB
by: P. S. Rao, et al.
Published: (2024-02-01)

Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine setting of oxygen/glucose deprivation followed by re-oxygenation and is associated with improved neuronal function in ischemic rats
by: Sara Amiranda, et al.
Published: (2025-02-01)

Discovery of novel serum peptide biomarkers for cholangiocarcinoma recurrence through MALDI-TOF MS and LC–MS/MS peptidome analysis
by: Vasin Thanasukarn, et al.
Published: (2025-01-01)

Identification and pharmacokinetics of saponins in Rhizoma Anemarrhenae after oral administration to rats by HPLC-Q-TOF/MS and HPLC-MS/MS
by: Wang Hai-Qiao, et al.
Published: (2021-12-01)

Environmental Applications of Mass Spectrometry for Emerging Contaminants
by: Anil Kumar Meher, et al.
Published: (2025-01-01)

Network-Based Protein Biomarker Discovery Platforms
by: Minhyung Kim, et al.
Published: (2016-03-01)

LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia
by: Mihaela Butiulca, et al.
Published: (2025-01-01)

Determination of clostebol residues in the urine of slaughter animals using liquid chromatography–tandem mass spectrometry
by: Matraszek-Żuchowska Iwona, et al.
Published: (2024-12-01)

Simultaneous determination of nirmatrelvir, ritonavir, and beta-D-N4-hydroxycytidine in human plasma and epithelial lining fluid using LC-MS/MS and its clinical application to compare rates of achieving effective concentrations
by: Wenjing Zhang, et al.
Published: (2025-01-01)

Expression and localization of two β-carbonic anhydrases in Bienertia, a single-cell C4 plant
by: Tho Nguyen, et al.
Published: (2025-01-01)

Characterization of Anthocyanins Including Acetylated Glycosides from Highbush Blueberry (<i>Vaccinium corymbosum</i> L.) Cultivated in Korea Based on UPLC-DAD-QToF/MS and UPLC-Qtrap-MS/MS
by: Ju Hyung Kim, et al.
Published: (2025-01-01)

The critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network
by: Yi Wang, et al.
Published: (2025-01-01)

Development and Validation of a Robust and Straightforward LC-MS Method for Measuring Taurine in Whole Blood and Plasma of Dogs and Reference Intervals Calculation
by: Tommaso Furlanello, et al.
Published: (2024-12-01)

Factors affecting fatigue progression in multiple sclerosis patients
by: Dima Machtoub, et al.
Published: (2024-12-01)

Mechanism of melanoma suppression by Prosopis juliflora derived alkaloids: Apoptosis induction and signaling pathway inhibition
by: Jasoda Choudhari, et al.
Published: (2025-02-01)

Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study
by: Li X, et al.
Published: (2025-02-01)

Validation of Colchicine Assay Method for Therapeutic Drug Monitoring in Human Plasma
by: Fadime Canbolat
Published: (2022-12-01)

Evaluation of Malathion and Malaoxon Contamination in Buffalo and Cow Milk from Afyonkarahisar Region, Turkey, Using Liquid Chromatography/Tandem Mass Spectrometry – a Short Report
by: Kara Recep, et al.
Published: (2016-03-01)

Stability study of thymoquinone, carvacrol and thymol using HPLC-UV and LC-ESI-MS
by: Soliman Rabab M., et al.
Published: (2020-09-01)

Dual-frequency ultrasonic oxidation of cyanobacterial toxins (MC-LR and MC-RR) at drinking water resources: Assessment of analytical methods and ultrasonic reactor configuration
by: Zeynep Eren
Published: (2025-02-01)

Metabolite profile of Passiflora mollisima leaf using UHPLC-ESI-MS and its potential anxiolytic activity in mice
by: Carmen Luisa Marìn-Tello, et al.
Published: (2024-12-01)

A sterol panel for rare lipid disorders: sitosterolemia, cerebrotendinous xanthomatosis and Smith-Lemli-Opitz syndrome
by: Alexander Bauer Westbye, et al.
Published: (2025-01-01)

Proteomic Analysis of the Murine Liver Response to Oral Exposure to Aflatoxin B1 and Ochratoxin A: The Protective Role to Bioactive Compounds
by: Silvia Trombetti, et al.
Published: (2025-01-01)

Concurrent Extraction and Analysis of Atmospheric Particulate Matter-bound PBDEs, PAHs, Nitrated PAHs, and OPEs
by: Hsin-Chieh Kung, et al.
Published: (2023-12-01)

Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics
by: David Chamoso-Sanchez, et al.
Published: (2025-01-01)

Valorization of local regional apple (Malus domestica Borkh.) cultivars versus commercial samples from Spain: Phenolic compounds by HPLC-MS/MS, cytotoxicity and biological potential on nitric oxide radicals and lipoxygenase inhibition
by: Adrián Millán-Laleona, et al.
Published: (2025-01-01)

Elucidation of peptide screen for targeted identification of Yersinia pestis by nano-liquid chromatography tandem mass spectrometry
by: Priya Rani, et al.
Published: (2025-01-01)

A comprehensive investigation of Clerodendrum Infortunatum Linn. using LC-QTOF-MS/MS metabolomics as a promising anti-alzheimer candidate
by: Fatma Atef, et al.
Published: (2025-01-01)

Retraction Note: Novel and efficient process for the synthesis of 1,3,4 Oxadiazole containing MBX-4132
by: Prachi Ramteke, et al.

Characteristics and bioinformatics of peptides from natural and cultured sandfish (Holothuria scabra)
by: Pawitporn Daopa, et al.
Published: (2025-06-01)

Development and application of an efficient, accurate, and environmentally friendly liquid chromatography–tandem mass spectrometry method for the determination of five Alternaria toxins in wheat
by: Huiyuan Lang, et al.
Published: (2025-01-01)

New LC-MS/MS method for the determination of unconventional organic pollutants: perfluoroalkyl sulfonic acids in wastewater, surface water, and drinking water
by: Florentina Laura Chiriac, et al.
Published: (2024-12-01)

Simultaneous determination of 74 pesticide residues in Panax notoginseng by QuEChERS coupled with gas chromatography tandem mass spectrometry
by: Huijun Li, et al.
Published: (2021-03-01)

Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay
by: Linlin Dong, et al.
Published: (2024-12-01)

UHPLC-MS/MS based comprehensive phenolic profiling, antimicrobial and antioxidant activities of Indian Rhodomyrtus tomentosa fruits
by: A Divya Priya, et al.
Published: (2025-01-01)