Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health
Abstract Mosquito-borne flaviviruses represent a public health challenge due to the high-rate endemic infections, severe clinical outcomes, and the potential risk of emerging global outbreaks. Flavivirus disease pathogenesis converges on cellular factors from vectors and hosts, and their interaction...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Biomedical Science |
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| Online Access: | https://doi.org/10.1186/s12929-024-01096-5 |
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| author | Pedro Pablo Martínez-Rojas Verónica Monroy-Martínez Blanca H. Ruiz-Ordaz |
| author_facet | Pedro Pablo Martínez-Rojas Verónica Monroy-Martínez Blanca H. Ruiz-Ordaz |
| author_sort | Pedro Pablo Martínez-Rojas |
| collection | DOAJ |
| description | Abstract Mosquito-borne flaviviruses represent a public health challenge due to the high-rate endemic infections, severe clinical outcomes, and the potential risk of emerging global outbreaks. Flavivirus disease pathogenesis converges on cellular factors from vectors and hosts, and their interactions are still unclear. Exosomes and microparticles are extracellular vesicles released from cells that mediate the intercellular communication necessary for maintaining homeostasis; however, they have been shown to be involved in disease establishment and progression. This review focuses on the roles of extracellular vesicles in the pathogenesis of mosquito-borne flavivirus diseases: how they contribute to viral cycle completion, cell-to-cell transmission, and cellular responses such as inflammation, immune suppression, and evasion, as well as their potential use as biomarkers or therapeutics (antiviral or vaccines). We highlight the current findings concerning the functionality of extracellular vesicles in different models of dengue virus, Zika virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus infections and diseases. The available evidence suggests that extracellular vesicles mediate diverse functions between hosts, constituting novel effectors for understanding the pathogenic mechanisms of flaviviral diseases. |
| format | Article |
| id | doaj-art-d3a55e9c0cb2416493b57fe81b69b29a |
| institution | Kabale University |
| issn | 1423-0127 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj-art-d3a55e9c0cb2416493b57fe81b69b29a2025-01-05T12:42:29ZengBMCJournal of Biomedical Science1423-01272025-01-0132112210.1186/s12929-024-01096-5Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public healthPedro Pablo Martínez-Rojas0Verónica Monroy-Martínez1Blanca H. Ruiz-Ordaz2Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM)Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM)Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM)Abstract Mosquito-borne flaviviruses represent a public health challenge due to the high-rate endemic infections, severe clinical outcomes, and the potential risk of emerging global outbreaks. Flavivirus disease pathogenesis converges on cellular factors from vectors and hosts, and their interactions are still unclear. Exosomes and microparticles are extracellular vesicles released from cells that mediate the intercellular communication necessary for maintaining homeostasis; however, they have been shown to be involved in disease establishment and progression. This review focuses on the roles of extracellular vesicles in the pathogenesis of mosquito-borne flavivirus diseases: how they contribute to viral cycle completion, cell-to-cell transmission, and cellular responses such as inflammation, immune suppression, and evasion, as well as their potential use as biomarkers or therapeutics (antiviral or vaccines). We highlight the current findings concerning the functionality of extracellular vesicles in different models of dengue virus, Zika virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus infections and diseases. The available evidence suggests that extracellular vesicles mediate diverse functions between hosts, constituting novel effectors for understanding the pathogenic mechanisms of flaviviral diseases.https://doi.org/10.1186/s12929-024-01096-5ArbovirusFlavivirusMosquito-borne flavivirusesFlavivirus pathogenesisExtracellular vesiclesExosomes |
| spellingShingle | Pedro Pablo Martínez-Rojas Verónica Monroy-Martínez Blanca H. Ruiz-Ordaz Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health Journal of Biomedical Science Arbovirus Flavivirus Mosquito-borne flaviviruses Flavivirus pathogenesis Extracellular vesicles Exosomes |
| title | Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health |
| title_full | Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health |
| title_fullStr | Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health |
| title_full_unstemmed | Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health |
| title_short | Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health |
| title_sort | role of extracellular vesicles in the pathogenesis of mosquito borne flaviviruses that impact public health |
| topic | Arbovirus Flavivirus Mosquito-borne flaviviruses Flavivirus pathogenesis Extracellular vesicles Exosomes |
| url | https://doi.org/10.1186/s12929-024-01096-5 |
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