Simultaneous determination of nirmatrelvir, ritonavir, and beta-D-N4-hydroxycytidine in human plasma and epithelial lining fluid using LC-MS/MS and its clinical application to compare rates of achieving effective concentrations

Simultaneous determination of nirmatrelvir, ritonavir, and beta-D-N4-hydroxycytidine in human plasma and epithelial lining fluid using LC-MS/MS and its clinical application to compare rates of achieving effective concentrations

Currently, the trials found that the clinical efficacy of molnupiravir is lower than ritonavir-boosted nirmatrelvir. An explanation for these different efficacies in clinical treatments is still limited. The analysis method was developed and validated to simultaneously quantify nirmatrelvir, ritonav...

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Bibliographic Details
Main Authors: Wenjing Zhang, Lin Xia, Zhilong Yuan, Mengdan Liu, Yang Jiao, Zhuo Wang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
COVD-19
LC-MS/MS
Nirmatrelvir
Ritonavir
Beta-D-N4-hydroxycytidine
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025001173
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