On the Pathogenesis of the Irritable Bowel Syndrome: The Irritable Bowel or the Irritable Patient?
The traditional perspective of irritable bowel syndrome (IBS) as a behavioural problem has tended to downplay the role of gastrointestinal dysfunction. Contrary to predictions based on the traditional philosophy, a recent study has shown that IBS patients have increased pain tolerance compared to he...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/715236 |
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| Summary: | The traditional perspective of irritable bowel syndrome (IBS) as a
behavioural problem has tended to downplay the role of gastrointestinal dysfunction.
Contrary to predictions based on the traditional philosophy, a recent
study has shown that IBS patients have increased pain tolerance compared to
healthy subjects. This profile of pain tolerance is similar to that seen in chronic
organic disease of the gut (eg, Crohn's disease), raising the possibility that IBS
patients may experience pain resulting from gastrointestinal dysfunction. The
recent finding of increased airway responsiveness to inhaled methacholine in
certain IBS patients provides an objective and quantifiable measurement of tissue
dysfunction in that syndrome, and focuses attention on possible mechanisms
underlying the altered responsiveness of hollow organs in patients with IBS; these
mechanisms are discussed. |
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| ISSN: | 0835-7900 |