Frequency of Y chromosome Microdeletions in Turkish Infertile Men: Single Center Experience
Objective: Infertility is defined as the failure to achieve a clinical pregnancy after twelve months of regular unprotected sexual intercourse. Both genetic and environmental factors affect infertility. The aim of the study is to establish the frequency of the Y chromosome microdeletions in Turkish...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2022-12-01
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| Series: | Genel Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2712996 |
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| author | Aysel Kalaycı Yiğin Mehmet Seven Deniz Ağırbaşlı Gizem Erdoğan Erdur |
| author_facet | Aysel Kalaycı Yiğin Mehmet Seven Deniz Ağırbaşlı Gizem Erdoğan Erdur |
| author_sort | Aysel Kalaycı Yiğin |
| collection | DOAJ |
| description | Objective: Infertility is defined as the failure to achieve a clinical pregnancy after twelve months of regular unprotected sexual intercourse. Both genetic and environmental factors affect infertility. The aim of the study is to establish the frequency of the Y chromosome microdeletions in Turkish infertile men who were referred to our center (2016-2020) with severe oligozoospermia and azoospermia.
Methods: A retrospective chart review study on patients who referred to our center between 2016-2020 due to infertility were included in the study. We evaluated microdeletions of the Y-chromosome STS markers AZFa, AZFb and AZFc, ZFX/ZFY, and terminal sY160 regions. Y-chromosome STS markers were evaluated by DNA fragment analysis.
Results: The chart review indicated that a total of 319 men applied to our genetic diagnosis center between 2016 and 2020 due to infertility (mean age 32 ±7). Among the 319 infertile men, we determined 21 cases with Y chromosome microdeletions (6.89%), with the most common AZFc deletion (n=11, 52.3%) which is consistent with literature.
Conclusion: Y-microdeletions are among the most common genetic causes of male infertility. In azoospermic and oligospermic patients, cytogenetic tests, Y-chromosome microdeletions and NGS panel screening tests can give effective information before the use of assisted reproductive techniques. |
| format | Article |
| id | doaj-art-d377034552d14f1abe5c697a9875e421 |
| institution | Kabale University |
| issn | 2602-3741 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj-art-d377034552d14f1abe5c697a9875e4212025-01-02T23:43:04ZengSelcuk University PressGenel Tıp Dergisi2602-37412022-12-0132673773910.54005/geneltip.1190217154Frequency of Y chromosome Microdeletions in Turkish Infertile Men: Single Center ExperienceAysel Kalaycı Yiğin0Mehmet Seven1Deniz Ağırbaşlı2Gizem Erdoğan Erdur3ISTANBUL UNIVERSITY-CERRAHPASA, CERRAHPAŞA SCHOOL OF MEDICINEISTANBUL UNIVERSITY-CERRAHPASA, CERRAHPAŞA SCHOOL OF MEDICINEISTANBUL UNIVERSITY-CERRAHPASA, CERRAHPAŞA SCHOOL OF MEDICINEISTANBUL UNIVERSITY-CERRAHPASA, CERRAHPAŞA SCHOOL OF MEDICINEObjective: Infertility is defined as the failure to achieve a clinical pregnancy after twelve months of regular unprotected sexual intercourse. Both genetic and environmental factors affect infertility. The aim of the study is to establish the frequency of the Y chromosome microdeletions in Turkish infertile men who were referred to our center (2016-2020) with severe oligozoospermia and azoospermia. Methods: A retrospective chart review study on patients who referred to our center between 2016-2020 due to infertility were included in the study. We evaluated microdeletions of the Y-chromosome STS markers AZFa, AZFb and AZFc, ZFX/ZFY, and terminal sY160 regions. Y-chromosome STS markers were evaluated by DNA fragment analysis. Results: The chart review indicated that a total of 319 men applied to our genetic diagnosis center between 2016 and 2020 due to infertility (mean age 32 ±7). Among the 319 infertile men, we determined 21 cases with Y chromosome microdeletions (6.89%), with the most common AZFc deletion (n=11, 52.3%) which is consistent with literature. Conclusion: Y-microdeletions are among the most common genetic causes of male infertility. In azoospermic and oligospermic patients, cytogenetic tests, Y-chromosome microdeletions and NGS panel screening tests can give effective information before the use of assisted reproductive techniques.https://dergipark.org.tr/tr/download/article-file/2712996infertilityy chromosomemicrodeletionazoospermiainfertilitey-kromozomazoospermiamikrodelesyon |
| spellingShingle | Aysel Kalaycı Yiğin Mehmet Seven Deniz Ağırbaşlı Gizem Erdoğan Erdur Frequency of Y chromosome Microdeletions in Turkish Infertile Men: Single Center Experience Genel Tıp Dergisi infertility y chromosome microdeletion azoospermia infertilite y-kromozom azoospermia mikrodelesyon |
| title | Frequency of Y chromosome Microdeletions in Turkish Infertile Men: Single Center Experience |
| title_full | Frequency of Y chromosome Microdeletions in Turkish Infertile Men: Single Center Experience |
| title_fullStr | Frequency of Y chromosome Microdeletions in Turkish Infertile Men: Single Center Experience |
| title_full_unstemmed | Frequency of Y chromosome Microdeletions in Turkish Infertile Men: Single Center Experience |
| title_short | Frequency of Y chromosome Microdeletions in Turkish Infertile Men: Single Center Experience |
| title_sort | frequency of y chromosome microdeletions in turkish infertile men single center experience |
| topic | infertility y chromosome microdeletion azoospermia infertilite y-kromozom azoospermia mikrodelesyon |
| url | https://dergipark.org.tr/tr/download/article-file/2712996 |
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