Efficacy of aflibercept in patients with neovascular age-related macular degeneration when combined with cataract surgery
Purpose: to study the effectiveness of aflibercept in the treatment of neovascular age-related macular degeneration (AMD) combined with cataract phacoemulsification with intraocular lens (IOL) implantation. Material and methods. A short-term, prospective, controlled, non randomized comparative study...
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Real Time Ltd
2018-10-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/119 |
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| author | A. A. Kuznetsov E. V. Tur A. V. Zurochka V. S. Rykun |
| author_facet | A. A. Kuznetsov E. V. Tur A. V. Zurochka V. S. Rykun |
| author_sort | A. A. Kuznetsov |
| collection | DOAJ |
| description | Purpose: to study the effectiveness of aflibercept in the treatment of neovascular age-related macular degeneration (AMD) combined with cataract phacoemulsification with intraocular lens (IOL) implantation. Material and methods. A short-term, prospective, controlled, non randomized comparative study of the effect of aflibercept on the changes of visual acuity, the morphometric parameters of the macular area of the retina, and the immunological ophthalmologic status was carried out on 31 patients with neovascular AMD within 1 month after medication usage start. Results. Intravitreal injection of aflibercept leads to a decrease in diffuse retinal edema in the macular area, the size of neuro- and pigment epithelium detachment, and the size of choroidal neovascularization, which in a number of cases was accompanied by an increase in visual acuity, especially with a simultaneous surgical treatment of cataract. Phacoemulsification with IOL implantation neither deteriorates the course of AMD nor affects aflibercept efficacy. The determination of the immune status of tears in the early period after intravitreal administration of aflibercept could not be seen as a relevant method of drug effectiveness assessment. Conclusion. Intravitreal administration of vascular endothelial growth factor inhibitor, aflibercept (Eilea, Bayer Pharma AG, Germany) is an effective method of neovascular AMD treatment including the cases of simultaneous cataract surgery. For citations: Kuznetsov A.A., Tur E.V., Zurochka A.V., Rykun V.S. Efficacy of aflibercept in patients with neovascular age-related macular degeneration when combined with cataract surgery Russian ophthalmological journal. 2017; 10 (4): 20-8. doi: 10.21516/2072-0076-2017-10-4-20-28 (in Russian). |
| format | Article |
| id | doaj-art-d357f8ee4b4e4db2acd0a4ed7e971e02 |
| institution | Kabale University |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| publishDate | 2018-10-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj-art-d357f8ee4b4e4db2acd0a4ed7e971e022025-08-20T03:39:45ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602018-10-01104202810.21516/2072-0076-2017-10-4-20-28119Efficacy of aflibercept in patients with neovascular age-related macular degeneration when combined with cataract surgeryA. A. Kuznetsov0E. V. Tur1A. V. Zurochka2V. S. Rykun3Chelyabinsk Regional Clinical HospitalSouth-Ural State Medical UniversityInstitute of Immunology and Physiology, Ural Branch of the Russian Academy of SciencesSouth-Ural State Medical UniversityPurpose: to study the effectiveness of aflibercept in the treatment of neovascular age-related macular degeneration (AMD) combined with cataract phacoemulsification with intraocular lens (IOL) implantation. Material and methods. A short-term, prospective, controlled, non randomized comparative study of the effect of aflibercept on the changes of visual acuity, the morphometric parameters of the macular area of the retina, and the immunological ophthalmologic status was carried out on 31 patients with neovascular AMD within 1 month after medication usage start. Results. Intravitreal injection of aflibercept leads to a decrease in diffuse retinal edema in the macular area, the size of neuro- and pigment epithelium detachment, and the size of choroidal neovascularization, which in a number of cases was accompanied by an increase in visual acuity, especially with a simultaneous surgical treatment of cataract. Phacoemulsification with IOL implantation neither deteriorates the course of AMD nor affects aflibercept efficacy. The determination of the immune status of tears in the early period after intravitreal administration of aflibercept could not be seen as a relevant method of drug effectiveness assessment. Conclusion. Intravitreal administration of vascular endothelial growth factor inhibitor, aflibercept (Eilea, Bayer Pharma AG, Germany) is an effective method of neovascular AMD treatment including the cases of simultaneous cataract surgery. For citations: Kuznetsov A.A., Tur E.V., Zurochka A.V., Rykun V.S. Efficacy of aflibercept in patients with neovascular age-related macular degeneration when combined with cataract surgery Russian ophthalmological journal. 2017; 10 (4): 20-8. doi: 10.21516/2072-0076-2017-10-4-20-28 (in Russian).https://roj.igb.ru/jour/article/view/119афлиберцептвозрастная макулярная дегенерацияанти-vegf терапиямультиплексный анализafliberceptage-related macular degenerationanti-vegf therapymultiplex analysis |
| spellingShingle | A. A. Kuznetsov E. V. Tur A. V. Zurochka V. S. Rykun Efficacy of aflibercept in patients with neovascular age-related macular degeneration when combined with cataract surgery Российский офтальмологический журнал афлиберцепт возрастная макулярная дегенерация анти-vegf терапия мультиплексный анализ aflibercept age-related macular degeneration anti-vegf therapy multiplex analysis |
| title | Efficacy of aflibercept in patients with neovascular age-related macular degeneration when combined with cataract surgery |
| title_full | Efficacy of aflibercept in patients with neovascular age-related macular degeneration when combined with cataract surgery |
| title_fullStr | Efficacy of aflibercept in patients with neovascular age-related macular degeneration when combined with cataract surgery |
| title_full_unstemmed | Efficacy of aflibercept in patients with neovascular age-related macular degeneration when combined with cataract surgery |
| title_short | Efficacy of aflibercept in patients with neovascular age-related macular degeneration when combined with cataract surgery |
| title_sort | efficacy of aflibercept in patients with neovascular age related macular degeneration when combined with cataract surgery |
| topic | афлиберцепт возрастная макулярная дегенерация анти-vegf терапия мультиплексный анализ aflibercept age-related macular degeneration anti-vegf therapy multiplex analysis |
| url | https://roj.igb.ru/jour/article/view/119 |
| work_keys_str_mv | AT aakuznetsov efficacyofafliberceptinpatientswithneovascularagerelatedmaculardegenerationwhencombinedwithcataractsurgery AT evtur efficacyofafliberceptinpatientswithneovascularagerelatedmaculardegenerationwhencombinedwithcataractsurgery AT avzurochka efficacyofafliberceptinpatientswithneovascularagerelatedmaculardegenerationwhencombinedwithcataractsurgery AT vsrykun efficacyofafliberceptinpatientswithneovascularagerelatedmaculardegenerationwhencombinedwithcataractsurgery |