Anesthesia Management of Cold Agglutinin Disease in a Pregnant Patient: A Case Report
ABSTRACT Cold agglutinin disease (CAD), a rare autoimmune hemolytic anemia (AIHA), is characterized by hemolysis triggered by activation of the classical complement pathway. AIHA is estimated to affect one in 100,000 people in the general population; however, its incidence in pregnant women is uncle...
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Wiley
2024-12-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.9645 |
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| author | Jibran Ikram Chase Jackson Sabry Ayad |
| author_facet | Jibran Ikram Chase Jackson Sabry Ayad |
| author_sort | Jibran Ikram |
| collection | DOAJ |
| description | ABSTRACT Cold agglutinin disease (CAD), a rare autoimmune hemolytic anemia (AIHA), is characterized by hemolysis triggered by activation of the classical complement pathway. AIHA is estimated to affect one in 100,000 people in the general population; however, its incidence in pregnant women is unclear due to the scarcity of published studies. Here, we present the case of a 37‐year‐old female (G2P1102) who presented for a repeat Cesarean section. Her peripartum course was complicated by anemia (hemoglobin 7.9 g/dL, hematocrit 29.4%) attributed to cold agglutinin disease, necessitating the transfusion of 20 units of blood during this pregnancy. She had been receiving prednisone 10 mg daily for anemia. Cold temperatures can trigger the activation of cold‐reactive antibodies, leading to red blood cells agglutination (clumping together). Preventing hypothermia reduces the likelihood of cold‐induced hemolysis, which is the primary therapeutic strategy for cold agglutinin disease. Anesthetic management for the cesarean section was accomplished via spinal anesthesia, complemented by pain control through bilateral transversus abdominis plane (TAP) blocks. This multidisciplinary approach facilitated effective pain management while considering the patient's underlying condition. |
| format | Article |
| id | doaj-art-d343c6c83d6948529e2457d41b56bde4 |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-d343c6c83d6948529e2457d41b56bde42024-12-26T06:30:42ZengWileyClinical Case Reports2050-09042024-12-011212n/an/a10.1002/ccr3.9645Anesthesia Management of Cold Agglutinin Disease in a Pregnant Patient: A Case ReportJibran Ikram0Chase Jackson1Sabry Ayad2Department of Outcomes Research, Anesthesiology Institute Cleveland Clinic Cleveland Ohio USADepartment of Outcomes Research, Anesthesiology Institute Cleveland Clinic Cleveland Ohio USADepartment of Outcomes Research, Anesthesiology Institute Cleveland Clinic Cleveland Ohio USAABSTRACT Cold agglutinin disease (CAD), a rare autoimmune hemolytic anemia (AIHA), is characterized by hemolysis triggered by activation of the classical complement pathway. AIHA is estimated to affect one in 100,000 people in the general population; however, its incidence in pregnant women is unclear due to the scarcity of published studies. Here, we present the case of a 37‐year‐old female (G2P1102) who presented for a repeat Cesarean section. Her peripartum course was complicated by anemia (hemoglobin 7.9 g/dL, hematocrit 29.4%) attributed to cold agglutinin disease, necessitating the transfusion of 20 units of blood during this pregnancy. She had been receiving prednisone 10 mg daily for anemia. Cold temperatures can trigger the activation of cold‐reactive antibodies, leading to red blood cells agglutination (clumping together). Preventing hypothermia reduces the likelihood of cold‐induced hemolysis, which is the primary therapeutic strategy for cold agglutinin disease. Anesthetic management for the cesarean section was accomplished via spinal anesthesia, complemented by pain control through bilateral transversus abdominis plane (TAP) blocks. This multidisciplinary approach facilitated effective pain management while considering the patient's underlying condition.https://doi.org/10.1002/ccr3.9645autoimmune hemolytic anemiacold agglutinin diseasemultidisciplinary approachperipartum anemiapregnancy management |
| spellingShingle | Jibran Ikram Chase Jackson Sabry Ayad Anesthesia Management of Cold Agglutinin Disease in a Pregnant Patient: A Case Report Clinical Case Reports autoimmune hemolytic anemia cold agglutinin disease multidisciplinary approach peripartum anemia pregnancy management |
| title | Anesthesia Management of Cold Agglutinin Disease in a Pregnant Patient: A Case Report |
| title_full | Anesthesia Management of Cold Agglutinin Disease in a Pregnant Patient: A Case Report |
| title_fullStr | Anesthesia Management of Cold Agglutinin Disease in a Pregnant Patient: A Case Report |
| title_full_unstemmed | Anesthesia Management of Cold Agglutinin Disease in a Pregnant Patient: A Case Report |
| title_short | Anesthesia Management of Cold Agglutinin Disease in a Pregnant Patient: A Case Report |
| title_sort | anesthesia management of cold agglutinin disease in a pregnant patient a case report |
| topic | autoimmune hemolytic anemia cold agglutinin disease multidisciplinary approach peripartum anemia pregnancy management |
| url | https://doi.org/10.1002/ccr3.9645 |
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