Pathology of single dose cadmium toxicity and investigations of protective effect of simultaneous chlorpromazine administrations in rats
<b>Aim:</b> This study was carried out to determine pathology of cadmium toxicity and protective effects of chlorpromazine in rats, simultaneously.<p> <b>Materials and Methods:</b> Totally 64 Sprague-Dawley rats were divided into four equal groups. Isotonic saline (C),...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=546 |
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| Summary: | <b>Aim:</b> This study was carried out to determine pathology of
cadmium toxicity and protective effects of chlorpromazine
in rats, simultaneously.<p>
<b>Materials and Methods:</b> Totally 64 Sprague-Dawley rats
were divided into four equal groups. Isotonic saline (C), cadmium
chloride (CD), chlorpromazine (CPZ), cadmium plus
chlorpromazine (CDCPZ) were injected as a single dose,
respectively. Body weight changes, relative organs weights,
hematologic and biochemical values were determined. Macroscopical,
histopathological and immunohistochemical
findings were also examined.<p>
<b>Results:</b> In the CD and CDCPZ groups, not only the body
weights decreased but also significant lesions were seen in
the testes and epididymis. Relative testes and epididymis
weights decreased and atrophy was seen in these organs.
In addition, disseminate and intensity necrosis with vessel
lesions in the testes was observed. Corresponding to these
changes significant decreases in serum testosterone levels
were also observed and the spermatic granulomas were
seen in the epididymis. Although liver and kidneys were
slightly affected, it was observed that damage in these organs
would not cause a significant change in the serum biochemical
values.<p>
<b>Conclusion:</b> Chlorpromazine injected simultaneously with
cadmium had neither protective nor curative effects against
cadmium toxicity. It was thought that studies concerning
prevention or treatment of cadmium toxication should be
planned for longer time periods to obtain better outcomes. |
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| ISSN: | 1309-6958 2146-1953 |