MIL-101 (Cr): synthesis and simultaneous electrochemical determination of uric acid and theophylline using MIL-101 (Cr) modified electrode
This paper uses hydrothermal processes to synthesize metal–organic frameworks in the MIL (Materials Institute Lavoisier) series. Our research revealed that MIL-101 was formed at the early synthetic stage, approximately eight hours, followed by the formation of MIL-88B with further prolongation of th...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2025-01-01
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| Series: | Materials Research Express |
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| Online Access: | https://doi.org/10.1088/2053-1591/adfad2 |
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| author | Nguyen Ngoc Nghia Nguyen Quang Man Hoa Thi Le Nguyen Duc Vu Quyen Ho Van Minh Hai Nguyen Chi Bao Son Van Thanh Le Trinh Ngoc Dat Le Thi Hong Phong Vo Thi Khanh Ly Nguyen Dinh Luyen Dinh Quang Khieu |
| author_facet | Nguyen Ngoc Nghia Nguyen Quang Man Hoa Thi Le Nguyen Duc Vu Quyen Ho Van Minh Hai Nguyen Chi Bao Son Van Thanh Le Trinh Ngoc Dat Le Thi Hong Phong Vo Thi Khanh Ly Nguyen Dinh Luyen Dinh Quang Khieu |
| author_sort | Nguyen Ngoc Nghia |
| collection | DOAJ |
| description | This paper uses hydrothermal processes to synthesize metal–organic frameworks in the MIL (Materials Institute Lavoisier) series. Our research revealed that MIL-101 was formed at the early synthetic stage, approximately eight hours, followed by the formation of MIL-88B with further prolongation of the hydrothermal time. The morphology of the octahedral shape for MIL-101 transformed into the rod-like shape of MIL-88B, accompanied by a decrease in the surface area. The electrode modified by MIL-101 exhibited electrochemical activity towards uric acid and theophylline better than that modified by MIL-88B. We also developed a glassy carbon electrode (GCE) modified by MIL-101 for simultaneous uric acid and theophylline detection. Electrochemical sensing features were investigated using electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV). The calibration curves for uric acid and theophylline were obtained in the 0.20–1.69 μM range. The detection limits (3 σ ) were 0.12 μM and 0.13 μM for uric acid and theophylline, respectively. Notably, using a standard addition method, the present approach was used to determine URI and THE in urine samples, achieving exceptional recoveries. The proposed electrochemical sensor also revealed good reproducibility, repeatability, and long-term stability. |
| format | Article |
| id | doaj-art-d32bde0b624c4bb5b1a0e039c0a8072c |
| institution | Kabale University |
| issn | 2053-1591 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj-art-d32bde0b624c4bb5b1a0e039c0a8072c2025-08-20T12:00:51ZengIOP PublishingMaterials Research Express2053-15912025-01-0112808500410.1088/2053-1591/adfad2MIL-101 (Cr): synthesis and simultaneous electrochemical determination of uric acid and theophylline using MIL-101 (Cr) modified electrodeNguyen Ngoc Nghia0https://orcid.org/0009-0009-9166-7815Nguyen Quang Man1https://orcid.org/0000-0001-6511-1236Hoa Thi Le2https://orcid.org/0000-0002-1359-187XNguyen Duc Vu Quyen3https://orcid.org/0000-0002-1949-5379Ho Van Minh Hai4https://orcid.org/0000-0001-5464-4782Nguyen Chi Bao5https://orcid.org/0000-0002-9239-3774Son Van Thanh Le6https://orcid.org/0000-0002-2061-6983Trinh Ngoc Dat7Le Thi Hong Phong8https://orcid.org/0000-0001-8825-6243Vo Thi Khanh Ly9https://orcid.org/0009-0005-0854-3290Nguyen Dinh Luyen10https://orcid.org/0009-0004-3926-9282Dinh Quang Khieu11https://orcid.org/0000-0003-3473-6377Hue University , University of Sciences, Hue City, 530000, Vietnam; Department of Education and Training, Hue City, 530000, VietnamHue University , University of Medicine and Pharmacy, Hue City 530000, VietnamHue University , University of Sciences, Hue City, 530000, VietnamHue University , University of Sciences, Hue City, 530000, VietnamHue University , University of Sciences, Hue City, 530000, VietnamHue University , Hue City, 530000, VietnamThe University of Danang , University of Science and Education, Danang City, 550000, VietnamThe University of Danang , University of Science and Education, Danang City, 550000, VietnamInstitute of Materials Science, Vietnam Academy of Science and Technology - 18 Hoang Quoc Viet, Cau Giay, Ha Noi City, VietnamFaculty of Pharmacy, Hue Medical College , Hue City, 530000, VietnamHue University , University of Education, Hue City, 530000, VietnamHue University , University of Sciences, Hue City, 530000, VietnamThis paper uses hydrothermal processes to synthesize metal–organic frameworks in the MIL (Materials Institute Lavoisier) series. Our research revealed that MIL-101 was formed at the early synthetic stage, approximately eight hours, followed by the formation of MIL-88B with further prolongation of the hydrothermal time. The morphology of the octahedral shape for MIL-101 transformed into the rod-like shape of MIL-88B, accompanied by a decrease in the surface area. The electrode modified by MIL-101 exhibited electrochemical activity towards uric acid and theophylline better than that modified by MIL-88B. We also developed a glassy carbon electrode (GCE) modified by MIL-101 for simultaneous uric acid and theophylline detection. Electrochemical sensing features were investigated using electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and differential pulse voltammetry (DPV). The calibration curves for uric acid and theophylline were obtained in the 0.20–1.69 μM range. The detection limits (3 σ ) were 0.12 μM and 0.13 μM for uric acid and theophylline, respectively. Notably, using a standard addition method, the present approach was used to determine URI and THE in urine samples, achieving exceptional recoveries. The proposed electrochemical sensor also revealed good reproducibility, repeatability, and long-term stability.https://doi.org/10.1088/2053-1591/adfad2uric acidtheophyllineMIL-88BMIL-101 |
| spellingShingle | Nguyen Ngoc Nghia Nguyen Quang Man Hoa Thi Le Nguyen Duc Vu Quyen Ho Van Minh Hai Nguyen Chi Bao Son Van Thanh Le Trinh Ngoc Dat Le Thi Hong Phong Vo Thi Khanh Ly Nguyen Dinh Luyen Dinh Quang Khieu MIL-101 (Cr): synthesis and simultaneous electrochemical determination of uric acid and theophylline using MIL-101 (Cr) modified electrode Materials Research Express uric acid theophylline MIL-88B MIL-101 |
| title | MIL-101 (Cr): synthesis and simultaneous electrochemical determination of uric acid and theophylline using MIL-101 (Cr) modified electrode |
| title_full | MIL-101 (Cr): synthesis and simultaneous electrochemical determination of uric acid and theophylline using MIL-101 (Cr) modified electrode |
| title_fullStr | MIL-101 (Cr): synthesis and simultaneous electrochemical determination of uric acid and theophylline using MIL-101 (Cr) modified electrode |
| title_full_unstemmed | MIL-101 (Cr): synthesis and simultaneous electrochemical determination of uric acid and theophylline using MIL-101 (Cr) modified electrode |
| title_short | MIL-101 (Cr): synthesis and simultaneous electrochemical determination of uric acid and theophylline using MIL-101 (Cr) modified electrode |
| title_sort | mil 101 cr synthesis and simultaneous electrochemical determination of uric acid and theophylline using mil 101 cr modified electrode |
| topic | uric acid theophylline MIL-88B MIL-101 |
| url | https://doi.org/10.1088/2053-1591/adfad2 |
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