arterioscope.sim: Enabling Simulations of Blood Flow and Its Impact on Bioimpedance Signals
Objectives: Early detection of cardiovascular diseases and their pre-existing conditions, arteriosclerosis and atherosclerosis, is crucial to increasing a patient’s chance of survival. While imaging technologies and invasive procedures provide a reliable diagnosis, they carry high costs and risks fo...
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MDPI AG
2024-12-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/11/12/1273 |
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| author | Thomas Krispel Vahid Badeli Alireza Jafarinia Alice Reinbacher-Köstinger Christian Tronstad Sascha Ranftl Ørjan Grottem Martinsen Håvard Kalvoy Jonny Hisdal Manfred Kaltenbacher Thomas Hochrainer |
| author_facet | Thomas Krispel Vahid Badeli Alireza Jafarinia Alice Reinbacher-Köstinger Christian Tronstad Sascha Ranftl Ørjan Grottem Martinsen Håvard Kalvoy Jonny Hisdal Manfred Kaltenbacher Thomas Hochrainer |
| author_sort | Thomas Krispel |
| collection | DOAJ |
| description | Objectives: Early detection of cardiovascular diseases and their pre-existing conditions, arteriosclerosis and atherosclerosis, is crucial to increasing a patient’s chance of survival. While imaging technologies and invasive procedures provide a reliable diagnosis, they carry high costs and risks for patients. This study aims to explore impedance plethysmography (IPG) as a non-invasive and affordable alternative for diagnosis. Methods: To address the current lack of large-scale, high-quality impedance data, we introduce arterioscope.sim, a simulation platform that models arterial blood flow and computes the electrical conductivity of blood. The platform simulates bioimpedance measurements on specific body segments using patient-specific parameters. The study investigates how introducing arterial diseases into the simulation affects the bioimpedance signals. Results: The simulation results demonstrate that introducing atherosclerosis and arteriosclerosis leads to significant changes in the computed signals compared to simulations of healthy arteries. Furthermore, simulation of a patient-specific healthy artery strongly correlates with measured signals from a healthy volunteer. Conclusions and significance: arterioscope.sim effectively simulates bioimpedance signals in healthy and diseased arteries and highlights the potential of using these signals for early diagnosis of arterial diseases, offering a non-invasive and cost-effective alternative to traditional diagnostic methods. |
| format | Article |
| id | doaj-art-d31d0ab1ceec4b55878ca5fd31be6d1d |
| institution | Kabale University |
| issn | 2306-5354 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-d31d0ab1ceec4b55878ca5fd31be6d1d2024-12-27T14:11:42ZengMDPI AGBioengineering2306-53542024-12-011112127310.3390/bioengineering11121273arterioscope.sim: Enabling Simulations of Blood Flow and Its Impact on Bioimpedance SignalsThomas Krispel0Vahid Badeli1Alireza Jafarinia2Alice Reinbacher-Köstinger3Christian Tronstad4Sascha Ranftl5Ørjan Grottem Martinsen6Håvard Kalvoy7Jonny Hisdal8Manfred Kaltenbacher9Thomas Hochrainer10Institute for Fundamentals and Theory in Electrical Engineering, Graz University of Technology, 8010 Graz, AustriaInstitute for Fundamentals and Theory in Electrical Engineering, Graz University of Technology, 8010 Graz, AustriaInstitute of Strength of Materials, Graz University of Technology, 8010 Graz, AustriaInstitute for Fundamentals and Theory in Electrical Engineering, Graz University of Technology, 8010 Graz, AustriaDepartment of Clinical and Biomedical Engineering, Oslo University Hospital, 0372 Oslo, NorwayInstitute of Theoretical and Computational Physics, Graz University of Technology, 8010 Graz, AustriaDepartment of Clinical and Biomedical Engineering, Oslo University Hospital, 0372 Oslo, NorwayDepartment of Clinical and Biomedical Engineering, Oslo University Hospital, 0372 Oslo, NorwayDepartment of Vascular Diseases at Oslo University Hospital, 0586 Oslo, NorwayInstitute for Fundamentals and Theory in Electrical Engineering, Graz University of Technology, 8010 Graz, AustriaInstitute of Strength of Materials, Graz University of Technology, 8010 Graz, AustriaObjectives: Early detection of cardiovascular diseases and their pre-existing conditions, arteriosclerosis and atherosclerosis, is crucial to increasing a patient’s chance of survival. While imaging technologies and invasive procedures provide a reliable diagnosis, they carry high costs and risks for patients. This study aims to explore impedance plethysmography (IPG) as a non-invasive and affordable alternative for diagnosis. Methods: To address the current lack of large-scale, high-quality impedance data, we introduce arterioscope.sim, a simulation platform that models arterial blood flow and computes the electrical conductivity of blood. The platform simulates bioimpedance measurements on specific body segments using patient-specific parameters. The study investigates how introducing arterial diseases into the simulation affects the bioimpedance signals. Results: The simulation results demonstrate that introducing atherosclerosis and arteriosclerosis leads to significant changes in the computed signals compared to simulations of healthy arteries. Furthermore, simulation of a patient-specific healthy artery strongly correlates with measured signals from a healthy volunteer. Conclusions and significance: arterioscope.sim effectively simulates bioimpedance signals in healthy and diseased arteries and highlights the potential of using these signals for early diagnosis of arterial diseases, offering a non-invasive and cost-effective alternative to traditional diagnostic methods.https://www.mdpi.com/2306-5354/11/12/1273bioimpedanceblood flowcardiovascular diseaseimpedance plethysmographynumerical simulation |
| spellingShingle | Thomas Krispel Vahid Badeli Alireza Jafarinia Alice Reinbacher-Köstinger Christian Tronstad Sascha Ranftl Ørjan Grottem Martinsen Håvard Kalvoy Jonny Hisdal Manfred Kaltenbacher Thomas Hochrainer arterioscope.sim: Enabling Simulations of Blood Flow and Its Impact on Bioimpedance Signals Bioengineering bioimpedance blood flow cardiovascular disease impedance plethysmography numerical simulation |
| title | arterioscope.sim: Enabling Simulations of Blood Flow and Its Impact on Bioimpedance Signals |
| title_full | arterioscope.sim: Enabling Simulations of Blood Flow and Its Impact on Bioimpedance Signals |
| title_fullStr | arterioscope.sim: Enabling Simulations of Blood Flow and Its Impact on Bioimpedance Signals |
| title_full_unstemmed | arterioscope.sim: Enabling Simulations of Blood Flow and Its Impact on Bioimpedance Signals |
| title_short | arterioscope.sim: Enabling Simulations of Blood Flow and Its Impact on Bioimpedance Signals |
| title_sort | arterioscope sim enabling simulations of blood flow and its impact on bioimpedance signals |
| topic | bioimpedance blood flow cardiovascular disease impedance plethysmography numerical simulation |
| url | https://www.mdpi.com/2306-5354/11/12/1273 |
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