LEPTIN AND METABOLISM IN PREGNANT WOMEN WITH REDUCED BODY MASS INDEX
Aim. To investigate the association of leptin serum level and metabolic features in pregnant women with a reduced body mass index (BMI). Materials and Methods. I recruited 100 pregnant women with either reduced or normal BMI (50 women per group) and then evaluated features of their protein, lipid,...
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| Format: | Article |
| Language: | Russian |
| Published: |
Kemerovo State Medical University
2017-09-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/56 |
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| Summary: | Aim. To investigate the association of leptin serum level and metabolic features in pregnant women with a reduced body mass index (BMI). Materials and Methods. I recruited 100 pregnant women with either reduced or normal BMI (50 women per group) and then evaluated features of their protein, lipid, and carbohydrate metabolism following measurement of a serum leptin level. Results. Almost all pregnant women with a reduced BMI were diagnosed with protein and albumin deficiency (55.9 ± 0.6 g/L and 53.4 ± 1.3%, respec-tively) while those with a normal BMI had both total protein and albumin serum levels within the reference values (60.9 ± 1.06 g/L and 55.8 ± 1.6%, respectively, р < 0.001). Furthermore, fasting glucose level in women with a reduced BMI was lower compared to those with a normal BMI (4.2 ± 0.07 mmol/L and 4.46 ± 0.13 mmol/L, р < 0.001). Finally, women with a reduced BMI had lower concentrations of total cholesterol (5.8 ± 0.16 mmol/L), triglycerides (2.92 ± 0.12 mmol/L, high-density lipoprotein cholesterol (1.78 ± 0.03 mmol/L), low-density lipoprotein cholesterol (2.25 ± 0.19 mmol/L), and atherogenic index (2.4 ± 0.19) in comparison with those with a normal BMI (6.2 ± 1.1 mmol/L, р = 0.0125; 3.31 ± 0.14 mmol/L, р < 0.001; 1.85 ± 0.15 mmol/L, р = 0,0017; 2.57 ± 0.21 mmol/L, р < 0,001; 2.61 ± 0.20, р < 0.001, respectively). Serum level of leptin in women with a reduced BMI was decreased compared to those with a normal BMI (9.3 ± 1.0 ng/mL and 21.45 ± 2.2 ng/mL, respectively, p < 0.001).Conclusions. Metabolic disturbances are characteristic for pregnant women with a reduced BMI, and serum leptin can be suggested as a specific diagnostic biomarker. |
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| ISSN: | 2500-0764 2542-0941 |