The Clinical Significance of HLA Compatibility Scores in Lung Transplantation
Lung transplantation is a life-saving therapeutic option for many chronic end-stage pulmonary diseases, but long-term survival may be limited by rejection of the transplanted organ. Since HLA disparity between donor and recipient plays a major role in rejection, we performed a single center, retrosp...
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Frontiers Media S.A.
2025-01-01
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| Series: | Transplant International |
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| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13484/full |
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| author | Liesbeth Daniëls Liesbeth Daniëls Hanne Beeckmans Andrea Zajacova Pieterjan Kerckhof Saskia Bos Maarten Naesens Bart Vanaudenaerde Frans Claas Frans Claas Robin Vos Robin Vos |
| author_facet | Liesbeth Daniëls Liesbeth Daniëls Hanne Beeckmans Andrea Zajacova Pieterjan Kerckhof Saskia Bos Maarten Naesens Bart Vanaudenaerde Frans Claas Frans Claas Robin Vos Robin Vos |
| author_sort | Liesbeth Daniëls |
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| description | Lung transplantation is a life-saving therapeutic option for many chronic end-stage pulmonary diseases, but long-term survival may be limited by rejection of the transplanted organ. Since HLA disparity between donor and recipient plays a major role in rejection, we performed a single center, retrospective observational cohort analysis in our lung transplant cohort (n = 128) in which we calculated HLA compatibility scores for B-cell epitopes (HLAMatchmaker, HLA-EMMA), T-cell epitopes (PIRCHE-II) and missing self-induced NK cell activation (KIR Ligand Calculator). Adjusted Cox proportional hazards model was used to investigate the association between mismatched scores and time to development of donor-specific antibodies (DSA) post-transplant, time to first biopsy-proven acute rejection episode, freedom from CLAD, graft survival and overall survival. For time to first DSA, HLA-EMMA DQB1 scores and PIRCHE-II DQB1 scores were significantly associated with more rapidly developing anti-HLA-DQ antibodies. HLA-EMMA DQB1 score was significantly associated with worse survival. KIR ligand Host-versus-Graft (HvG) mismatches was significantly associated with worse graft survival (CLAD or death) and shorter time to first biopsy-proven rejection when 2 mismatches were present. We demonstrated that HLA-DQB1 compatibility scores and KIR ligand HvG 2 mismatches may allow for identification of recipients at risk of poor long-term outcomes after lung transplantation. |
| format | Article |
| id | doaj-art-d2e556774f1e410782e54fe4a943d1e9 |
| institution | Kabale University |
| issn | 1432-2277 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Transplant International |
| spelling | doaj-art-d2e556774f1e410782e54fe4a943d1e92025-01-03T04:12:38ZengFrontiers Media S.A.Transplant International1432-22772025-01-013710.3389/ti.2024.1348413484The Clinical Significance of HLA Compatibility Scores in Lung TransplantationLiesbeth Daniëls0Liesbeth Daniëls1Hanne Beeckmans2Andrea Zajacova3Pieterjan Kerckhof4Saskia Bos5Maarten Naesens6Bart Vanaudenaerde7Frans Claas8Frans Claas9Robin Vos10Robin Vos11Histocompatibility Laboratory (HLA), Clinical Biology, CHU UCL Namur Site Godinne, Namur, BelgiumFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Chronic Diseases, Metabolism and Ageing, Laboratory for Respiratory Diseases and Thoracic Surgery, Faculty of Medicine, KU Leuven, Leuven, BelgiumDepartment of Chronic Diseases, Metabolism and Ageing, Laboratory for Respiratory Diseases and Thoracic Surgery, Faculty of Medicine, KU Leuven, Leuven, BelgiumDepartment of Chronic Diseases, Metabolism and Ageing, Laboratory for Respiratory Diseases and Thoracic Surgery, Faculty of Medicine, KU Leuven, Leuven, BelgiumDepartment of Respiratory Diseases, University Hospitals Leuven, Leuven, Brussels, BelgiumDepartment of Microbiology, Immunology and Transplantation, Faculty of Medicine, KU Leuven, Leuven, BelgiumDepartment of Chronic Diseases, Metabolism and Ageing, Laboratory for Respiratory Diseases and Thoracic Surgery, Faculty of Medicine, KU Leuven, Leuven, BelgiumEurotransplant and Eurotransplant Reference Laboratory, Department of Immunology, Leiden University Medical Center (LUMC), Leiden, NetherlandsDepartment of Translational Research in Immunology and Inflammation, University of Antwerp, Antwerp, BelgiumDepartment of Chronic Diseases, Metabolism and Ageing, Laboratory for Respiratory Diseases and Thoracic Surgery, Faculty of Medicine, KU Leuven, Leuven, BelgiumDepartment of Respiratory Diseases, University Hospitals Leuven, Leuven, Brussels, BelgiumLung transplantation is a life-saving therapeutic option for many chronic end-stage pulmonary diseases, but long-term survival may be limited by rejection of the transplanted organ. Since HLA disparity between donor and recipient plays a major role in rejection, we performed a single center, retrospective observational cohort analysis in our lung transplant cohort (n = 128) in which we calculated HLA compatibility scores for B-cell epitopes (HLAMatchmaker, HLA-EMMA), T-cell epitopes (PIRCHE-II) and missing self-induced NK cell activation (KIR Ligand Calculator). Adjusted Cox proportional hazards model was used to investigate the association between mismatched scores and time to development of donor-specific antibodies (DSA) post-transplant, time to first biopsy-proven acute rejection episode, freedom from CLAD, graft survival and overall survival. For time to first DSA, HLA-EMMA DQB1 scores and PIRCHE-II DQB1 scores were significantly associated with more rapidly developing anti-HLA-DQ antibodies. HLA-EMMA DQB1 score was significantly associated with worse survival. KIR ligand Host-versus-Graft (HvG) mismatches was significantly associated with worse graft survival (CLAD or death) and shorter time to first biopsy-proven rejection when 2 mismatches were present. We demonstrated that HLA-DQB1 compatibility scores and KIR ligand HvG 2 mismatches may allow for identification of recipients at risk of poor long-term outcomes after lung transplantation.https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13484/fulllung transplantationHLAMatchmakerHLA-EMMAPIRCHE-IIKIR ligand calculator |
| spellingShingle | Liesbeth Daniëls Liesbeth Daniëls Hanne Beeckmans Andrea Zajacova Pieterjan Kerckhof Saskia Bos Maarten Naesens Bart Vanaudenaerde Frans Claas Frans Claas Robin Vos Robin Vos The Clinical Significance of HLA Compatibility Scores in Lung Transplantation Transplant International lung transplantation HLAMatchmaker HLA-EMMA PIRCHE-II KIR ligand calculator |
| title | The Clinical Significance of HLA Compatibility Scores in Lung Transplantation |
| title_full | The Clinical Significance of HLA Compatibility Scores in Lung Transplantation |
| title_fullStr | The Clinical Significance of HLA Compatibility Scores in Lung Transplantation |
| title_full_unstemmed | The Clinical Significance of HLA Compatibility Scores in Lung Transplantation |
| title_short | The Clinical Significance of HLA Compatibility Scores in Lung Transplantation |
| title_sort | clinical significance of hla compatibility scores in lung transplantation |
| topic | lung transplantation HLAMatchmaker HLA-EMMA PIRCHE-II KIR ligand calculator |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13484/full |
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