Skin Barrier-Improving and Skin-Soothing Effects of Autophagy-Activating Peptide on Sensitive Skin
Among the complex and diverse triggering and aggravating factors for sensitive skin syndrome, potential defects in skin barrier function are considered one of the most important ones. Previously, we have reported improvements in skin barrier function thanks to autophagy-activating peptide derivative...
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MDPI AG
2024-12-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/11/6/223 |
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| author | Sohee Eun Minhye Lim Juyeon Jung Kayoung Shin Sungwoo Kim Yeonjae Kim Gaewon Nam Sekyoo Jeong Hyunjung Kim |
| author_facet | Sohee Eun Minhye Lim Juyeon Jung Kayoung Shin Sungwoo Kim Yeonjae Kim Gaewon Nam Sekyoo Jeong Hyunjung Kim |
| author_sort | Sohee Eun |
| collection | DOAJ |
| description | Among the complex and diverse triggering and aggravating factors for sensitive skin syndrome, potential defects in skin barrier function are considered one of the most important ones. Previously, we have reported improvements in skin barrier function thanks to autophagy-activating peptide derivatives. Further investigation revealed that the activation of autophagy signaling in skin cells also attenuated inflammatory responses induced by UV irradiation or exposure to pollution. In this study, in vitro and ex vivo human skin explant models were used to evaluate the potential benefits of the autophagy-activating peptide, pentasodium tetracarboxymethyl palmitoyl didpeptide-12 (PTPD-12), on sensitive skin-related parameters. Clinical efficacy testing was also performed to confirm the skin barrier-improving and skin-soothing activities of the autophagy-activating peptide. As a result, significant reductions in inflammatory cytokine (IL-8 and TNF-α) and enzyme activity (PDE4) were observed in the in vitro system. Increased expression of barrier marker proteins by PTPD-12 in UV-irradiated human skin tissue was observed ex vivo. In a clinical study, delayed response to topical capsaicin-induced vascular activation, which represents enhanced epidermal permeability barrier function, was observed after 4 weeks of application of PTPD-12 in healthy volunteers. In another clinical study with sensitive skin carriers identified via a lactic acid stinging test, a significant reduction in trans-epidermal water loss (TEWL) and skin erythema index was observed after 4 weeks of PTPD-12 usage. These results suggest that the activation of autophagy can be a potential treatment regimen for sensitive skin syndrome, specifically in terms of skin barrier function enhancement and skin soothing. |
| format | Article |
| id | doaj-art-d2e194b03d3d4c36834579b86d4aff9e |
| institution | Kabale University |
| issn | 2079-9284 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Cosmetics |
| spelling | doaj-art-d2e194b03d3d4c36834579b86d4aff9e2024-12-27T14:19:25ZengMDPI AGCosmetics2079-92842024-12-0111622310.3390/cosmetics11060223Skin Barrier-Improving and Skin-Soothing Effects of Autophagy-Activating Peptide on Sensitive SkinSohee Eun0Minhye Lim1Juyeon Jung2Kayoung Shin3Sungwoo Kim4Yeonjae Kim5Gaewon Nam6Sekyoo Jeong7Hyunjung Kim8Kolmar Korea. #61, Heolleung-ro 8-gil, Seocho-gu, Seoul 06800, Republic of KoreaKolmar Korea. #61, Heolleung-ro 8-gil, Seocho-gu, Seoul 06800, Republic of KoreaResearch Team, Incospharm Corp., #4 Kukjegwahak-7-ro, Yuseong-gu, Daejeon 43000, Republic of KoreaResearch Team, Incospharm Corp., #4 Kukjegwahak-7-ro, Yuseong-gu, Daejeon 43000, Republic of KoreaResearch Team, Incospharm Corp., #4 Kukjegwahak-7-ro, Yuseong-gu, Daejeon 43000, Republic of KoreaResearch Team, Incospharm Corp., #4 Kukjegwahak-7-ro, Yuseong-gu, Daejeon 43000, Republic of KoreaDepartment of Bio-Cosmetic Science, Seowon University, 377-3, Musimseoro, Seowon-gu, Cheongju 28674, Chungbuk, Republic of KoreaResearch Team, Incospharm Corp., #4 Kukjegwahak-7-ro, Yuseong-gu, Daejeon 43000, Republic of KoreaDepartment of Dermatology, Chungnam National University Sejong Hospital, 20 Bodeum 7-ro, Sejong 30099, Republic of KoreaAmong the complex and diverse triggering and aggravating factors for sensitive skin syndrome, potential defects in skin barrier function are considered one of the most important ones. Previously, we have reported improvements in skin barrier function thanks to autophagy-activating peptide derivatives. Further investigation revealed that the activation of autophagy signaling in skin cells also attenuated inflammatory responses induced by UV irradiation or exposure to pollution. In this study, in vitro and ex vivo human skin explant models were used to evaluate the potential benefits of the autophagy-activating peptide, pentasodium tetracarboxymethyl palmitoyl didpeptide-12 (PTPD-12), on sensitive skin-related parameters. Clinical efficacy testing was also performed to confirm the skin barrier-improving and skin-soothing activities of the autophagy-activating peptide. As a result, significant reductions in inflammatory cytokine (IL-8 and TNF-α) and enzyme activity (PDE4) were observed in the in vitro system. Increased expression of barrier marker proteins by PTPD-12 in UV-irradiated human skin tissue was observed ex vivo. In a clinical study, delayed response to topical capsaicin-induced vascular activation, which represents enhanced epidermal permeability barrier function, was observed after 4 weeks of application of PTPD-12 in healthy volunteers. In another clinical study with sensitive skin carriers identified via a lactic acid stinging test, a significant reduction in trans-epidermal water loss (TEWL) and skin erythema index was observed after 4 weeks of PTPD-12 usage. These results suggest that the activation of autophagy can be a potential treatment regimen for sensitive skin syndrome, specifically in terms of skin barrier function enhancement and skin soothing.https://www.mdpi.com/2079-9284/11/6/223autophagyclinical studyex vivo modelsensitive skinskin barrierskin soothing |
| spellingShingle | Sohee Eun Minhye Lim Juyeon Jung Kayoung Shin Sungwoo Kim Yeonjae Kim Gaewon Nam Sekyoo Jeong Hyunjung Kim Skin Barrier-Improving and Skin-Soothing Effects of Autophagy-Activating Peptide on Sensitive Skin Cosmetics autophagy clinical study ex vivo model sensitive skin skin barrier skin soothing |
| title | Skin Barrier-Improving and Skin-Soothing Effects of Autophagy-Activating Peptide on Sensitive Skin |
| title_full | Skin Barrier-Improving and Skin-Soothing Effects of Autophagy-Activating Peptide on Sensitive Skin |
| title_fullStr | Skin Barrier-Improving and Skin-Soothing Effects of Autophagy-Activating Peptide on Sensitive Skin |
| title_full_unstemmed | Skin Barrier-Improving and Skin-Soothing Effects of Autophagy-Activating Peptide on Sensitive Skin |
| title_short | Skin Barrier-Improving and Skin-Soothing Effects of Autophagy-Activating Peptide on Sensitive Skin |
| title_sort | skin barrier improving and skin soothing effects of autophagy activating peptide on sensitive skin |
| topic | autophagy clinical study ex vivo model sensitive skin skin barrier skin soothing |
| url | https://www.mdpi.com/2079-9284/11/6/223 |
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