Therapeutic potential of bisphosphonates - review of medical indications, mechanism of action, interactions and adverse effects
Introduction: Bisphosphonates are pharmacological agents that inhibit bone resorption by targeting osteoclasts, thereby increasing bone density and reducing fracture risk. Although they were first synthesized in the 19th century, their clinical significance has only been recognized in the last 50 y...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2025-01-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/57219 |
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| author | Agnieszka Mikosińska Mateusz Litwin Jakub Parys Patrycja Kałuziak Aleksandra Witek Martyna Kaźmierczak Stanisław Jesionek Marta Jajczak Maciej Mossakowski |
| author_facet | Agnieszka Mikosińska Mateusz Litwin Jakub Parys Patrycja Kałuziak Aleksandra Witek Martyna Kaźmierczak Stanisław Jesionek Marta Jajczak Maciej Mossakowski |
| author_sort | Agnieszka Mikosińska |
| collection | DOAJ |
| description |
Introduction: Bisphosphonates are pharmacological agents that inhibit bone resorption by targeting osteoclasts, thereby increasing bone density and reducing fracture risk. Although they were first synthesized in the 19th century, their clinical significance has only been recognized in the last 50 years. This study reviews the current understanding of bisphosphonates, their therapeutic advantages in various disorders, and their mechanism of action, potential interactions, and adverse effects.
Aim of the study: The aim of this study is to provide an overview of the current understanding of bisphosphonates and familiarize readers with their mechanisms of action, interactions and adverse effects. It also aims to briefly introduce diseases that may be treated with bisphosphonates and how this class of medications can improve the course of each disorder. This study focuses on their therapeutic potential and associated risks, highlighting the need for further research in this area.
Material and methods: Literature available in the PubMed database was reviewed using the following keywords:
“bisphosphonates”; “bisphosphonates mechanism of action”; “bisphosphonates side effects”; “bisphosphonates interactions”; “bone tissue”; “skeletal system disorders”; “skeletal system”; “menopause”;” osteogenesis imperfecta”; “bone metastasis”
Conclusions: The introduction of bisphosphonates represents a significant advancement in the management of conditions associated with increased bone turnover, offering clinically substantiated benefits that outweigh the associated risks. This review provides healthcare professionals with evidence-based, scientifically validated information on bisphosphonates, while also identifying critical areas for further investigation to optimize their safety and efficacy, ultimately improving patient outcomes and quality of life.
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| format | Article |
| id | doaj-art-d2d3beb8bea64d81aa5cc1e78ff14da2 |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-d2d3beb8bea64d81aa5cc1e78ff14da22025-01-08T08:16:37ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.57219Therapeutic potential of bisphosphonates - review of medical indications, mechanism of action, interactions and adverse effectsAgnieszka Mikosińska0https://orcid.org/0009-0003-0891-9089Mateusz Litwin1https://orcid.org/0009-0006-5131-1863Jakub Parys2https://orcid.org/0009-0009-1955-7865Patrycja Kałuziak3https://orcid.org/0009-0008-0976-1523Aleksandra Witek4https://orcid.org/0009-0002-1214-2199Martyna Kaźmierczak5https://orcid.org/0009-0007-7798-0069Stanisław Jesionek6https://orcid.org/0009-0004-6026-702XMarta Jajczak7https://orcid.org/0009-0009-6000-7769Maciej Mossakowski8https://orcid.org/0009-0008-0423-2083Central Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Lodz University Clinical Hospital No.2 of Medical University of Lodz, ul. Żeromskiego 113, 90-549 Łódź, PolandCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Lodz Charles Jonscher Medical Center, ul. Milionowa 14, 93-113 Lodz: Lodz, Poland, PL Central Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Lodz Central Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Lodz Pabianice Medical Center Sp. o.o., ul. Jana Pawła II 68, 95-200 Pabianice, Poland University Clinical Hospital No.2 of Medical University of Lodz, ul. Żeromskiego 113, 90-549 Łódź, PolandCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Lodz Introduction: Bisphosphonates are pharmacological agents that inhibit bone resorption by targeting osteoclasts, thereby increasing bone density and reducing fracture risk. Although they were first synthesized in the 19th century, their clinical significance has only been recognized in the last 50 years. This study reviews the current understanding of bisphosphonates, their therapeutic advantages in various disorders, and their mechanism of action, potential interactions, and adverse effects. Aim of the study: The aim of this study is to provide an overview of the current understanding of bisphosphonates and familiarize readers with their mechanisms of action, interactions and adverse effects. It also aims to briefly introduce diseases that may be treated with bisphosphonates and how this class of medications can improve the course of each disorder. This study focuses on their therapeutic potential and associated risks, highlighting the need for further research in this area. Material and methods: Literature available in the PubMed database was reviewed using the following keywords: “bisphosphonates”; “bisphosphonates mechanism of action”; “bisphosphonates side effects”; “bisphosphonates interactions”; “bone tissue”; “skeletal system disorders”; “skeletal system”; “menopause”;” osteogenesis imperfecta”; “bone metastasis” Conclusions: The introduction of bisphosphonates represents a significant advancement in the management of conditions associated with increased bone turnover, offering clinically substantiated benefits that outweigh the associated risks. This review provides healthcare professionals with evidence-based, scientifically validated information on bisphosphonates, while also identifying critical areas for further investigation to optimize their safety and efficacy, ultimately improving patient outcomes and quality of life. https://apcz.umk.pl/JEHS/article/view/57219bisphosphonatesbisphosphonates mechanism of actionbisphosphonates side effectsbisphosphonates interactionsbone tissueskeletal system disorders |
| spellingShingle | Agnieszka Mikosińska Mateusz Litwin Jakub Parys Patrycja Kałuziak Aleksandra Witek Martyna Kaźmierczak Stanisław Jesionek Marta Jajczak Maciej Mossakowski Therapeutic potential of bisphosphonates - review of medical indications, mechanism of action, interactions and adverse effects Journal of Education, Health and Sport bisphosphonates bisphosphonates mechanism of action bisphosphonates side effects bisphosphonates interactions bone tissue skeletal system disorders |
| title | Therapeutic potential of bisphosphonates - review of medical indications, mechanism of action, interactions and adverse effects |
| title_full | Therapeutic potential of bisphosphonates - review of medical indications, mechanism of action, interactions and adverse effects |
| title_fullStr | Therapeutic potential of bisphosphonates - review of medical indications, mechanism of action, interactions and adverse effects |
| title_full_unstemmed | Therapeutic potential of bisphosphonates - review of medical indications, mechanism of action, interactions and adverse effects |
| title_short | Therapeutic potential of bisphosphonates - review of medical indications, mechanism of action, interactions and adverse effects |
| title_sort | therapeutic potential of bisphosphonates review of medical indications mechanism of action interactions and adverse effects |
| topic | bisphosphonates bisphosphonates mechanism of action bisphosphonates side effects bisphosphonates interactions bone tissue skeletal system disorders |
| url | https://apcz.umk.pl/JEHS/article/view/57219 |
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