Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases
Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological diseases. Owing to their therapeutic properties and ability to cross the blood–brain barrier, extracellular vesicles are recognized as promising drug delivery vehi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-11-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/NRR.NRR-D-24-00462 |
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| _version_ | 1841556311490166784 |
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| author | Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi Yue Peng Luo |
| author_facet | Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi Yue Peng Luo |
| author_sort | Xinyu Yang |
| collection | DOAJ |
| description | Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological diseases. Owing to their therapeutic properties and ability to cross the blood–brain barrier, extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions, including ischemic stroke, traumatic brain injury, neurodegenerative diseases, glioma, and psychosis. However, the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the body. To address these limitations, multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles, thereby enabling the delivery of therapeutic contents to specific tissues or cells. Therefore, this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles, exploring their applications in treating traumatic brain injury, ischemic stroke, Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, glioma, and psychosis. Additionally, we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological diseases. This review offers new insights for developing highly targeted therapies in this field. |
| format | Article |
| id | doaj-art-d2b2e6d8f55944f4abd8a85564874c5e |
| institution | Kabale University |
| issn | 1673-5374 1876-7958 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj-art-d2b2e6d8f55944f4abd8a85564874c5e2025-01-07T09:49:28ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53741876-79582025-11-0120113076309410.4103/NRR.NRR-D-24-00462Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseasesXinyu YangXiangyu GaoXiaofan JiangKangyi YuePeng LuoRecent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological diseases. Owing to their therapeutic properties and ability to cross the blood–brain barrier, extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions, including ischemic stroke, traumatic brain injury, neurodegenerative diseases, glioma, and psychosis. However, the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the body. To address these limitations, multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles, thereby enabling the delivery of therapeutic contents to specific tissues or cells. Therefore, this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles, exploring their applications in treating traumatic brain injury, ischemic stroke, Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, glioma, and psychosis. Additionally, we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological diseases. This review offers new insights for developing highly targeted therapies in this field.https://journals.lww.com/10.4103/NRR.NRR-D-24-00462alzheimer’s diseaseamyotrophic lateral sclerosisengineered extracellular vesiclesgliomaischemic strokeneurological diseasesparkinson’s diseasepsychosistargeted drug deliverytraumatic brain injury |
| spellingShingle | Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi Yue Peng Luo Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases Neural Regeneration Research alzheimer’s disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases parkinson’s disease psychosis targeted drug delivery traumatic brain injury |
| title | Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases |
| title_full | Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases |
| title_fullStr | Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases |
| title_full_unstemmed | Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases |
| title_short | Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases |
| title_sort | targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases |
| topic | alzheimer’s disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases parkinson’s disease psychosis targeted drug delivery traumatic brain injury |
| url | https://journals.lww.com/10.4103/NRR.NRR-D-24-00462 |
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