Transplacental and genotoxicity effects of thallium(I) during organogenesis in mice
The increased concentration of thallium (Tl) in the environment is a cause for concern because the entire population, including pregnant women, is exposed, and this metal crosses the placenta and reaches the conceptus during development. In biological models such as mice, some abnormalities and dela...
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Elsevier
2025-06-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750025000149 |
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| author | Lucila Álvarez-Barrera Rodrigo Aníbal Mateos-Nava Keyla Nahomi Hernández-Córdova Eduardo Lezama-Sánchez Víctor Alan Alcántara-Mejía Juan José Rodríguez-Mercado |
| author_facet | Lucila Álvarez-Barrera Rodrigo Aníbal Mateos-Nava Keyla Nahomi Hernández-Córdova Eduardo Lezama-Sánchez Víctor Alan Alcántara-Mejía Juan José Rodríguez-Mercado |
| author_sort | Lucila Álvarez-Barrera |
| collection | DOAJ |
| description | The increased concentration of thallium (Tl) in the environment is a cause for concern because the entire population, including pregnant women, is exposed, and this metal crosses the placenta and reaches the conceptus during development. In biological models such as mice, some abnormalities and delays in ossification occur in the fetuses of mice administered Tl on day 7 of gestation, but exposure to environmental Tl is constant during fetal development; therefore, in this study, the effects of several administrations of TI during organogenesis on the external morphology, skeletal development and genotoxicity of fetuses were evaluated. Four groups of 10 pregnant mice were administered 5.28, 6.16, 7.4 or 9.25 mg/kg body weight Tl(I) acetate intraperitoneally during fetal organogenesis. Additionally, samples were taken from fetuses from pregnant mice treated with 5.28 and 6.16 mg/kg body weight to evaluate the transplacental genotoxicity. The results revealed that the 9.25 mg/kg body weight dose produced maternal and fetal toxicity, and all of the treatment groups presented relatively high percentages of fetuses with external abnormalities, reduced bone ossification, and an increased percentage of liver cells with structural chromosomal aberrations (SCAs) and micronuclei (MNs) in blood cells. These results show that Tl(I) acetate administered during organogenesis produces abnormalities, including a delay in ossification and transplacental genotoxicity, in mouse fetuses. These findings are important because Tl has negative effects on development and may affect the health of offspring in the future because it can damage genetic material. |
| format | Article |
| id | doaj-art-d2a22058578c4ed29d798f03a23f76a9 |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | Toxicology Reports |
| spelling | doaj-art-d2a22058578c4ed29d798f03a23f76a92025-01-16T04:28:44ZengElsevierToxicology Reports2214-75002025-06-0114101896Transplacental and genotoxicity effects of thallium(I) during organogenesis in miceLucila Álvarez-Barrera0Rodrigo Aníbal Mateos-Nava1Keyla Nahomi Hernández-Córdova2Eduardo Lezama-Sánchez3Víctor Alan Alcántara-Mejía4Juan José Rodríguez-Mercado5Unidad de Investigación en Genética y Toxicología Ambiental (UNIGEN), Laboratorio 5, primer piso, Unidad Multidisciplinaria de Investigación Experimental (UMIEZ-Z). Facultad de Estudios Superiores-Zaragoza, Campus II, UNAM, Ciudad de México, Mexico; Carrera Médico Cirujano, Ciencias Biomédicas, BQ. FES-Zaragoza, UNAM, MexicoUnidad de Investigación en Genética y Toxicología Ambiental (UNIGEN), Laboratorio 5, primer piso, Unidad Multidisciplinaria de Investigación Experimental (UMIEZ-Z). Facultad de Estudios Superiores-Zaragoza, Campus II, UNAM, Ciudad de México, MexicoUnidad de Investigación en Genética y Toxicología Ambiental (UNIGEN), Laboratorio 5, primer piso, Unidad Multidisciplinaria de Investigación Experimental (UMIEZ-Z). Facultad de Estudios Superiores-Zaragoza, Campus II, UNAM, Ciudad de México, MexicoUnidad de Investigación en Genética y Toxicología Ambiental (UNIGEN), Laboratorio 5, primer piso, Unidad Multidisciplinaria de Investigación Experimental (UMIEZ-Z). Facultad de Estudios Superiores-Zaragoza, Campus II, UNAM, Ciudad de México, MexicoUnidad de Investigación en Genética y Toxicología Ambiental (UNIGEN), Laboratorio 5, primer piso, Unidad Multidisciplinaria de Investigación Experimental (UMIEZ-Z). Facultad de Estudios Superiores-Zaragoza, Campus II, UNAM, Ciudad de México, MexicoUnidad de Investigación en Genética y Toxicología Ambiental (UNIGEN), Laboratorio 5, primer piso, Unidad Multidisciplinaria de Investigación Experimental (UMIEZ-Z). Facultad de Estudios Superiores-Zaragoza, Campus II, UNAM, Ciudad de México, Mexico; Correspondence to: Facultad de Estudios Superiores-Zaragoza, Campus II, UNAM, Ciudad de México, CP 09230, Mexico.The increased concentration of thallium (Tl) in the environment is a cause for concern because the entire population, including pregnant women, is exposed, and this metal crosses the placenta and reaches the conceptus during development. In biological models such as mice, some abnormalities and delays in ossification occur in the fetuses of mice administered Tl on day 7 of gestation, but exposure to environmental Tl is constant during fetal development; therefore, in this study, the effects of several administrations of TI during organogenesis on the external morphology, skeletal development and genotoxicity of fetuses were evaluated. Four groups of 10 pregnant mice were administered 5.28, 6.16, 7.4 or 9.25 mg/kg body weight Tl(I) acetate intraperitoneally during fetal organogenesis. Additionally, samples were taken from fetuses from pregnant mice treated with 5.28 and 6.16 mg/kg body weight to evaluate the transplacental genotoxicity. The results revealed that the 9.25 mg/kg body weight dose produced maternal and fetal toxicity, and all of the treatment groups presented relatively high percentages of fetuses with external abnormalities, reduced bone ossification, and an increased percentage of liver cells with structural chromosomal aberrations (SCAs) and micronuclei (MNs) in blood cells. These results show that Tl(I) acetate administered during organogenesis produces abnormalities, including a delay in ossification and transplacental genotoxicity, in mouse fetuses. These findings are important because Tl has negative effects on development and may affect the health of offspring in the future because it can damage genetic material.http://www.sciencedirect.com/science/article/pii/S2214750025000149Abnormalities in offspringChromosomal aberrationsDelayed ossificationMaternal toxicityMicronucleusThallium(I) acetate |
| spellingShingle | Lucila Álvarez-Barrera Rodrigo Aníbal Mateos-Nava Keyla Nahomi Hernández-Córdova Eduardo Lezama-Sánchez Víctor Alan Alcántara-Mejía Juan José Rodríguez-Mercado Transplacental and genotoxicity effects of thallium(I) during organogenesis in mice Toxicology Reports Abnormalities in offspring Chromosomal aberrations Delayed ossification Maternal toxicity Micronucleus Thallium(I) acetate |
| title | Transplacental and genotoxicity effects of thallium(I) during organogenesis in mice |
| title_full | Transplacental and genotoxicity effects of thallium(I) during organogenesis in mice |
| title_fullStr | Transplacental and genotoxicity effects of thallium(I) during organogenesis in mice |
| title_full_unstemmed | Transplacental and genotoxicity effects of thallium(I) during organogenesis in mice |
| title_short | Transplacental and genotoxicity effects of thallium(I) during organogenesis in mice |
| title_sort | transplacental and genotoxicity effects of thallium i during organogenesis in mice |
| topic | Abnormalities in offspring Chromosomal aberrations Delayed ossification Maternal toxicity Micronucleus Thallium(I) acetate |
| url | http://www.sciencedirect.com/science/article/pii/S2214750025000149 |
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