Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report

Primary bladder mucinous adenocarcinoma is a rare genitourinary cancer. Here, we present the case of a 75-year-old woman where pathological and imaging findings led to the diagnosis of primary bladder mucinous adenocarcinoma. She underwent treatment with paclitaxel–ifosfamide–cisplatin (TIP). After...

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Main Authors: Shinkuro Yamamoto, Shingo Ashida, Tomoya Nao, Kaho Murakami, Ryohei Iga, Tsutomu Shimamoto, Hideo Fukuhara, Nobutaka Shimizu, Satoshi Fukata, Atsushi Kurabayashi, Takashi Karashima, Keiji Inoue
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Urology Case Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2214442024002468
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author Shinkuro Yamamoto
Shingo Ashida
Tomoya Nao
Kaho Murakami
Ryohei Iga
Tsutomu Shimamoto
Hideo Fukuhara
Nobutaka Shimizu
Satoshi Fukata
Atsushi Kurabayashi
Takashi Karashima
Keiji Inoue
author_facet Shinkuro Yamamoto
Shingo Ashida
Tomoya Nao
Kaho Murakami
Ryohei Iga
Tsutomu Shimamoto
Hideo Fukuhara
Nobutaka Shimizu
Satoshi Fukata
Atsushi Kurabayashi
Takashi Karashima
Keiji Inoue
author_sort Shinkuro Yamamoto
collection DOAJ
description Primary bladder mucinous adenocarcinoma is a rare genitourinary cancer. Here, we present the case of a 75-year-old woman where pathological and imaging findings led to the diagnosis of primary bladder mucinous adenocarcinoma. She underwent treatment with paclitaxel–ifosfamide–cisplatin (TIP). After two cycles of TIP therapy, FoundationOne CDx, a comprehensive genomic profiling test, was performed, revealing variants in ATM, SMAD4, BRD4, and NOTCH3. These genomic profiling test results may lead to the development of novel therapeutic agents for primary bladder mucinous adenocarcinoma.
format Article
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institution Kabale University
issn 2214-4420
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publishDate 2025-01-01
publisher Elsevier
record_format Article
series Urology Case Reports
spelling doaj-art-d29e084a09d54acfb9372ce266296dd92025-01-14T04:12:16ZengElsevierUrology Case Reports2214-44202025-01-0158102892Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case reportShinkuro Yamamoto0Shingo Ashida1Tomoya Nao2Kaho Murakami3Ryohei Iga4Tsutomu Shimamoto5Hideo Fukuhara6Nobutaka Shimizu7Satoshi Fukata8Atsushi Kurabayashi9Takashi Karashima10Keiji Inoue11Department of Urology, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, Japan; Corresponding author. Department of Urology, Kochi Medical School, Kohasu, Oko-cho, Nankoku, 783-8505, Japan.Department of Urology, Kochi Medical School, Nankoku, 783-8505, JapanJapanese Red Cross Kochi Hospital, Kochi, 780-8562, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, JapanPelvic Floor Center, Kochi Medical School, Nankoku, 783-8505, JapanPelvic Floor Center, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Pathology, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, JapanPrimary bladder mucinous adenocarcinoma is a rare genitourinary cancer. Here, we present the case of a 75-year-old woman where pathological and imaging findings led to the diagnosis of primary bladder mucinous adenocarcinoma. She underwent treatment with paclitaxel–ifosfamide–cisplatin (TIP). After two cycles of TIP therapy, FoundationOne CDx, a comprehensive genomic profiling test, was performed, revealing variants in ATM, SMAD4, BRD4, and NOTCH3. These genomic profiling test results may lead to the development of novel therapeutic agents for primary bladder mucinous adenocarcinoma.http://www.sciencedirect.com/science/article/pii/S2214442024002468Bladder cancerGenomic profilingMucinous adenocarcinoma
spellingShingle Shinkuro Yamamoto
Shingo Ashida
Tomoya Nao
Kaho Murakami
Ryohei Iga
Tsutomu Shimamoto
Hideo Fukuhara
Nobutaka Shimizu
Satoshi Fukata
Atsushi Kurabayashi
Takashi Karashima
Keiji Inoue
Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report
Urology Case Reports
Bladder cancer
Genomic profiling
Mucinous adenocarcinoma
title Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report
title_full Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report
title_fullStr Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report
title_full_unstemmed Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report
title_short Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report
title_sort comprehensive genomic profiling of primary bladder mucinous adenocarcinoma a rare genitourinary cancer a case report
topic Bladder cancer
Genomic profiling
Mucinous adenocarcinoma
url http://www.sciencedirect.com/science/article/pii/S2214442024002468
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