Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report
Primary bladder mucinous adenocarcinoma is a rare genitourinary cancer. Here, we present the case of a 75-year-old woman where pathological and imaging findings led to the diagnosis of primary bladder mucinous adenocarcinoma. She underwent treatment with paclitaxel–ifosfamide–cisplatin (TIP). After...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Urology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214442024002468 |
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| author | Shinkuro Yamamoto Shingo Ashida Tomoya Nao Kaho Murakami Ryohei Iga Tsutomu Shimamoto Hideo Fukuhara Nobutaka Shimizu Satoshi Fukata Atsushi Kurabayashi Takashi Karashima Keiji Inoue |
| author_facet | Shinkuro Yamamoto Shingo Ashida Tomoya Nao Kaho Murakami Ryohei Iga Tsutomu Shimamoto Hideo Fukuhara Nobutaka Shimizu Satoshi Fukata Atsushi Kurabayashi Takashi Karashima Keiji Inoue |
| author_sort | Shinkuro Yamamoto |
| collection | DOAJ |
| description | Primary bladder mucinous adenocarcinoma is a rare genitourinary cancer. Here, we present the case of a 75-year-old woman where pathological and imaging findings led to the diagnosis of primary bladder mucinous adenocarcinoma. She underwent treatment with paclitaxel–ifosfamide–cisplatin (TIP). After two cycles of TIP therapy, FoundationOne CDx, a comprehensive genomic profiling test, was performed, revealing variants in ATM, SMAD4, BRD4, and NOTCH3. These genomic profiling test results may lead to the development of novel therapeutic agents for primary bladder mucinous adenocarcinoma. |
| format | Article |
| id | doaj-art-d29e084a09d54acfb9372ce266296dd9 |
| institution | Kabale University |
| issn | 2214-4420 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Urology Case Reports |
| spelling | doaj-art-d29e084a09d54acfb9372ce266296dd92025-01-14T04:12:16ZengElsevierUrology Case Reports2214-44202025-01-0158102892Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case reportShinkuro Yamamoto0Shingo Ashida1Tomoya Nao2Kaho Murakami3Ryohei Iga4Tsutomu Shimamoto5Hideo Fukuhara6Nobutaka Shimizu7Satoshi Fukata8Atsushi Kurabayashi9Takashi Karashima10Keiji Inoue11Department of Urology, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, Japan; Corresponding author. Department of Urology, Kochi Medical School, Kohasu, Oko-cho, Nankoku, 783-8505, Japan.Department of Urology, Kochi Medical School, Nankoku, 783-8505, JapanJapanese Red Cross Kochi Hospital, Kochi, 780-8562, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, JapanPelvic Floor Center, Kochi Medical School, Nankoku, 783-8505, JapanPelvic Floor Center, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Pathology, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, JapanDepartment of Urology, Kochi Medical School, Nankoku, 783-8505, JapanPrimary bladder mucinous adenocarcinoma is a rare genitourinary cancer. Here, we present the case of a 75-year-old woman where pathological and imaging findings led to the diagnosis of primary bladder mucinous adenocarcinoma. She underwent treatment with paclitaxel–ifosfamide–cisplatin (TIP). After two cycles of TIP therapy, FoundationOne CDx, a comprehensive genomic profiling test, was performed, revealing variants in ATM, SMAD4, BRD4, and NOTCH3. These genomic profiling test results may lead to the development of novel therapeutic agents for primary bladder mucinous adenocarcinoma.http://www.sciencedirect.com/science/article/pii/S2214442024002468Bladder cancerGenomic profilingMucinous adenocarcinoma |
| spellingShingle | Shinkuro Yamamoto Shingo Ashida Tomoya Nao Kaho Murakami Ryohei Iga Tsutomu Shimamoto Hideo Fukuhara Nobutaka Shimizu Satoshi Fukata Atsushi Kurabayashi Takashi Karashima Keiji Inoue Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report Urology Case Reports Bladder cancer Genomic profiling Mucinous adenocarcinoma |
| title | Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report |
| title_full | Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report |
| title_fullStr | Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report |
| title_full_unstemmed | Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report |
| title_short | Comprehensive genomic profiling of primary bladder mucinous adenocarcinoma, a rare genitourinary cancer: A case report |
| title_sort | comprehensive genomic profiling of primary bladder mucinous adenocarcinoma a rare genitourinary cancer a case report |
| topic | Bladder cancer Genomic profiling Mucinous adenocarcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2214442024002468 |
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