Characterization of cancer-driving nucleotides (CDNs) across genes, cancer types, and patients

Characterization of cancer-driving nucleotides (CDNs) across genes, cancer types, and patients

A central goal of cancer genomics is to identify, in each patient, all the cancer-driving mutations. Among them, point mutations are referred to as cancer-driving nucleotides (CDNs), which recur in cancers. The companion study shows that the probability of i recurrent hits in n patients would decrea...

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Bibliographic Details
Main Authors: Lingjie Zhang, Tong Deng, Zhongqi Liufu, Xiangnyu Chen, Shijie Wu, Xueyu Liu, Changhao Shi, Bingjie Chen, Zheng Hu, Qichun Cai, Chenli Liu, Mengfeng Li, Miles E Tracy, Xuemei Lu, Chung-I Wu, Hai-Jun Wen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
cancer evolution
cancer drivers
targeted therapy
Online Access:https://elifesciences.org/articles/99341
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