Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns
AIM: To explore the morphological and functional parameters to evaluate the effectiveness of intravitreal injections of ranibizumab (IVR) in treating macular edema (ME) secondary to retinal vein occlusion (RVO). METHODS: This retrospective study involved 65 RVO patients (65 eyes) who received IVR an...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2025-02-01
|
| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2025/2/20250211.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841526983798816768 |
|---|---|
| author | Yue Xu Yue-Cong Yin Ze-Yu Song Xiao-Yu Zhou Jia-Ju Zhang Juan Liang |
| author_facet | Yue Xu Yue-Cong Yin Ze-Yu Song Xiao-Yu Zhou Jia-Ju Zhang Juan Liang |
| author_sort | Yue Xu |
| collection | DOAJ |
| description | AIM: To explore the morphological and functional parameters to evaluate the effectiveness of intravitreal injections of ranibizumab (IVR) in treating macular edema (ME) secondary to retinal vein occlusion (RVO). METHODS: This retrospective study involved 65 RVO patients (65 eyes) who received IVR and were followed-up for more than 3mo. ME was categorized into cystoid macular edema (CME), diffuse retinal thickening (DRT), and serous retinal detachment (SRD) according to optical coherence tomography (OCT) images. The comparison of best corrected visual acuity (BCVA; logMAR) and central macular thickness (CMT) among different follow-up points and those among 3 groups were performed by Kruskal-Wallis test. The correlation between BCVA and baseline parameters during treatment was analyzed using Spearman correlation analysis. RESULTS: BCVA tended to improve in all groups, with marked improvement in CME and DRT groups. CMT showed the greatest reduction after 1wk, and remained stable over the following 3mo. DRT patients had the worst BCVA and the highest CMT at baseline, but the differences became smaller after IVR treatment. CMT in SRD group was significantly better than in CME and DRT groups 3mo after IVR. Most patients of CME and SRD groups transitioned to a normal pattern at 3mo follow-up. DRT patients were most likely to transform into the other morphological groups, while SRD patients showed minimal transitions. BCVA at baseline was identified as the most important prognostic indicator in all 3 groups. Additionally, DRT patients with a longer clinical course, higher CMT and central retinal vein occlusion (CRVO) tend to exhibit worse BCVA after treatment. In addition, CRVO patients are more likely to have worse BCVA at 2 and 3mo follow-up compared with branch retinal vein occlusion (BRVO) patients in CME group. SRD patients with higher baseline CMT were prone to experiencing worse BCVA after treatment. CONCLUSION: The effectiveness of IVR is strongly correlated with baseline BCVA in all 3 groups. Baseline parameters including clinical course, CMT, and RVO position are also useful in predicting the BCVA at different time points after treatment. |
| format | Article |
| id | doaj-art-d274de0ef61241a2903a3f219b6146fd |
| institution | Kabale University |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-d274de0ef61241a2903a3f219b6146fd2025-01-16T07:54:35ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-02-0118227528210.18240/ijo.2025.02.1120250211Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patternsYue Xu0Yue-Cong Yin1Ze-Yu Song2Xiao-Yu Zhou3Jia-Ju Zhang4Juan Liang5Juan Liang. Department of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, No.9 Chongwen Road, Suzhou 215000, Jiangsu Province, China. 1374439153@qq.comDepartment of Ophthalmology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, ChinaDepartment of Ophthalmology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, ChinaDepartment of Ophthalmology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, ChinaDepartment of Ophthalmology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, ChinaDepartment of Ophthalmology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, ChinaAIM: To explore the morphological and functional parameters to evaluate the effectiveness of intravitreal injections of ranibizumab (IVR) in treating macular edema (ME) secondary to retinal vein occlusion (RVO). METHODS: This retrospective study involved 65 RVO patients (65 eyes) who received IVR and were followed-up for more than 3mo. ME was categorized into cystoid macular edema (CME), diffuse retinal thickening (DRT), and serous retinal detachment (SRD) according to optical coherence tomography (OCT) images. The comparison of best corrected visual acuity (BCVA; logMAR) and central macular thickness (CMT) among different follow-up points and those among 3 groups were performed by Kruskal-Wallis test. The correlation between BCVA and baseline parameters during treatment was analyzed using Spearman correlation analysis. RESULTS: BCVA tended to improve in all groups, with marked improvement in CME and DRT groups. CMT showed the greatest reduction after 1wk, and remained stable over the following 3mo. DRT patients had the worst BCVA and the highest CMT at baseline, but the differences became smaller after IVR treatment. CMT in SRD group was significantly better than in CME and DRT groups 3mo after IVR. Most patients of CME and SRD groups transitioned to a normal pattern at 3mo follow-up. DRT patients were most likely to transform into the other morphological groups, while SRD patients showed minimal transitions. BCVA at baseline was identified as the most important prognostic indicator in all 3 groups. Additionally, DRT patients with a longer clinical course, higher CMT and central retinal vein occlusion (CRVO) tend to exhibit worse BCVA after treatment. In addition, CRVO patients are more likely to have worse BCVA at 2 and 3mo follow-up compared with branch retinal vein occlusion (BRVO) patients in CME group. SRD patients with higher baseline CMT were prone to experiencing worse BCVA after treatment. CONCLUSION: The effectiveness of IVR is strongly correlated with baseline BCVA in all 3 groups. Baseline parameters including clinical course, CMT, and RVO position are also useful in predicting the BCVA at different time points after treatment.http://ies.ijo.cn/en_publish/2025/2/20250211.pdfretinal vein occlusionoptical coherence tomographyserous retinal detachmentcystoid macular edemadiffuse retinal thickening |
| spellingShingle | Yue Xu Yue-Cong Yin Ze-Yu Song Xiao-Yu Zhou Jia-Ju Zhang Juan Liang Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns International Journal of Ophthalmology retinal vein occlusion optical coherence tomography serous retinal detachment cystoid macular edema diffuse retinal thickening |
| title | Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns |
| title_full | Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns |
| title_fullStr | Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns |
| title_full_unstemmed | Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns |
| title_short | Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns |
| title_sort | comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns |
| topic | retinal vein occlusion optical coherence tomography serous retinal detachment cystoid macular edema diffuse retinal thickening |
| url | http://ies.ijo.cn/en_publish/2025/2/20250211.pdf |
| work_keys_str_mv | AT yuexu comparisonoftheeffectofranibizumabinretinalveinocclusionandmacularedemawithdifferentopticalcoherencetomographicpatterns AT yuecongyin comparisonoftheeffectofranibizumabinretinalveinocclusionandmacularedemawithdifferentopticalcoherencetomographicpatterns AT zeyusong comparisonoftheeffectofranibizumabinretinalveinocclusionandmacularedemawithdifferentopticalcoherencetomographicpatterns AT xiaoyuzhou comparisonoftheeffectofranibizumabinretinalveinocclusionandmacularedemawithdifferentopticalcoherencetomographicpatterns AT jiajuzhang comparisonoftheeffectofranibizumabinretinalveinocclusionandmacularedemawithdifferentopticalcoherencetomographicpatterns AT juanliang comparisonoftheeffectofranibizumabinretinalveinocclusionandmacularedemawithdifferentopticalcoherencetomographicpatterns |