Mesenchymal Stem Cell–derived Extracellular Vesicles: An Emerging Therapeutic Strategy for Diabetic Wound Healing
One of the most serious side effects of diabetes is diabetic foot ulceration (DFU). It is a severe and extremely morbid illness that has been linked to higher mortality on its own. The development of effective wound therapeutics in the future may be influenced by our current and developing understan...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Secretariat of The Indonesian Biomedical Journal
2024-12-01
|
| Series: | Indonesian Biomedical Journal |
| Online Access: | https://inabj.org/index.php/ibj/article/view/3407 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841558872365465600 |
|---|---|
| author | Anna Meiliana Nurrani Mustika Dewi Andi Wijaya |
| author_facet | Anna Meiliana Nurrani Mustika Dewi Andi Wijaya |
| author_sort | Anna Meiliana |
| collection | DOAJ |
| description | One of the most serious side effects of diabetes is diabetic foot ulceration (DFU). It is a severe and extremely morbid illness that has been linked to higher mortality on its own. The development of effective wound therapeutics in the future may be influenced by our current and developing understanding of wound pathophysiology. By reestablishing cellular functioning, small extracellular vesicles (sEVs), a crucial medium for intercellular communications, exhibit encouraging therapeutic potential in the treatment of DFU. Mesenchymal stem cell (MSC) derived exosomes and engineered extracellular vesicles (EVs) have the potential to aid in the healing of wounds. Along with encouraging the growth and stimulation of endothelial cells, keratinocytes, and fibroblasts, they also have immunomodulatory and anti-inflammatory properties. They help prevent damaged cells from dying, revitalize senescent cells, and boost angiogenesis. MSC-EVs can be a safe, effective and ethical therapy for DFU by increasing M2 macrophages polarization, improving the proliferation, reducing scar, and improving angiogenesis.
KEYWORDS: mesenchymal stem cell, extracellular vesicle, diabetic wound, wound healing |
| format | Article |
| id | doaj-art-d2523b74351345d4aff3eda634a60c9c |
| institution | Kabale University |
| issn | 2085-3297 2355-9179 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj-art-d2523b74351345d4aff3eda634a60c9c2025-01-06T02:04:18ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792024-12-0116648750910.18585/inabj.v16i6.3407603Mesenchymal Stem Cell–derived Extracellular Vesicles: An Emerging Therapeutic Strategy for Diabetic Wound HealingAnna Meiliana0Nurrani Mustika Dewi1Andi Wijaya2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjajaran, Jl. Raya Bandung, Sumedang Km. 21, Jatinangor 45363Prodia Education and Research Institute, Jl. Kramat Raya No. 150, Jakarta, 10430Prodia Clinical Laboratory, Jl. Supratman No 43, Bandung 40114One of the most serious side effects of diabetes is diabetic foot ulceration (DFU). It is a severe and extremely morbid illness that has been linked to higher mortality on its own. The development of effective wound therapeutics in the future may be influenced by our current and developing understanding of wound pathophysiology. By reestablishing cellular functioning, small extracellular vesicles (sEVs), a crucial medium for intercellular communications, exhibit encouraging therapeutic potential in the treatment of DFU. Mesenchymal stem cell (MSC) derived exosomes and engineered extracellular vesicles (EVs) have the potential to aid in the healing of wounds. Along with encouraging the growth and stimulation of endothelial cells, keratinocytes, and fibroblasts, they also have immunomodulatory and anti-inflammatory properties. They help prevent damaged cells from dying, revitalize senescent cells, and boost angiogenesis. MSC-EVs can be a safe, effective and ethical therapy for DFU by increasing M2 macrophages polarization, improving the proliferation, reducing scar, and improving angiogenesis. KEYWORDS: mesenchymal stem cell, extracellular vesicle, diabetic wound, wound healinghttps://inabj.org/index.php/ibj/article/view/3407 |
| spellingShingle | Anna Meiliana Nurrani Mustika Dewi Andi Wijaya Mesenchymal Stem Cell–derived Extracellular Vesicles: An Emerging Therapeutic Strategy for Diabetic Wound Healing Indonesian Biomedical Journal |
| title | Mesenchymal Stem Cell–derived Extracellular Vesicles: An Emerging Therapeutic Strategy for Diabetic Wound Healing |
| title_full | Mesenchymal Stem Cell–derived Extracellular Vesicles: An Emerging Therapeutic Strategy for Diabetic Wound Healing |
| title_fullStr | Mesenchymal Stem Cell–derived Extracellular Vesicles: An Emerging Therapeutic Strategy for Diabetic Wound Healing |
| title_full_unstemmed | Mesenchymal Stem Cell–derived Extracellular Vesicles: An Emerging Therapeutic Strategy for Diabetic Wound Healing |
| title_short | Mesenchymal Stem Cell–derived Extracellular Vesicles: An Emerging Therapeutic Strategy for Diabetic Wound Healing |
| title_sort | mesenchymal stem cell derived extracellular vesicles an emerging therapeutic strategy for diabetic wound healing |
| url | https://inabj.org/index.php/ibj/article/view/3407 |
| work_keys_str_mv | AT annameiliana mesenchymalstemcellderivedextracellularvesiclesanemergingtherapeuticstrategyfordiabeticwoundhealing AT nurranimustikadewi mesenchymalstemcellderivedextracellularvesiclesanemergingtherapeuticstrategyfordiabeticwoundhealing AT andiwijaya mesenchymalstemcellderivedextracellularvesiclesanemergingtherapeuticstrategyfordiabeticwoundhealing |