KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activation

KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activation

Abstract KANK1 is expressed in epithelial cells and connects focal adhesions with the adjacent cortical microtubule stabilizing complex. Although KANK1 was shown to suppress cancer cell growth in vitro, TCGA database points to high KANK1 levels associated with poor prognosis in a wide spectrum of hu...

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Bibliographic Details
Main Authors: Shiny Shengzhen Guo, Zhiying Liu, Guan M. Wang, Zhiqi Sun, Kaikai Yu, James P. Fawcett, Reinhard Buettner, Bo Gao, Reinhard Fässler
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54645-9
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