The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding

The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding

Abstract: The G haplotype is a group of co-inherited single nucleotide variants in the F5 gene that reduce venous thromboembolism (VTE) risk. Although 7% of the population is homozygous for the G haplotype (F5-G/G), the underlying mechanism of VTE protection is poorly understood. Using RNA sequencin...

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Main Authors: Matthew C. Sims, Magdalena Gierula, Jonathan C. Stephens, Alex Tokolyi, Luca Stefanucci, Elodie Persyn, Luanluan Sun, Janine H. Collins, Emma E. Davenport, Emanuele Di Angelantonio, Kate Downes, Michael Inouye, Dirk S. Paul, Will Thomas, Alexander Tolios, Willem H. Ouwehand, Nicholas S. Gleadall, James T. B. Crawley, Adam S. Butterworth, Mattia Frontini, Josefin Ahnström
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952924005809
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http://www.sciencedirect.com/science/article/pii/S2473952924005809

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