Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α

Hypoxia drives the formation of lung micropapillary adenocarcinoma-like structure through hypoxia-inducible factor-1α

Abstract Micropapillary adenocarcinoma (MPC) is an aggressive histological subtype of lung adenocarcinoma (LUAD). MPC is composed of small clusters of cancer cells exhibiting inverted polarity. However, the mechanism underlying its formation is poorly understood. Here we show that hypoxia is involve...

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Bibliographic Details
Main Authors: Daisuke Umeda, Akikazu Harada, Daisuke Motooka, Shinichiro Tahara, Masako Kurashige, Kansuke Kido, Tsuyoshi Takashima, Hiroki Kiyokawa, Koto Ukon, Takahiro Matsui, Shinji Matsumoto, Yasushi Shintani, Daisuke Okuzaki, Akira Kikuchi, Satoshi Nojima, Eiichi Morii
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Lung micropapillary adenocarcinoma
Hypoxia
Matrigel
Three-dimensional cell culture
Hypoxia-inducible factor-1α
MUC1
Online Access:https://doi.org/10.1038/s41598-024-80280-x
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