Bactericidal activity of mammalian histones is caused by large membrane pore formation

Bactericidal activity of mammalian histones is caused by large membrane pore formation

Summary: Histones have an important role in eukaryotic innate immunity, wherein histones co-localize with antimicrobial peptides (AMPs). The mechanism of histone cooperation with AMPs and the extent to which histones form pores both remain a mystery. Here, we show that histones form large pores in b...

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Bibliographic Details
Main Authors: Leora Duong, Yonghan Wu, Summer J. Kasallis, Serena Abbondante, Paul J. Hurst, Michaela E. Marshall, Katherine McCarthy, Babu J.N. Reddy, Jean-Louis Bru, Kumar Perinbam, Eric Pearlman, Joseph P. Patterson, Steven P. Gross, Albert Siryaporn
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004292
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