Determinants of Survival in Cancer Rectum: Our Experience at a Tertiary Care Center
Introduction: As per GLOBOCON 2018, colorectal cancer is the seventh leading cancer in India. Our primary aim was to look for various clinical, radiological, and pathological factors in the cancer rectum and their impact on overall survival (OS) and disease-free survival (DFS) at our tertiary care c...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Acta Medica International |
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| Online Access: | https://journals.lww.com/10.4103/amit.amit_26_22 |
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| author | Rashmi Singh Anup Kumar Manika Verma Payal Raina |
| author_facet | Rashmi Singh Anup Kumar Manika Verma Payal Raina |
| author_sort | Rashmi Singh |
| collection | DOAJ |
| description | Introduction:
As per GLOBOCON 2018, colorectal cancer is the seventh leading cancer in India. Our primary aim was to look for various clinical, radiological, and pathological factors in the cancer rectum and their impact on overall survival (OS) and disease-free survival (DFS) at our tertiary care center.
Materials and Methods:
Nineteen patients’ clinical and treatment details were compiled from the physical records stored in the department. Calculation of median survival (MS), mean OS, and DFS was done using the Kaplan–Meier method, and the Log-rank test was applied.
Results:
Bleeding per rectum (84.2%), increased serum carcinoembryonic antigen (63.2%), Grade 2 adenocarcinoma (95%), ulceroinfiltrating type (57.89%), and tumor length >5 cm (73.68%), and stage III (57.89%) were most common observation. Fifteen patients underwent upfront surgery, among them 66.6% of cases had ≤12 lymph node removal. 40% (6 / 15) of patients had either proximal (n = 1), distal (n = 2), or CRM positive (n = 3) (3 / 6). The MS was 45 months, and increased mean OS, as well as DFS, was observed in patients having younger age, female sex, stage II, N0, ulcer-infiltrating tumor, tumor length <5 cm, negative margin, abdominoperineal resection, LN resected <12 but P value were nonsignificant.
Conclusions:
We observed that increased nodal burden, margin positivity, and advanced T in histopathology are associated with locoregional and distant failure. |
| format | Article |
| id | doaj-art-d1e20dc3b30a4afe8bb822b4efaf842e |
| institution | Kabale University |
| issn | 2349-0578 2349-0896 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Acta Medica International |
| spelling | doaj-art-d1e20dc3b30a4afe8bb822b4efaf842e2025-01-06T14:27:37ZengWolters Kluwer Medknow PublicationsActa Medica International2349-05782349-08962024-12-0111321321810.4103/amit.amit_26_22Determinants of Survival in Cancer Rectum: Our Experience at a Tertiary Care CenterRashmi SinghAnup KumarManika VermaPayal RainaIntroduction: As per GLOBOCON 2018, colorectal cancer is the seventh leading cancer in India. Our primary aim was to look for various clinical, radiological, and pathological factors in the cancer rectum and their impact on overall survival (OS) and disease-free survival (DFS) at our tertiary care center. Materials and Methods: Nineteen patients’ clinical and treatment details were compiled from the physical records stored in the department. Calculation of median survival (MS), mean OS, and DFS was done using the Kaplan–Meier method, and the Log-rank test was applied. Results: Bleeding per rectum (84.2%), increased serum carcinoembryonic antigen (63.2%), Grade 2 adenocarcinoma (95%), ulceroinfiltrating type (57.89%), and tumor length >5 cm (73.68%), and stage III (57.89%) were most common observation. Fifteen patients underwent upfront surgery, among them 66.6% of cases had ≤12 lymph node removal. 40% (6 / 15) of patients had either proximal (n = 1), distal (n = 2), or CRM positive (n = 3) (3 / 6). The MS was 45 months, and increased mean OS, as well as DFS, was observed in patients having younger age, female sex, stage II, N0, ulcer-infiltrating tumor, tumor length <5 cm, negative margin, abdominoperineal resection, LN resected <12 but P value were nonsignificant. Conclusions: We observed that increased nodal burden, margin positivity, and advanced T in histopathology are associated with locoregional and distant failure.https://journals.lww.com/10.4103/amit.amit_26_22ca rectumdisease-free survivaloverall survivalprognosisprognostic factors |
| spellingShingle | Rashmi Singh Anup Kumar Manika Verma Payal Raina Determinants of Survival in Cancer Rectum: Our Experience at a Tertiary Care Center Acta Medica International ca rectum disease-free survival overall survival prognosis prognostic factors |
| title | Determinants of Survival in Cancer Rectum: Our Experience at a Tertiary Care Center |
| title_full | Determinants of Survival in Cancer Rectum: Our Experience at a Tertiary Care Center |
| title_fullStr | Determinants of Survival in Cancer Rectum: Our Experience at a Tertiary Care Center |
| title_full_unstemmed | Determinants of Survival in Cancer Rectum: Our Experience at a Tertiary Care Center |
| title_short | Determinants of Survival in Cancer Rectum: Our Experience at a Tertiary Care Center |
| title_sort | determinants of survival in cancer rectum our experience at a tertiary care center |
| topic | ca rectum disease-free survival overall survival prognosis prognostic factors |
| url | https://journals.lww.com/10.4103/amit.amit_26_22 |
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