FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems
Summary: The FOXP2/Foxp2 gene, linked to fine motor control in vertebrates, is a potential candidate gene thought to play a prominent role in human language production. It is expressed specifically in a subset of corticothalamic (CT) pyramidal cells (PCs) in layer 6 (L6) of the neocortex. These L6 F...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224028736 |
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| author | Guanxiao Qi Danqing Yang Fernando Messore Arco Bast Felipe Yáñez Marcel Oberlaender Dirk Feldmeyer |
| author_facet | Guanxiao Qi Danqing Yang Fernando Messore Arco Bast Felipe Yáñez Marcel Oberlaender Dirk Feldmeyer |
| author_sort | Guanxiao Qi |
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| description | Summary: The FOXP2/Foxp2 gene, linked to fine motor control in vertebrates, is a potential candidate gene thought to play a prominent role in human language production. It is expressed specifically in a subset of corticothalamic (CT) pyramidal cells (PCs) in layer 6 (L6) of the neocortex. These L6 FOXP2+ PCs project exclusively to the thalamus, with L6a PCs targeting first-order or both first- and higher-order thalamic nuclei, whereas L6b PCs connect only to higher-order nuclei. Synaptic connections established by both L6a and L6b FOXP2+ PCs have low release probabilities and respond strongly to acetylcholine (ACh), triggering action potential (AP) trains. Notably, L6b FOXP2− PCs are more sensitive to ACh than L6a, and L6b FOXP2+ PCs also react robustly to dopamine. Thus, FOXP2 labels L6a and L6b CT PCs, which are precisely regulated by neuromodulators, highlighting their roles as potent modulators of thalamic activity. |
| format | Article |
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| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | iScience |
| spelling | doaj-art-d1d82dca3d4a4aacb5a580a47d71be012025-01-05T04:28:32ZengElsevieriScience2589-00422025-01-01281111646FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systemsGuanxiao Qi0Danqing Yang1Fernando Messore2Arco Bast3Felipe Yáñez4Marcel Oberlaender5Dirk Feldmeyer6Institute of Neuroscience and Medicine 10, Research Centre Jülich, 52425 Jülich, GermanyInstitute of Neuroscience and Medicine 10, Research Centre Jülich, 52425 Jülich, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH University Hospital, 52074 Aachen, GermanyIn Silico Brain Sciences Group, Max Planck Institute for Neurobiology of Behaviour – Caesar, 53175 Bonn, Germany; International Max Planck Research School (IMPRS) for Brain and Behavior, 53175 Bonn, GermanyIn Silico Brain Sciences Group, Max Planck Institute for Neurobiology of Behaviour – Caesar, 53175 Bonn, Germany; International Max Planck Research School (IMPRS) for Brain and Behavior, 53175 Bonn, GermanyIn Silico Brain Sciences Group, Max Planck Institute for Neurobiology of Behaviour – Caesar, 53175 Bonn, Germany; International Max Planck Research School (IMPRS) for Intelligent Systems, 72076 Tübingen, GermanyIn Silico Brain Sciences Group, Max Planck Institute for Neurobiology of Behaviour – Caesar, 53175 Bonn, Germany; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 Amsterdam, the NetherlandsInstitute of Neuroscience and Medicine 10, Research Centre Jülich, 52425 Jülich, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH University Hospital, 52074 Aachen, Germany; Jülich-Aachen-Research Alliance ‘Brain’ - Translational Brain Medicine, Aachen, Germany; Corresponding authorSummary: The FOXP2/Foxp2 gene, linked to fine motor control in vertebrates, is a potential candidate gene thought to play a prominent role in human language production. It is expressed specifically in a subset of corticothalamic (CT) pyramidal cells (PCs) in layer 6 (L6) of the neocortex. These L6 FOXP2+ PCs project exclusively to the thalamus, with L6a PCs targeting first-order or both first- and higher-order thalamic nuclei, whereas L6b PCs connect only to higher-order nuclei. Synaptic connections established by both L6a and L6b FOXP2+ PCs have low release probabilities and respond strongly to acetylcholine (ACh), triggering action potential (AP) trains. Notably, L6b FOXP2− PCs are more sensitive to ACh than L6a, and L6b FOXP2+ PCs also react robustly to dopamine. Thus, FOXP2 labels L6a and L6b CT PCs, which are precisely regulated by neuromodulators, highlighting their roles as potent modulators of thalamic activity.http://www.sciencedirect.com/science/article/pii/S2589004224028736Molecular biologyNeuroscience |
| spellingShingle | Guanxiao Qi Danqing Yang Fernando Messore Arco Bast Felipe Yáñez Marcel Oberlaender Dirk Feldmeyer FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems iScience Molecular biology Neuroscience |
| title | FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems |
| title_full | FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems |
| title_fullStr | FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems |
| title_full_unstemmed | FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems |
| title_short | FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems |
| title_sort | foxp2 immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems |
| topic | Molecular biology Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224028736 |
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