Therapeutic effect and mechanism of gigantol on hyperuricemia

Therapeutic effect and mechanism of gigantol on hyperuricemia

This study aimed to evaluate the therapeutic effects of gigantol on hyperuricemia (HUA) and investigate the underlying mechanism of HUA. A mouse model of HUA was made by gavage of potassium oxonate, and HK-2 and AML12 cell models were made by adenosine and xanthine oxidase (XOD) induction. We tested...

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Main Authors: Yuanfan Wu, Xia Sun, Yuhan Jia, Tianshu Gao, Jin Xu, Youqiao Qian, Naiqi Pei, Lilin Wang, Qiaohong Zheng, Honglei Li, Zhen Chen, Yijiao Liu, Yang Ma, Hui Chen, Yuanyuan Ye, Jiaxin Zhao, Yi Zhou, Xiaoqing Chen, Baosheng Huang, Yefeng Liu, Yin Zhu, Ning Xue, Juan Zhang, Guangfeng Ji, Xing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Endocrinology
Subjects:
gigantol
HUA
xanthine oxidase inhibitor
UA transporters
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1474808/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1474808/full

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